プロテインチロシンホスファターゼ
(Protein-tyrosine-phosphatase から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/11/01 14:46 UTC 版)
プロテインチロシンホスファターゼ（英: protein tyrosine phosphatase、EC 3.1.3.48、系統名: protein-tyrosine-phosphate phosphohydrolase、略称: PTP）または単にチロシンホスファターゼは、タンパク質中のリン酸化されたチロシン残基からリン酸基を除去する酵素のグループである。すなわち、次の反応を触媒する。
- ^ “Protein tyrosine phosphatases: mechanisms of catalysis and regulation”. Curr Opin Chem Biol 2 (5): 633–41. (2018). doi:10.1016/S1367-5931(98)80095-1. PMID 9818190.
- ^ “Receptor and nonreceptor protein tyrosine phosphatases in the nervous system”. Cell. Mol. Life Sci. 60 (11): 2465–82. (2020). doi:10.1007/s00018-003-3123-7. PMID 14625689.
- ^ a b “Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model”. Proceedings of the National Academy of Sciences of the United States of America 107 (44): 19014–9. (Nov 2018). Bibcode: 2010PNAS..10719014Z. doi:10.1073/pnas.1013543107. PMC 2973892. PMID 20956308.
- ^ a b “Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model”. Genes, Brain and Behavior 11 (5): 586–600. (Jul 2019). doi:10.1111/j.1601-183X.2012.00781.x. PMC 3922131. PMID 22405502.
- ^ “Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61”. The Journal of Neuroscience 30 (17): 5948–57. (Apr 2022). doi:10.1523/JNEUROSCI.0157-10.2010. PMC 2868326. PMID 20427654.
- ^ “An overview of the protein tyrosine phosphatase superfamily”. Curr Top Med Chem 3 (7): 739–48. (2017). doi:10.2174/1568026033452302. PMID 12678841.
- ^ “Protein tyrosine phosphatases in the human genome”. Cell 117 (6): 699–711. (2020). doi:10.1016/j.cell.2004.05.018. PMID 15186772.
- ^ “The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications”. Translational Psychiatry 2 (7): e137. (2021). doi:10.1038/tp.2012.63. PMC 3410627. PMID 22781170.
- ^ “STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease”. Proceedings of the National Academy of Sciences of the United States of America 112 (4): 1202–7. (Jan 2018). Bibcode: 2015PNAS..112.1202K. doi:10.1073/pnas.1417423112. PMC 4313846. PMID 25583483.
- ^ “Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity”. The Journal of Neuroscience 31 (22): 8150–62. (Jun 2021). doi:10.1523/JNEUROSCI.3446-10.2011. PMC 3472648. PMID 21632937.
- ^ “Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model”. Human Molecular Genetics 21 (17): 3739–52. (Sep 2020). doi:10.1093/hmg/dds154. PMC 3412376. PMID 22523092.
- ^ “Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia”. The Journal of Neuroscience 33 (45): 17814–26. (Nov 2020). doi:10.1523/JNEUROSCI.2346-12.2020. PMC 3818554. PMID 24198371.
- ^ “Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase”. Proceedings of the National Academy of Sciences of the United States of America 108 (16): 6650–5. (Apr 2020). Bibcode: 2011PNAS..108.6650H. doi:10.1073/pnas.1017856108. PMC 3081035. PMID 21464302.
- ^ “Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption”. Journal of Neurochemistry 129 (6): 1024–34. (Jun 2019). doi:10.1111/jnc.12701. PMC 4055745. PMID 24588427.
- ^ “A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes”. The Journal of Neuroscience 32 (22): 7550–62. (May 2022). doi:10.1523/JNEUROSCI.5902-11.2022. PMC 6703597. PMID 22649233.
- ^ “Striatal-enriched protein tyrosine phosphatase-STEPs toward understanding chronic stress-induced activation of corticotrophin releasing factor neurons in the rat bed nucleus of the stria terminalis”. Biological Psychiatry 74 (11): 817–26. (Dec 2020). doi:10.1016/j.biopsych.2013.07.032. PMC 3818357. PMID 24012328.
- ^ “Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase”. J. Biol. Chem. 267 (15): 10856–10865. (2023). doi:10.1016/S0021-9258(19)50097-7. PMID 1587862.
- ^ “Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase”. Protein Sci. 1 (6): 710–721. (1992). doi:10.1002/pro.5560010603. PMC 2142247. PMID 1304913.
- ^ “Genomics and evolution of protein phosphatases”. Science Signaling 10 (474): eaag1796. (April 2023). doi:10.1126/scisignal.aag1796. PMID 28400531.
- ^ Plaxton, William C.; McManus, Michael T. (2020). Control of primary metabolism in plants. Wiley-Blackwell. pp. 130–. ISBN 978-1-4051-3096-7 2020年12月12日閲覧。
- ^ “The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1”. Protein Sci. 15 (6): 1500–1505. (2006). doi:10.1110/ps.062128706. PMC 2242534. PMID 16672235.
- ^ Perrimon N, Johnson MR, Perkins LA, Melnick MB (2018). “The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila”. Dev. Biol. 180 (1): 63–81. doi:10.1006/dbio.1996.0285. PMID 8948575.
- ^ “The structure and mechanism of protein phosphatase s: insights into catalysis and regulation”. Annu. Rev. Biophys. Biomol. Struct. 27 (1): 133–64. (2021). doi:10.1146/annurev.biophys.27.1.133. PMID 9646865.
- ^ “The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase”. Nature 370 (6490): 575–8. (August 1994). Bibcode: 1994Natur.370..575S. doi:10.1038/370575a0. PMID 8052313.
- ^ “Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate”. Nature 370 (6490): 571–5. (August 1994). Bibcode: 1994Natur.370..571S. doi:10.1038/370571a0. hdl:2027.42/62819. PMID 8052312.
- ^ “Crystal structure of the dual specificity protein phosphatase VHR”. Science 272 (5266): 1328–31. (May 1996). Bibcode: 1996Sci...272.1328Y. doi:10.1126/science.272.5266.1328. PMID 8650541.
- ^ “Structural and functional characterization of a novel phosphatase from the Arabidopsis thaliana gene locus At1g05000”. Proteins 73 (1): 241–53. (October 2008). doi:10.1002/prot.22041. PMC 4437517. PMID 18433060.
- ^ “Protein tyrosine phosphatases and the immune response”. Nat. Rev. Immunol. 5 (1): 43–57. (2018). doi:10.1038/nri1530. PMID 15630428.
- ^ “Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum”. Proceedings of the National Academy of Sciences of the United States of America 88 (16): 7242–6. (Aug 2021). Bibcode: 1991PNAS...88.7242L. doi:10.1073/pnas.88.16.7242. PMC 52270. PMID 1714595.
- ^ “STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum”. The Journal of Neuroscience 16 (24): 7821–31. (Dec 2021). doi:10.1523/JNEUROSCI.16-24-07821.2021. PMC 6579237. PMID 8987810.
- ^ “A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures”. The Journal of Neuroscience 13 (7): 3064–74. (Jul 2021). doi:10.1523/JNEUROSCI.13-07-03064.2021. PMC 6576687. PMID 8331384.
[続きの解説]
「プロテインチロシンホスファターゼ」の続きの解説一覧
- 1 プロテインチロシンホスファターゼとは
- 2 プロテインチロシンホスファターゼの概要
- 3 外部リンク
- プロテインチロシンホスファターゼのページへのリンク
