ICAM-1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/14 01:09 UTC 版)
ICAM-1または細胞間接着分子1（さいぼうかんせっちゃくぶんし1、英: intercellular adhesion molecule 1）は、ヒトではICAM1遺伝子にコードされるタンパク質である[5][6]。CD54（cluster of differentiation 54）としても知られる。ICAM-1は細胞表面の糖タンパク質であり、一般的には血管内皮細胞と免疫系の細胞で発現している。CD11a/CD18、CD11b/CD18型のインテグリンに結合し、またライノウイルスが呼吸上皮に進入する際の受容体としても利用される[7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000090339 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037405 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ “Entrez Gene: intercellular adhesion molecule 1”. 2021年5月4日閲覧。
- ^ a b “The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand”. Proceedings of the National Academy of Sciences 95 (8): 4140–45. (Apr 1998). Bibcode: 1998PNAS...95.4140B. doi:10.1073/pnas.95.8.4140. PMC 22455. PMID 9539703.
- ^ “A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1”. Journal of Immunology 137 (4): 1270–4. (August 1986). PMID 3525675.
- ^ “ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow”. Blood 106 (2): 584–92. (July 2005). doi:10.1182/blood-2004-12-4942. PMC 1635241. PMID 15811956.
- ^ Langer, Harald F.; Chavakis, Triantafyllos (2009-07). “Leukocyte-endothelial interactions in inflammation”. Journal of Cellular and Molecular Medicine 13 (7): 1211–1220. doi:10.1111/j.1582-4934.2009.00811.x. ISSN 1582-4934. PMC 2861890. PMID 19538472.
- ^ “Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis”. Arthritis Research & Therapy 16 (1): R42. (February 2014). doi:10.1186/ar4471. PMC 3978678. PMID 24490631.
- ^ “Intercellular adhesion molecules (ICAMs) and spermatogenesis”. Human Reproduction Update 19 (2): 167–86. (2013). doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428.
- ^ “Many rhinovirus serotypes share the same cellular receptor”. Journal of Virology 51 (2): 340–45. (Aug 1984). doi:10.1128/JVI.51.2.340-345.1984. PMC 254443. PMID 6086949.
- ^ Berendt, A. R.; Simmons, D. L.; Tansey, J.; Newbold, C. I.; Marsh, K. (1989-09-07). “Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum”. Nature 341 (6237): 57–59. doi:10.1038/341057a0. ISSN 0028-0836. PMID 2475784.
- ^ “ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion”. Journal of Immunology 163 (2): 668–74. (Jul 1999). PMID 10395656.
- ^ “Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts”. Journal of the American Society of Nephrology 14 (1): 116–27. (Jan 2003). doi:10.1097/01.ASN.0000040595.35207.62. PMID 12506144.
- ^ “Detection of soluble E-selectin, ICAM-1, VCAM-1, and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage”. Journal of Neurosurgery 89 (4): 559–67. (Oct 1998). doi:10.3171/jns.1998.89.4.0559. PMID 9761049.
- ^ “Inflammatory cell adhesion molecules in ischemic cerebrovascular disease”. Stroke: A Journal of Cerebral Circulation 33 (8): 2115–22. (Aug 2002). doi:10.1161/01.STR.0000021902.33129.69. PMID 12154274.
- ^ Shukla, Shakti Dhar; Mahmood, Malik Quasir; Weston, Steven; Latham, Roger; Muller, Hans Konrad; Sohal, Sukhwinder Singh; Walters, Eugene Haydn (2017-01-05). “The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)”. Respiratory Research 18 (1): 6. doi:10.1186/s12931-016-0483-8. ISSN 1465-993X. PMC 5217320. PMID 28056984.
- ^ “Viral targeting of non-muscle invasive bladder cancer and priming of anti-tumour immunity following intravesical Coxsackievirus A21”. Clinical Cancer Research 25 (19): 5818–5831. (July 2019). doi:10.1158/1078-0432.CCR-18-4022. PMID 31273010.
- ^ “Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions”. The Journal of Neuroscience 32 (12): 4004–16. (March 2012). doi:10.1523/JNEUROSCI.4628-11.2012. PMC 3325902. PMID 22442067.
- ^ a b “Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state”. The Journal of Biological Chemistry 276 (18): 14642–48. (May 2001). doi:10.1074/jbc.M100600200. PMID 11279101.
- ^ “Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation”. Cell 112 (1): 99–111. (Jan 2003). doi:10.1016/S0092-8674(02)01257-6. PMC 4372089. PMID 12526797.
- ^ “Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction”. Peptides 22 (12): 1955–62. (Dec 2001). doi:10.1016/S0196-9781(01)00546-0. PMID 11786177.
- ^ “ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity”. Journal of Immunology 162 (11): 6613–20. (Jun 1999). PMID 10352278.
- ^ “A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)”. The Journal of Biological Chemistry 270 (32): 19008–16. (Aug 1995). doi:10.1074/jbc.270.32.19008. PMID 7642561.
- ^ “Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate”. The Journal of Biological Chemistry 273 (34): 21893–900. (Aug 1998). doi:10.1074/jbc.273.34.21893. PMID 9705328.
[続きの解説]
「ICAM-1」の続きの解説一覧
- 1 ICAM-1とは
- 2 ICAM-1の概要
- 3 構造
- 4 相互作用
- icam1のページへのリンク
