眼窩前頭皮質とは - わかりやすく解説 Weblio辞書

眼窩前頭皮質

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/12/14 18:00 UTC 版)

眼窩前頭皮質、前頭眼窩野、前頭前野眼窩部（がんかぜんとうひしつ、ぜんとうがんかや、ぜんとうぜんやがんかぶ　英: orbitofrontal cortex, OFC orbital prefrontal cortex, oPFC）は、脳の前頭前野の腹側表面^[1]で、意思決定に重要な役割を果たす^[2]。

出典

^ ^a ^b ^c ^d ^e Nicolas W. Schuck, Robert C. Wilson, Yael Niv A State Representation for Reinforcement Learning and Decision-making in the Orbitofrontal Cortex. bioRXiv (2017)
^ ^a ^b ^c Andrew M. Wikenheiser and Geoffrey Schoenbaum Over the river, through the woodscognitive maps in the hippocampus and orbitofrontal cortex. Nature Reviews Neuroscience (2016)
^ Lopatina N¹, Sadacca BF¹, McDannald MA², Styer CV¹, Peterson JF¹, Cheer JF³, Schoenbaum G¹ Ensembles in medial and lateral orbitofrontal cortex construct cognitive maps emphasizing different features of the behavioral landscape. APA PsycNET (2017)
^ ^a ^b Kringelbach, M. L. (2005) "The orbitofrontal cortex: linking reward to hedonic experience." Nature Reviews Neuroscience 6: 691-702.
^ Bechara, A.; Damasio, A. R.; Damasio H. & Anderson, S.W. (1994) "Insensitivity to future consequences following damage to human prefrontal cortex". Cognition 50: 7-15.
^ Snowden, J. S.; Bathgate, D.; Varma, A.; Blackshaw, A.; Gibbons, Z. C. & Neary. D. (2001) "Distinct behavioural profiles in frontotemporal dementia and semantic dementia". J Neurol Neurosurg Psychiatry 70: 323-332.
^ J. Wilson, M. Jenkinson, I. E. T. de Araujo, Morten L. Kringelbach, E. T. Rolls, & Peter Jezzard (October 2002). “Fast, fully automated global and local magnetic field optimization for fMRI of the human brain”. NeuroImage 17 (2): 967–976. doi:10.1016/S1053-8119(02)91172-9. PMID 12377170.
^ Kringelbach, M. L. and Rolls, E. T. (2004). “The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology”. Progress in Neurobiology 72: 341–372. doi:10.1016/j.pneurobio.2004.03.006.
^ ^a ^b ^c ^d ^e Alicia Izquierdo Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making Journal of Neuroscience (2017)
^ Geoffrey Schoenbaum et al. Medial Orbitofrontal Neurons Preferentially Signal Cues Predicting Changes in Reward during Unblocking (Journal of Neuroscience (2016)
^ Marios C. Panayi, Simon Killcross (2018). “Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits”. eLife.
^ Geoffrey Schoenbaum et al.Orbitofrontal inactivation impairs reversal of Pavlovian learning by interfering with disinhibition of responding for previously unrewarded cues. Eur J Neuroscience (2009)
^ ^a ^b Yael Niv et al. Orbitofrontal Cortex as a Cognitive Map of Task Space Neuron (2014)
^ ^a ^b Geoffrey Shoenbaum et al. Neural Estimates of Imagined Outcomes in the Orbitofrontal Cortex Drive Behavior and Learning Neuron (2013)
^ ^a ^b Geoffrey Schoenbaum et al. Lateral Orbitofrontal Inactivation Dissociates Devaluation-Sensitive Behavior and Economic Choice. Neuron (2017)
^ Bernardo Balleine et al. The orbitofrontal cortex, predicted value, and choice. Ann N Y Acad Sci. (2011)
^ Thinking Outside the Box: Orbitofrontal Cortex, Imagination, and How We Can Treat Addiction (Geoffrey Schoenbaum et al. Neuropsycopharmacology 2016)
^ ^a ^b Geoffrey Schoenbaum et al. Ventral Striatum and Orbitofrontal Cortex Are Both Required for Model-Based, But Not Model-Free, Reinforcement Learning Journal of Neuroscience (2011)
^ Adam Kepecs et al. Orbitofrontal Cortex Is Required for Optimal Waiting Based on Decision Confidence. Neuron (2014)
^ ^a ^b Bernard Balleine et al. Medial Orbitofrontal Cortex Mediates Outcome Retrieval in Partially Observable Task Situations Neuron (2015)
^ ^a ^b Elisabeth Murray et al. The Orbitofrontal Oracle:Cotical Mechanism for the Prediction and Evaluation of Specific Behavioral Outcomes Neuron (2014)
^ ^a ^b Houri Hintiryan, Nicholas N Foster, Ian Bowman, Maxwell Bay, Monica Y Song, Lin Gou, Seita Yamashita, Michael S Bienkowski, Brian Zingg, Muye Zhu, X William Yang, Jean C Shih, Arthur W Toga & Hong-Wei Dong (2016). “The mouse cortico-striatal projectome”. Nature Neuroscience.
^ AND A. HOLMES et al. THE NEURAL BASIS OF REVERSAL LEARNING: AN UPDATED PERSPECTIVE Neuroscience (2017)
^ 小川　正晃　報酬に基づく意思決定を司る神経回路機能の解明　　上原記念生命科学財団研究報告集, 29 (2015)
^ Emily T Baltz, Ege A Yalcinbas, Rafael Renteria, Christina M Gremel (2018). “Orbital frontal cortex updates state-induced value change for decision-making”. eLIFE.
^ Sean B. Ostlundand, Bernard W.Balleine Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning Journal of Neuroscience (2007)
^ ^a ^b Carlos Brody et al. Value Representations in Orbitofrontal Cortex Drive Learning, but not Choice. bioRXiv (2018)
^ Thinking Outside the Box: Orbitofrontal Cortex, Imagination, and How We Can Treat Addiction (Geoffrey Schoenbaum et al. Neuropsycopharmacology 2016)
^ Carlos Brody et al. Dorsal hippocampus contributes to model-based planning Nature Neuroscience (2017)
^ Geoffrey Schoenbaum et al. Optogenetic Blockade of Dopamine Transients Prevents Learning Induced by Changes in Reward Features. Current Biology (2017）
^ Geoffrey Schoenbaum et al. Dopamine transients are sufficient and necessary for acquisition of model-based associations Nature Neuroscience (2017)
^ Geoffrey Schoenbaum et al. Effects of inference on dopaminergic prediction errors depend on orbitofrontal processing. Behavior Neuroscience (2017)
^ ^a ^b ^c Geoffrey Shoenbaum et al. Lateral orbitofrontal neurons acquire responses to upshifted, downshifted, or blocked cues during unblocking. eLife (2015)
^ ^a ^b ^c Jonathan D. Wallis et al. Double dissociation of value computations in orbitofrontal and anterior cingulate neurons. Nature Neuroscience (2017)
^ Geoffrey Schoenbaum et al. Risk-Responsive Orbitofrontal Neurons Track Acquired Salience. Neuron (2013)
^ Wassum, Kate M.; Greenfield, Venuz Y.; Murphy, Michael D.; Shieh, Christine; Malvaez, Melissa (2019-05). “Distinct cortical–amygdala projections drive reward value encoding and retrieval” (英語). Nature Neuroscience 22 (5): 762–769. doi:10.1038/s41593-019-0374-7. ISSN 1546-1726.
^ ^a ^b Geoffrey Schoenbaum et al, Supression of Ventral Hippocampus Output impairs Integrated Orbitofrontal Encoding of Task. Structure Neuron (2017)
^ Kate Wassum et al. Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations Journal of Neuroscience (2017)
^ Geoffrey Schoenbaum et al. Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons. Nature Communications (2017)
^ ^a ^b Geoffrey Schoenbaum et al. Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex Nature Neuroscience (2011)
^ ^a ^b Drew C. Schreiner & Christina M. Gremel (2018). “Orbital Frontal Cortex Projections to Secondary Motor Cortex Mediate Exploitation of Learned Rules”. Scientific Report.
^ ^a ^b Lüscher, Christian; Flakowski, Jérôme; Harada, Masaya; Ridouane Achargui; Loureiro, Michaël; Zessen, Ruud Van; Hiver, Agnès; Pascoli, Vincent (2018-12). “Stochastic synaptic plasticity underlying compulsion in a model of addiction” (英語). Nature 564 (7736): 366–371. doi:10.1038/s41586-018-0789-4. ISSN 1476-4687.
^ Deisseroth, Karl; Ramakrishnan, Charu; Pak, Sally; Quirin, Sean; Ye, Li; Raffiee, Misha; Marshel, James H.; Kim, Christina K. et al. (2019-01). “Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour” (英語). Nature 565 (7741): 645–649. doi:10.1038/s41586-018-0866-8. ISSN 1476-4687.
^ Rolls, E. T.; Hornak, J.; Wade, D. & McGrath, J. (1994) "Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage." J Neurol Neurosurg Psychiatry 57: 1518-1524.
^ Bechara, A.; Damasio, A. R.; Damasio H. & Anderson, S.W. (1994) "Insensitivity to future consequences following damage to human prefrontal cortex". Cognition 50: 7-15.
^ Stone, V.E.; Baron-Cohen, S. & Knight, R. T. (1998a) "Frontal Lobe Contributions to Theory of Mind." Journal of Medical Investigation 10: 640-656.