デスモグレイン
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/04/23 16:28 UTC 版)
疾患
デスモグレインの異常は接着斑の異常、つまり、上皮組織の異常になる。デスモグレインの変異または自己抗体が原因のヒト皮膚病を示す。
デスモグレイン | 皮膚病 |
---|---|
デスモグレイン1 | Striate palmoplantar keratoderma 落葉状天疱瘡(Pemphigus foliaceous)[6] Bullous impetigo 伝染性膿痂疹(でんせんせいのうかしん)(Staphylococcal scalded skin syndrome) ブラジル天疱瘡(Fogo selvagem) 紅斑性天疱瘡(Pemphigus erythematosus) 尋常性天疱瘡(Mucosal pemphigus vulgaris) |
デスモグレイン2 | 不整脈源性右室心筋症 (Arrhythmogenic right ventricular dysplasia、ARVD) |
デスモグレイン3 | 尋常性天疱瘡(Mucosal pemphigus vulgaris) 増殖性天疱瘡(Pemphigus vegetans) |
デスモグレイン4 | 遺伝性魚鱗癬(inherited ichthyosis)[7] 尋常性天疱瘡(pemphigus vulgaris)[7] Localized autosomal recessive hypotrichosis 連珠毛(れんじゅもう)(Autosomal recessive monilethrix) |
参考文献
- Amagai M, Stanley JR (Mar 2012). “Desmoglein as a target in skin disease and beyond”. J Invest Dermatol 132 (3 Pt 2): 776-784. doi:10.1038/jid.2011.390.. PMC 3279627. PMID 22189787 .(英語)
- AP Kowalczyk, KJ Green (1996). “Chapter10. The desmosome: a comparison system for adhesion and intermediate filament attachment”. In WJ Nelson. Membrane Protein-Cytoskeleton Interactions. Academic Press. p. 187-210. ISBN 012-153343-3(英語)
- Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002). “anchoring junction”. Molecular Biology of the Cell (4th ed.). New York: Garland Science. ISBN 0-8153-3218-1(英語)
関連項目
- デスモコリン(desmocollins)
- 接着斑(デスモソーム)
- 細胞接着分子
- 接着斑タンパク質が原因の皮膚病の一覧
- List of keratins expressed in the human integumentary system(英語)
- List of target antigens in pemphigus(英語)
- List of immunofluorescence findings for autoimmune bullous conditions(英語)
- List of cutaneous conditions(英語)
- List of genes mutated in cutaneous conditions(英語)
- List of histologic stains that aid in diagnosis of cutaneous conditions(英語)
- Keratoderma(英語)
- ^ Skerrow CJ, Matoltsy AG (1974). “Chemical characterization of isolated epidermal desmosomes”. J Cell Biol 63 (2 Pt 1): 524-530. PMC 2110930. PMID 4421013 .
- ^ Gorbsky G, Steinberg MS (July 1981). “Isolation of the intercellular glycoproteins of desmosomes”. J Cell Biol 90 (1): 243-248. PMC 2111822. PMID 6166625 .
- ^ Giudice GJ, Cohen SM, Patel NH, Steinberg MS (1984). “Immunological comparison of desmosomal components from several bovine tissues”. J Cell Biochem 26 (1): 35-45. PMID 6392310 .
- ^ Koch PJ, Walsh MJ, Schmelz M, Goldschmidt MD, Zimbelmann R, Franke WW (Oct 1990). “Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules”. Eur J Cell Biol 53 (1): 1-12. PMID 1706270.
- ^ Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, Steinberg MS (May 1993). “Nomenclature of the desmosomal cadherins”. J Cell Biol 121 (3): 481-483. PMC 2119574. PMID 8486729 .
- ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). “Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction”. J. Clin. Invest. 115 (11): 3157-3165. doi:10.1172/JCI23475. PMC 1242188. PMID 16211092 .
- ^ a b Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). “Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris”. Cell 113 (2): 249?60. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872 .
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