ニック (DNA)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/25 06:52 UTC 版)
ニック（英: nick）は、二本鎖DNA分子中で、1本の鎖の隣接するヌクレオチドの間のホスホジエステル結合が存在せず、不連続な状態を指す。一般的に、ニックは損傷もしくは酵素作用によって形成される。ニックは複製時のDNA鎖の巻き戻しを可能にし、またリーディング鎖とラギング鎖の双方のエラーを修復するDNAミスマッチ修復機構にも関与していると考えられている[1]。
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- ^ “Configuration Transitions of Free Circular DNA System Induced by Nicks” (英語). www.hindawi.com. 2022年9月19日閲覧。
- ^ a b Huang, Shar-Yin Naomi; Ghosh, Sanchari; Pommier, Yves (2015-05-29). “Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites”. The Journal of Biological Chemistry 290 (22): 14068–14076. doi:10.1074/jbc.M115.653345. ISSN 1083-351X. PMC 4447978. PMID 25887397.
- ^ Racko, Dusan; Benedetti, Fabrizio; Dorier, Julien; Burnier, Yannis; Stasiak, Andrzej (2015-07-06). “Generation of supercoils in nicked and gapped DNA drives DNA unknotting and postreplicative decatenation”. Nucleic Acids Research 43 (15): 7229–7236. doi:10.1093/nar/gkv683. ISSN 0305-1048. PMC 4551925. PMID 26150424.
- ^ a b Hays, J. B.; Zimm, B. H. (1970-03-14). “Flexibility and stiffness in nicked DNA”. Journal of Molecular Biology 48 (2): 297–317. doi:10.1016/0022-2836(70)90162-2. ISSN 0022-2836. PMID 5448592.
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- ^ Matson, S. W.; Nelson, W. C.; Morton, B. S. (1993-05). “Characterization of the reaction product of the oriT nicking reaction catalyzed by Escherichia coli DNA helicase I”. Journal of Bacteriology 175 (9): 2599–2606. doi:10.1128/jb.175.9.2599-2606.1993. ISSN 0021-9193. PMC 204561. PMID 8386720.
- ^ Grohmann, Elisabeth; Muth, Günther; Espinosa, Manuel (2003-06). “Conjugative plasmid transfer in gram-positive bacteria”. Microbiology and molecular biology reviews: MMBR 67 (2): 277–301, table of contents. doi:10.1128/MMBR.67.2.277-301.2003. ISSN 1092-2172. PMC 156469. PMID 12794193.
[続きの解説]
「ニック (DNA)」の続きの解説一覧
- 1 ニック (DNA)とは
- 2 ニック (DNA)の概要
- ニック (DNA)のページへのリンク
