シナプス小胞とは? わかりやすく解説

Weblio 辞書 > 同じ種類の言葉 > ヘルスケア > 体組織 > 小胞 > シナプス小胞の意味・解説 

シナプス小胞

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/04/21 09:21 UTC 版)

シナプス小胞(シナプスしょうほう、: synaptic vesicle, neurotransmitter vesicle)は、神経細胞シナプスで放出されるさまざまな神経伝達物質を貯蔵している小胞である。小胞の内容物の放出は電位依存性カルシウムチャネルによって調節されている。小胞は神経細胞間での活動電位の伝播に必要不可欠であり、細胞で常に再形成されている。軸索中では、こうした小胞は軸索終末(axon terminal、terminal bouton)に保持されている。10分間、0.2 Hzの刺激を行うことで、1つの軸索終末当たり最大130個の小胞が放出される[1]。ヒトの脳の視覚野では、シナプス小胞の直径は39.5±5.1 nmである[2]


  1. ^ Ikeda, K; Bekkers, JM (2009). “Counting the number of releasable synaptic vesicles in a presynaptic terminal”. Proc Natl Acad Sci U S A 106 (8): 2945–50. Bibcode2009PNAS..106.2945I. doi:10.1073/pnas.0811017106. PMC 2650301. PMID 19202060. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650301/. 
  2. ^ Qu, Lei; Akbergenova, Yulia; Hu, Yunming; Schikorski, Thomas (2009-06-01). “Synapse-to-synapse variation in mean synaptic vesicle size and its relationship with synaptic morphology and function”. The Journal of Comparative Neurology 514 (4): 343–352. doi:10.1002/cne.22007. ISSN 1096-9861. PMID 19330815. https://pubmed.ncbi.nlm.nih.gov/19330815. 
  3. ^ Tonna, Noemi; Bianco, Fabio; Matteoli, Michela; Cagnoli, Cinzia; Antonucci, Flavia; Manfredi, Amedea; Mauro, Nicolò; Ranucci, Elisabetta et al. (2014). “A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing”. Science and Technology of Advanced Materials 15 (4): 045007. Bibcode2014STAdM..15d5007T. doi:10.1088/1468-6996/15/4/045007. PMC 5090696. PMID 27877708. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090696/. 
  4. ^ a b Benfenati, F.; Greengard, P.; Brunner, J.; Bähler, M. (1989). “Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers”. The Journal of Cell Biology 108 (5): 1851–1862. doi:10.1083/jcb.108.5.1851. PMC 2115549. PMID 2497105. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115549/. 
  5. ^ Li, Huinan; Wu, Cheng; Aramayo, Rodolfo; Sachs, Matthew S.; Harlow, Mark L. (2015-10-08). “Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA)” (英語). Scientific Reports 5: 14918. Bibcode2015NatSR...514918L. doi:10.1038/srep14918. PMC 4597359. PMID 26446566. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597359/. 
  6. ^ “Transmitter Release”. Principles of Neural Science (4th ed.). New York: McGraw-Hill. (2000). ISBN 978-0-8385-7701-1. https://archive.org/details/isbn_9780838577011 
  7. ^ Rizzoli, Silvio O; Betz, William J (January 2005). “Synaptic vesicle pools”. Nature Reviews Neuroscience 6 (1): 57–69. doi:10.1038/nrn1583. PMID 15611727. 
  8. ^ Rose, Tobias; Schoenenberger, Philipp; Jezek, Karel; Oertner, Thomas G. (2013). “Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses”. Neuron 77 (6): 1109–1121. doi:10.1016/j.neuron.2013.01.021. PMID 23522046. 
  9. ^ Xue, Lei; Sheng, Jiansong; Wu, Xin-Sheng; Wu, Wei; Luo, Fujun; Shin, Wonchul; Chiang, Hsueh-Cheng; Wu, Ling-Gang (2013-05-15). “Most Vesicles in a Central Nerve Terminal Participate in Recycling”. Journal of Neuroscience 33 (20): 8820–8826. doi:10.1523/jneurosci.4029-12.2013. PMC 3710729. PMID 23678124. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710729/. 
  10. ^ a b Südhof, T. C. (2004). “The Synaptic Vesicle Cycle”. Annual Review of Neuroscience 27: 509–547. doi:10.1146/annurev.neuro.26.041002.131412. PMID 15217342. https://semanticscholar.org/paper/922575e7e1f2f98edb3b31489b5a7e1e100516d0. 
  11. ^ Tien, N. W.; Wu, G. H.; Hsu, C. C.; Chang, C. Y.; Wagner, O. I. (2011). “Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. Elegans neurons”. Neurobiology of Disease 43 (2): 495–506. doi:10.1016/j.nbd.2011.04.023. PMID 21569846. 
  12. ^ Arimoto, M.; Koushika, S. P.; Choudhary, B. C.; Li, C.; Matsumoto, K.; Hisamoto, N. (2011). “The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein”. Journal of Neuroscience 31 (6): 2216–2224. doi:10.1523/JNEUROSCI.2653-10.2011. PMC 6633058. PMID 21307258. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633058/. 
  13. ^ Sandoval, G. M.; Duerr, J. S.; Hodgkin, J.; Rand, J. B.; Ruvkun, G. (2006). “A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. Elegans”. Nature Neuroscience 9 (5): 599–601. doi:10.1038/nn1685. PMID 16604067. 
  14. ^ Abraham, C.; Bai, L.; Leube, R. E. (2011). “Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans”. Neuroscience 190: 75–88. doi:10.1016/j.neuroscience.2011.05.069. PMID 21689733. 
  15. ^ Hammarlund, Marc; Palfreyman, Mark T; Watanabe, Shigeki; Olsen, Shawn; Jorgensen, Erik M (August 2007). “Open Syntaxin Docks Synaptic Vesicles”. PLoS Biology 5 (8). doi:10.1371/journal.pbio.0050198. ISSN 1544-9173. PMC 1914072. PMID 17645391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914072/. 
  16. ^ Kaeser, Pascal S.; Deng, Lunbin; Wang, Yun; Dulubova, Irina; Liu, Xinran; Rizo, Josep; Südhof, Thomas C. (2011). “RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction”. Cell 144 (2): 282–295. doi:10.1016/j.cell.2010.12.029. PMC 3063406. PMID 21241895. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063406/. 
  17. ^ Lin, X. G.; Ming, M.; Chen, M. R.; Niu, W. P.; Zhang, Y. D.; Liu, B.; Jiu, Y. M.; Yu, J. W. et al. (2010). “UNC-31/CAPS docks and primes dense core vesicles in C. Elegans neurons”. Biochemical and Biophysical Research Communications 397 (3): 526–531. doi:10.1016/j.bbrc.2010.05.148. PMID 20515653. 
  18. ^ a b Breckenridge, L. J.; Almers, W. (1987). “Currents through the fusion pore that forms during exocytosis of a secretory vesicle”. Nature 328 (6133): 814–817. Bibcode1987Natur.328..814B. doi:10.1038/328814a0. PMID 2442614. 
  19. ^ Heuser, J. E.; Reese, T. S. (1973). “Evidence for Recycling of Synaptic Vesicle Membrane During Transmitter Release at the Frog Neuromuscular Junction”. The Journal of Cell Biology 57 (2): 315–344. doi:10.1083/jcb.57.2.315. PMC 2108984. PMID 4348786. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2108984/. 
  20. ^ Miller, T. M.; Heuser, J. E. (1984). “Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction”. The Journal of Cell Biology 98 (2): 685–698. doi:10.1083/jcb.98.2.685. PMC 2113115. PMID 6607255. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2113115/. 
  21. ^ Ryan, T. A.; Smith, S. J.; Reuter, H. (1996). “The timing of synaptic vesicle endocytosis”. Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5567–5571. Bibcode1996PNAS...93.5567R. doi:10.1073/pnas.93.11.5567. PMC 39287. PMID 8643616. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39287/. 
  22. ^ Xu, H.; Zick, M.; Wickner, W. T.; Jun, Y. (2011). “A lipid-anchored SNARE supports membrane fusion”. Proceedings of the National Academy of Sciences 108 (42): 17325–17330. Bibcode2011PNAS..10817325X. doi:10.1073/pnas.1113888108. PMC 3198343. PMID 21987819. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198343/. 
  23. ^ Foran, P. G.; Mohammed, N.; Lisk, G. O.; Nagwaney, S.; Lawrence, G. W.; Johnson, E.; Smith, L.; Aoki, K. R. et al. (2002). “Evaluation of the Therapeutic Usefulness of Botulinum Neurotoxin B, C1, E, and F Compared with the Long Lasting Type A. BASIS FOR DISTINCT DURATIONS OF INHIBITION OF EXOCYTOSIS IN CENTRAL NEURONS”. Journal of Biological Chemistry 278 (2): 1363–1371. doi:10.1074/jbc.M209821200. PMID 12381720. 
  24. ^ a b Harata, N. C.; Aravanis, A. M.; Tsien, R. W. (2006). “Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion”. Journal of Neurochemistry 97 (6): 1546–1570. doi:10.1111/j.1471-4159.2006.03987.x. PMID 16805768. 
  25. ^ Alvarez De Toledo, G.; Alés, E.; Tabares, L. A.; Poyato, J. M.; Valero, V.; Lindau, M. (1999). “High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism”. Nature Cell Biology 1 (1): 40–44. doi:10.1038/9012. PMID 10559862. 
  26. ^ Zhang, Q.; Li, Y.; Tsien, R. W. (2009). “The Dynamic Control of Kiss-And-Run and Vesicular Reuse Probed with Single Nanoparticles”. Science 323 (5920): 1448–1453. Bibcode2009Sci...323.1448Z. doi:10.1126/science.1167373. PMC 2696197. PMID 19213879. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696197/. 
  27. ^ Palay, Sanford L.; Palade, George E. (1954). “Electron microscope study of the cytoplasm of neurons”. The Anatomical Record 118: 336. doi:10.1002/ar.1091180211. 
  28. ^ Eduardo D. P., De Robertis; Stanley, Bennett, H. (January 25, 1955). “Some Features of the Submicroscopic Morphology of Synapses in Frog and Earthworm”. The Journal of Biophysical and Biochemical Cytology 1 (1): 47–58. doi:10.1083/jcb.1.1.47. JSTOR 1602913. PMC 2223594. PMID 14381427. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223594/. 
  29. ^ “Submicroscopic vesicular component in the synapse”. Fed Proc 13: 35. (1954). 
  30. ^ Fatt, P.; Katz, B. (7 October 1950). “Some Observations on Biological Noise”. Nature 166 (4223): 597–598. Bibcode1950Natur.166..597F. doi:10.1038/166597a0. PMID 14780165. 
  31. ^ Fatt, P.; Katz, B. (May 28, 1952). “Spontaneous subthreshold activity at motor nerve endings”. The Journal of Physiology 117 (1): 109–128. doi:10.1113/jphysiol.1952.sp004735. PMC 1392564. PMID 14946732. http://204.71.142.23/skins/main/pdf/HistoryofNeuroscience/fatt2.pdf 2014年2月1日閲覧。. 
  32. ^ “Quantal components of the endplate potential”. J. Physiol. 124 (3): 560–573. (1954). doi:10.1113/jphysiol.1954.sp005129. PMC 1366292. PMID 13175199. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366292/. 
  33. ^ “Biophysical aspects of neuromuscular transmission”. Prog Biophys Biophys Chem 6: 121–170. (1954). PMID 13420190. 
  34. ^ “The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived from homogenization and centrifugation”. J Anat 96: 79–88. (1962). PMC 1244174. PMID 13901297. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1244174/. 
  35. ^ Zimmermann, Herbert (2018). “The discovery of the synaptosome and its implications.”. Neuromethods 141: 9–26. doi:10.1007/978-1-4939-8739-9_2. 
  36. ^ “The separation of synaptic vesicles from disrupted nerve ending particles”. Biochem Pharmacol 12 (2): 300–302. (1963). doi:10.1016/0006-2952(63)90156-4. PMID 14000416. 
  37. ^ “The separation of synaptic vesicles from nerve ending particles ('synaptosomes')”. Biochem J 90 (2): 293–303. (1964). doi:10.1042/bj0900293. PMC 1202615. PMID 5834239. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1202615/. 
  38. ^ “Isolation of synaptic vesicles and structural organization of the acetylcholine system within brain nerve endings”. J Neurochem 10 (4): 225–235. (1963). doi:10.1111/j.1471-4159.1963.tb05038.x. PMID 14026026. 
  39. ^ “The morphology and acetylcholine content of isolated cerebral cortical synaptic vesicles”. J Neurochem 12 (5): 363–372. (1965). doi:10.1111/j.1471-4159.1965.tb04237.x. PMID 14333293. 
  40. ^ “The isolation of cholinergic synaptic vesicles from bovine superior cervical ganglion and estimation of their acetylcholine content”. J Neurochem 20 (3): 659–667. (1973). doi:10.1111/j.1471-4159.1973.tb00026.x. PMID 4574192. 
  41. ^ Jones DG (1970). “The isolation of synaptic vesicles from Octopus brain”. Brain Res 17 (2): 181–193. doi:10.1016/0006-8993(70)90077-6. PMID 5412681. 
  42. ^ “Subcellular fractionation of the electric organ of Torpedo marmorata”. J Neurochem 17 (10): 1441–1450. (1970). doi:10.1111/j.1471-4159.1970.tb00511.x. PMID 5471906. 
  43. ^ “The isolation of pure cholinergic synaptic vesicles from the electric organs of elasmobranch fish of the family Torpidinidae”. Biochem J 128 (4): 833–846. (1972). doi:10.1042/bj1280833. PMC 1173903. PMID 4638794. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1173903/. 


「シナプス小胞」の続きの解説一覧




シナプス小胞と同じ種類の言葉

このページでは「ウィキペディア」からシナプス小胞を検索した結果を表示しています。
Weblioに収録されているすべての辞書からシナプス小胞を検索する場合は、下記のリンクをクリックしてください。
 全ての辞書からシナプス小胞 を検索

英和和英テキスト翻訳>> Weblio翻訳
英語⇒日本語日本語⇒英語
  

辞書ショートカット

すべての辞書の索引

「シナプス小胞」の関連用語

シナプス小胞のお隣キーワード
検索ランキング

   

英語⇒日本語
日本語⇒英語
   



シナプス小胞のページの著作権
Weblio 辞書 情報提供元は 参加元一覧 にて確認できます。

   
ウィキペディアウィキペディア
All text is available under the terms of the GNU Free Documentation License.
この記事は、ウィキペディアのシナプス小胞 (改訂履歴)の記事を複製、再配布したものにあたり、GNU Free Documentation Licenseというライセンスの下で提供されています。 Weblio辞書に掲載されているウィキペディアの記事も、全てGNU Free Documentation Licenseの元に提供されております。

©2024 GRAS Group, Inc.RSS