アンドロゲン結合タンパク質
同義/類義語：性ホルモン結合グルプリン
英訳・(英)同義/類義語：androgen-binding protein, sex hormone-binding globulin
ステロイド性ホルモンと結合する血液タンパク質で、性ホルモンの運搬などにはたらく。
英訳・(英)同義/類義語：androgen-binding protein, sex hormone-binding globulin
ステロイド性ホルモンと結合する血液タンパク質で、性ホルモンの運搬などにはたらく。
「生物学用語辞典」の他の用語
| 酵素タンパク質モチーフなど： | アンチトロンビンIII アンドロゲン アンドロゲン受容体 アンドロゲン結合タンパク質 イオンゲート イオンチャネル イオンチャネル内蔵型受容体 |
性ホルモン結合グロブリン
(sex hormone binding globulin から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/06/08 14:32 UTC 版)
性ホルモン結合グロブリン（Sex hormone-binding globulin, SHBG）または性ステロイド結合グロブリン（Sex steroid-binding globulin, SSBG）は、アンドロゲンとエストロゲンに結合する糖タンパク質である。プロゲステロン、コルチゾール、その他の副腎皮質ホルモン等の他のステロイドホルモンはトランスコルチン（CBG）に結合する。SHBGは、鳥類を除くすべての脊椎動物に存在する[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000129214 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005202 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d e f g h i j k l “Diverse roles for sex hormone-binding globulin in reproduction”. Biology of Reproduction 85 (3): 431–41. (September 2011). doi:10.1095/biolreprod.111.092593. PMC 4480437. PMID 21613632.
- ^ a b “Testosterone effects on the breast: implications for testosterone therapy for women”. Endocrine Reviews 25 (3): 374–88. (June 2004). doi:10.1210/er.2003-0016. PMID 15180949.
- ^ a b c d e f g h i Hammond, Geoffrey L. (25 April 2017). “Sex Hormone-Binding Globulin and the Metabolic Syndrome”. In Winters, Stephen J.; Huhtaniemi, Ilpo T.. Male Hypogonadism: Basic, Clinical and Therapeutic Principles. Humana Press. pp. 305–324. doi:10.1007/978-3-319-53298-1_15. ISBN 978-3-319-53298-1
- ^ Becker, K.L.; Bilezikian, John P.; Bremner, William J.; Hung, Wellington; Kahn, C. Ronald (24 April 2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. ISBN 978-0-7817-1750-2 2012年8月4日閲覧。
- ^ The Menopause. Springer Science & Business Media. (6 December 2012). pp. 62–. ISBN 978-1-4612-5525-3
- ^ Fritz, Marc A.; Speroff, Leon (28 March 2012). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 44–. ISBN 978-1-4511-4847-3
- ^ “Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction”. J. Clin. Invest. 109 (7): 973–81. (April 2002). doi:10.1172/JCI14060. PMC 150924. PMID 11927624.
- ^ a b c “Sex hormone-binding globulin: gene organization and structure/function analyses”. Hormone Research 45 (3–5): 197–201. (1996). doi:10.1159/000184787. PMID 8964583.
- ^ * “Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12----p13)”. Cytogenetics and Cell Genetics 54 (1–2): 65–7. (1991). doi:10.1159/000132958. PMID 2249477.
- ^ “The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap”. Steroids 63 (1): 2–4. (January 1998). doi:10.1016/S0039-128X(97)00087-1. PMID 9437788.
- ^ “Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing”. BMC Molecular Biology 10 (1): 37. (May 2009). doi:10.1186/1471-2199-10-37. PMC 2694190. PMID 19416531.
- ^ “Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence”. Molecular Biology Reports 37 (1): 235–9. (January 2010). doi:10.1007/s11033-009-9639-7. PMID 19649728.
- ^ “Single-nucleotide polymorphism, rs1799941 in the Sex Hormone-Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study”. Andrology 2 (2): 212–8. (March 2014). doi:10.1111/j.2047-2927.2013.00174.x. PMID 24327369.
- ^ “Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women”. Cancer Epidemiology, Biomarkers & Prevention 17 (12): 3490–8. (December 2008). doi:10.1158/1055-9965.EPI-08-0734. PMC 2660245. PMID 19064566.
- ^ a b “The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain”. FEBS Letters 215 (1): 100–4. (May 1987). doi:10.1016/0014-5793(87)80121-7. PMID 3569533.
- ^ “Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha”. Journal of Molecular Endocrinology 43 (1): 19–27. (July 2009). doi:10.1677/JME-09-0025. PMID 19336534.
- ^ “Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene”. The Journal of Clinical Investigation 117 (12): 3979–87. (December 2007). doi:10.1172/JCI32249. PMC 2066187. PMID 17992261.
- ^ “IL1β down-regulation of sex hormone-binding globulin production by decreasing HNF-4α via MEK-1/2 and JNK MAPK pathways”. Molecular Endocrinology 26 (11): 1917–27. (November 2012). doi:10.1210/me.2012-1152. PMC 5416961. PMID 22902540.
- ^ “Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin”. Diabetes 61 (2): 372–82. (February 2012). doi:10.2337/db11-0727. PMC 3266423. PMID 22210320.
- ^ “Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study”. Cardiovascular Diabetology 11: 130. (October 2012). doi:10.1186/1475-2840-11-130. PMC 3537568. PMID 23066943.
- ^ Unit Code 91215 Archived 2011-07-20 at the Wayback Machine. at Mayo Clinic Medical Laboratories. Retrieved April 2011
- ^ [1]“10 Simple Ways To Lower SHBG (#9 Is Fake News!)” (2019年7月27日). 2021年10月4日閲覧。
- ^ “Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy”. Clin. Endocrinol. (Oxf) 40 (2): 263–7. (February 1994). doi:10.1111/j.1365-2265.1994.tb02478.x. PMID 8137527.
- ^ a b c d O'Leary P, Boyne P, Flett P, Beilby J, James I (1991). “Longitudinal assessment of changes in reproductive hormones during normal pregnancy”. Clin Chem 37 (5): 667–72. doi:10.1093/clinchem/37.5.667. PMID 1827758.
- ^ “Study on the binding of dihydrotestosterone, testosterone and oestradiol with sex hormone binding globulin”. Clin. Chim. Acta 80 (1): 171–80. (October 1977). doi:10.1016/0009-8981(77)90276-5. PMID 561671.
- ^ “Response of serum testosterone and its precursor steroids, SHBG and CBG to anabolic steroid and testosterone self-administration in man”. Journal of Steroid Biochemistry 23 (1): 33–8. (July 1985). doi:10.1016/0022-4731(85)90257-2. PMID 3160892.
- ^ “Sex hormone-binding globulin and risk of type 2 diabetes in women and men”. The New England Journal of Medicine 361 (12): 1152–63. (September 2009). doi:10.1056/NEJMoa0804381. PMC 2774225. PMID 19657112.
- ^ “Long-term effects of calorie restriction on serum sex-hormone concentrations in men”. Aging Cell 9 (2): 236–42. (April 2010). doi:10.1111/j.1474-9726.2010.00553.x. PMC 3569090. PMID 20096034.
- ^ “Bioavailability of albumin-bound testosterone”. The Journal of Clinical Endocrinology and Metabolism 61 (4): 705–10. (October 1985). doi:10.1210/jcem-61-4-705. PMID 4040924.
- ^ “Sex hormone-binding globulin and type 2 diabetes mellitus”. Trends in Endocrinology and Metabolism 23 (1): 32–40. (January 2012). doi:10.1016/j.tem.2011.09.005. PMC 3351377. PMID 22047952.
- ^ “Interactions of sex hormone-binding globulin with target cells”. Molecular and Cellular Endocrinology 316 (1): 79–85. (March 2010). doi:10.1016/j.mce.2009.08.009. PMID 19698759.
- ^ a b IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; World Health Organization; International Agency for Research on Cancer (2007). Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. p. 157. ISBN 978-92-832-1291-1
- ^ a b “Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma”. J. Clin. Endocrinol. Metab. 53 (1): 69–75. (July 1981). doi:10.1210/jcem-53-1-69. PMID 7195405.
- ^ “Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin”. Endocrinology 114 (6): 2100–6. (1984). doi:10.1210/endo-114-6-2100. PMID 6539197.
- ^ “Pharmacology of estrogens and progestogens: influence of different routes of administration”. Climacteric 8 Suppl 1: 3–63. (2005). doi:10.1080/13697130500148875. PMID 16112947.
- ^ “The significance of drug interactions with human TeBG and CBG under physiological conditions: a new approach”. J. Steroid Biochem. 15: 487–90. (December 1981). doi:10.1016/0022-4731(81)90319-8. PMID 7200170.
- ^ “Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma”. J. Clin. Endocrinol. Metab. 53 (1): 58–68. (July 1981). doi:10.1210/jcem-53-1-58. PMID 7195404.
[続きの解説]
「性ホルモン結合グロブリン」の続きの解説一覧
- 1 性ホルモン結合グロブリンとは
- 2 性ホルモン結合グロブリンの概要
- 3 遺伝子
- 4 プロモーター活性化
- 5 血中濃度
- 6 関連文献
- 7 外部リンク
- sex hormone binding globulinのページへのリンク
