RET (タンパク質)

ウィキペディア

索引トップランキングカテゴリー

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/10/04 05:15 UTC 版)

RET

PDBに登録されている構造

PDB

オルソログ検索: RCSB PDBe PDBj

PDBのIDコード一覧
2IVS, 2IVT, 2IVU, 2IVV, 2X2K, 2X2L, 2X2M, 2X2U, 4CKI, 4CKJ, 4UX8, 5AMN

識別子

記号

RET, Ret, PTC, RET51, RET9, c-Ret, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, RET-ELE1, ret proto-oncogene

外部ID

OMIM: 164761 MGI: 97902 HomoloGene: 7517 GeneCards: RET

遺伝子の位置 (ヒト)

染色体	10番染色体 (ヒト)^[1]

バンド	データ無し	開始点	43,077,064 bp^[1]
バンド	データ無し	終点	43,130,351 bp^[1]

遺伝子の位置 (マウス)

染色体	6番染色体 (マウス)^[2]

バンド	データ無し	開始点	118,128,706 bp^[2]
バンド	データ無し	終点	118,174,679 bp^[2]

RNA発現パターン

さらなる参照発現データ

遺伝子オントロジー
分子機能	• transferase activity • ヌクレオチド結合 • calcium ion binding • protein kinase activity • キナーゼ活性 • 血漿タンパク結合 • protein tyrosine kinase activity • ATP binding • シグナル伝達受容体活性 • transmembrane receptor protein tyrosine kinase activity • 受容体型チロシンキナーゼ • 膜貫通シグナル伝達受容体活性
細胞の構成要素	• integral component of membrane • エンドソーム • intracellular membrane-bounded organelle • 膜 • receptor complex • integral component of plasma membrane • 神経繊維 • neuronal cell body • 樹状突起 • early endosome • 脂質ラフト • endosome membrane • 細胞膜 • 細胞質基質 • plasma membrane protein complex • 細胞質
生物学的プロセス	• cellular response to retinoic acid • ureteric bud development • embryonic epithelial tube formation • membrane protein proteolysis • リン酸化 • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • neuron cell-cell adhesion • 神経系発生 • neuron maturation • positive regulation of metanephric glomerulus development • positive regulation of transcription, DNA-templated • regulation of axonogenesis • タンパク質リン酸化 • 腸管神経系発生 • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • regulation of cell adhesion • lymphocyte migration into lymphoid organs • 細胞接着 • positive regulation of gene expression • ureter maturation • response to pain • retina development in camera-type eye • neural crest cell migration • neuron differentiation • positive regulation of cell size • positive regulation of neuron projection development • posterior midgut development • positive regulation of cell adhesion mediated by integrin • 神経支配 • positive regulation of neuron maturation • activation of cysteine-type endopeptidase activity involved in apoptotic process • シグナル伝達 • homophilic cell adhesion via plasma membrane adhesion molecules • Peyer's patch morphogenesis • peptidyl-tyrosine phosphorylation • MAPK cascade • 軸索誘導 • positive regulation of peptidyl-serine phosphorylation of STAT protein • glial cell-derived neurotrophic factor receptor signaling pathway • positive regulation of MAPK cascade • positive regulation of protein kinase B signaling • negative regulation of signal transduction • 細胞分化 • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • 神経発生
出典:Amigo / QuickGO

オルソログ

種

ヒト

マウス

Entrez


5979


19713

Ensembl


ENSG00000165731


ENSMUSG00000030110

UniProt


P07949,A0A024R7T2,C9JYL6


P35546

RefSeq
(mRNA)


NM_000323 NM_020629 NM_020630 NM_020975 NM_001355216


NM_001080780 NM_009050

RefSeq
(タンパク質)


NP_065681 NP_066124 NP_001342145 NP_066124.1


NP_001074249 NP_033076

場所
(UCSC)

Chr 10: 43.08 – 43.13 Mb

Chr 10: 118.13 – 118.17 Mb

PubMed検索

^[3]

^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165731 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030110 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Structure and chemical inhibition of the RET tyrosine kinase domain”. J. Biol. Chem. 281 (44): 33577–87. (2006). doi:10.1074/jbc.M605604200. PMID 16928683.
^ Martucciello, G.; Ceccherini, I.; Lerone, M.; Jasonni, V. (2000-07). “Pathogenesis of Hirschsprung's disease”. Journal of Pediatric Surgery 35 (7): 1017–1025. doi:10.1053/jpsu.2000.7763. ISSN 0022-3468. PMID 10917288.
^ ^a ^b “RET germline mutations identified by exome sequencing in a Chinese multiple endocrine neoplasia type 2A/familial medullary thyroid carcinoma family”. PLoS ONE 6 (5): e20353. (2011). Bibcode: 2011PLoSO...620353Q. doi:10.1371/journal.pone.0020353. PMC 3105051. PMID 21655256.
^ “Activation of a novel human transforming gene, ret, by DNA rearrangement.”. Cell 42 (2): 581–8. (1985). doi:10.1016/0092-8674(85)90115-1. PMID 2992805.
^ “Exon structure and flanking intronic sequences of the human RET proto-oncogene”. Biochem. Biophys. Res. Commun. 196 (3): 1288–1295. (1993). doi:10.1006/bbrc.1993.2392. PMID 7902707.
^ “Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET”. Oncogene 11 (10): 2039–2045. (1995). PMID 7478523.
^ ^a ^b ^c “RET tyrosine kinase signaling in development and cancer”. Cytokine Growth Factor Rev. 16 (4–5): 441–67. (2005). doi:10.1016/j.cytogfr.2005.05.010. PMID 15982921.
^ “Characterization of the ret proto-oncogene products expressed in mouse L cells”. Oncogene 8 (11): 2925–2929. (1993). PMID 8414495.
^ “The GDNF family ligands and receptors - implications for neural development”. Curr. Opin. Neurobiol. 10 (1): 103–10. (2000). doi:10.1016/S0959-4388(99)00048-3. PMID 10679429.
^ “GDNF family neurotrophic factor signaling: four masters, one servant?”. Mol. Cell. Neurosci. 13 (5): 313–25. (1999). doi:10.1006/mcne.1999.0754. PMID 10356294.
^ “Identification of RET autophosphorylation sites by mass spectrometry”. J. Biol. Chem. 279 (14): 14213–24. (2004). doi:10.1074/jbc.M312600200. PMID 14711813.
^ Online 'Mendelian Inheritance in Man' (OMIM) MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A -171400
^ Menicali, Elisa; Moretti, Sonia; Voce, Pasquale; Romagnoli, Serena; Avenia, Nicola; Puxeddu, Efisio (2012). “Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma”. Frontiers in Endocrinology 3: 67. doi:10.3389/fendo.2012.00067. ISSN 1664-2392. PMC 3357465. PMID 22661970.
^ “Role of Dok1 in cell signaling mediated by RET tyrosine kinase”. J. Biol. Chem. 277 (36): 32781–90. (September 2002). doi:10.1074/jbc.M202336200. PMID 12087092.
^ “Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth”. J. Biol. Chem. 279 (40): 42072–81. (October 2004). doi:10.1074/jbc.M403726200. PMID 15286081.
^ “Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation”. J. Cell Biol. 154 (2): 345–54. (July 2001). doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
^ “A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor”. Nature 387 (6634): 717–21. (June 1997). doi:10.1038/42722. PMID 9192898.
^ “Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions”. J. Biol. Chem. 275 (36): 27505–12. (September 2000). doi:10.1074/jbc.M000306200. PMID 10829012.
^ ^a ^b “The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10”. J. Biol. Chem. 270 (37): 21461–3. (September 1995). doi:10.1074/jbc.270.37.21461. PMID 7665556.
^ “Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7”. J. Biol. Chem. 271 (18): 10607–10. (May 1996). doi:10.1074/jbc.271.18.10607. PMID 8631863.
^ ^a ^b “The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins”. Oncogene 9 (6): 1661–8. (June 1994). PMID 8183561.
^ “Identification of Shc docking site on Ret tyrosine kinase”. Oncogene 14 (7): 773–82. (February 1997). doi:10.1038/sj.onc.1200896. PMID 9047384.
^ “Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells”. Mol. Cell. Biol. 24 (21): 9390–400. (November 2004). doi:10.1128/MCB.24.21.9390-9400.2004. PMC 522220. PMID 15485908.
^ “Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation”. Mol. Endocrinol. 17 (6): 1155–66. (June 2003). doi:10.1210/me.2002-0401. PMID 12637586.
^ “MEN2A-RET-induced cellular transformation by activation of STAT3”. Oncogene 20 (38): 5350–8. (August 2001). doi:10.1038/sj.onc.1204715. PMID 11536047.

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