ヌクレオソーム
核内でDNA二重鎖を折りたたんでいるタンパク質複合体。DNAを物理的、化学的な損傷から守っている。
コアヒストンはH2Ax2, H2Bx2, H3x2, H4x2の8量体であり、この周りに146塩基1)のDNAが巻きつき、ヌクレオソームを形成する。ヌクレオソームあたり200塩基対のDNAが含まれ、粒径は約11nmである。
PDB entry
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ヌクレオソーム
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/07/03 09:58 UTC 版)
ヌクレオソーム(nucleosome)は、真核生物におけるDNAのパッケージングの基本的単位であり、クロマチンの基本要素である。ヌクレオソームは、ヒストン八量体 (histone octamer) とその周囲に巻きついたDNAから構成される[1]。ヒストン八量体はヒストンH2A、H2B、H3、H4各2コピーずつから成る。
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