ラムナン硫酸
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/16 16:15 UTC 版)
ラムナン硫酸（ラムナンりゅうさん、rhamnan sulfate）は、緑藻類のヒトエグサ、スジアオノリ、アナアオサ[1][2]や微細藻類のスピルリナ [3]などに含まれる多糖類の一種。その中でもヒトエグサでの含有量が最も高い[1]。平均分子量は数万から数百万、主な構成糖はL-ラムノースと硫酸化L-ラムノースで、硫酸化多糖でもある。ラムナン硫酸にはまだまだ未知の部分が多く、これからの研究・発展が期待される多糖である。
- ^ a b c Maeda M, Uehara T, Harada N, Sekiguchi M, Hiraoka A. Heparinoid-active sulphated polysaccharides from Monostroma nitidum and their distribution in the chlorophyta. Phytochemistry. 1991;30(11):3611-4. doi: 10.1016/0031-9422(91)80076-D.
- ^ a b Lee J-B, Yamagaki T, Maeda M, Nakanishi H. Rhamnan sulfate from cell walls of Monostroma latissimum Phytochemistry. 1998;48(6):921-5. doi: 10.1016/S0031-9422(97)00927-8.
- ^ Lee JB, Srisomporn P, Hayashi K, Tanaka T, Sankawa U, Hayashi T. Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina platensis, on antiviral activity. Chem Pharm Bull (Tokyo). 2001;49(1):108-10. doi: 10.1248/cpb.49.108.
- ^ a b c Harada N, Maeda M. Chemical structure of antithrombin-active Rhamnan sulfate from Monostrom nitidum. Biosci Biotechnol Biochem. 1998;62(9):1647-52. doi: 10.1271/bbb.62.1647.
- ^ Suzuki K, Terasawa M. Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa). Mar Drugs. 2020;18(4). doi: 10.3390/md18040228.
- ^ a b c d Okamoto T, Akita N, Terasawa M, Hayashi T, Suzuki K. Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells. J Nat Med. 2019;73(3):614-9. doi: 10.1007/s11418-019-01289-5.
- ^ Li H, Mao W, Hou Y, Gao Y, Qi X, Zhao C, et al. Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of sulfated rhamnan from Monostroma latissimum. Bioresour Technol. 2012;114:414-8. doi: 10.1016/j.biortech.2012.03.025.
- ^ a b Li N, Liu X, He X, Wang S, Cao S, Xia Z, et al. Structure and anticoagulant property of a sulfated polysaccharide isolated from the green seaweed Monostroma angicava. Carbohydr Polym. 2017;159:195-206. doi: 10.1016/j.carbpol.2016.12.013.
- ^ Liu X, Hao J, He X, Wang S, Cao S, Qin L, et al. A rhamnan-type sulfated polysaccharide with novel structure from Monostroma angicava Kjellm (Chlorophyta) and its bioactivity. Carbohydr Polym. 2017;173:732-48. doi: 10.1016/j.carbpol.2017.06.031.
- ^ a b Liu X, Du P, Liu X, Cao S, Qin L, He M, et al. Anticoagulant Properties of a Green Algal Rhamnan-type Sulfated Polysaccharide and Its Low-molecular-weight Fragments Prepared by Mild Acid Degradation. Mar Drugs. 2018;16(11). doi: 10.3390/md16110445.
- ^ a b Liu X, Wang S, Cao S, He X, Qin L, He M, et al. Structural Characteristics and Anticoagulant Property In Vitro and In Vivo of a Seaweed Sulfated Rhamnan. Mar Drugs. 2018;16(7). doi: 10.3390/md16070243.
- ^ Yamashiro Y, Nakamura M, Yogi T, Teruya T, Konishi T, Uechi S, et al. Anticoagulant Activity of Rhamnan Sulfate Isolated from Commercially Cultured Monostroma nitidum. Int J Biomed Mater Res. 2017;5(3):37-43. doi: 10.11648/j.ijbmr.20170503.12.
- ^ Lee JB, Hayashi K, Hayashi T, Sankawa U, Maeda M. Antiviral activities against HSV-1, HCMV, and HIV-1 of rhamnan sulfate from Monostroma latissimum. Planta Med. 1999;65(5):439-41. doi: 10.1055/s-2006-960804.
- ^ Lee JB, Hayashi K, Maeda M, Hayashi T. Antiherpetic activities of sulfated polysaccharides from green algae. Planta Med. 2004;70(9):813-7. doi: 10.1055/s-2004-827228.
- ^ a b c Terasawa M, Hayashi K, Lee JB, Nishiura K, Matsuda K, Hayashi T, et al. Anti-Influenza A Virus Activity of Rhamnan Sulfate from Green Algae Monostroma nitidum in Mice with Normal and Compromised Immunity. Mar Drugs. 2020;18(5):254. doi: 10.3390/md18050254.
- ^ Wang S, Wang W, Hao C, Yunjia Y, Qin L, He M, et al. Antiviral activity against enterovirus 71 of sulfated rhamnan isolated from the green alga Monostroma latissimum. Carbohydr Polym. 2018;200:43-53. doi: 10.1016/j.carbpol.2018.07.067.
- ^ Zang L, Shimada Y, Tanaka T, Nishimura N. Rhamnan sulphate from Monostroma nitidum attenuates hepatic steatosis by suppressing lipogenesis in a diet-induced obesity zebrafish model. J Funct Foods. 2015;17:364-70. doi: 10.1016/j.jff.2015.05.041.
- ^ 西川政勝, 三井雅之, 梅田幸嗣, 北岡義国, 高橋良枝, 田中茂男. 正常高値および軽症高コレステロール血症者における食用海藻ヒトエグサ抽出硫酸多糖類の血中コレステロールにおよぼす影響 新薬と臨牀. 2006;55(11):1763 -70.
- ^ 上村佑也, 橋口健司, 長田裕子, 坂智秀, 吉田睦子, 牧野陽介, et al. 緑藻ヒトエグサの血糖値上昇抑制作用. 日本食品科学工学会誌. 2010;57(10):441-5. doi: 10.3136/nskkk.57.441.
- ^ 山元裕太, 大薗紅葉, 大石智博, 大島賢治, 満生慎二, 柿原秀己, et al. 養殖ヒトエグサ由来ラムナン硫酸のヒアルロニダーゼ阻害活性. 日本食品科学工学会誌. 2016;63(11):545-9. doi: 10.3136/nskkk.63.545.
[続きの解説]
「ラムナン硫酸」の続きの解説一覧
- 1 ラムナン硫酸とは
- 2 ラムナン硫酸の概要
- 3 外部リンク
ラムナン硫酸と同じ種類の言葉
固有名詞の分類
- ラムナン硫酸のページへのリンク
