CTCF CTCFの概要

CTCF
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1X6H, 2CT1
識別子
記号	CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
外部ID	OMIM: 604167 MGI: 109447 HomoloGene: 4786 GeneCards: CTCF
遺伝子の位置 (ヒト)
染色体	16番染色体 (ヒト)
終点	67,639,177 bp
遺伝子の位置 (マウス)
染色体	8番染色体 (マウス)
終点	105,682,922 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • transcription corepressor activity; • DNA-binding transcription factor activity; • zinc ion binding; • 金属イオン結合; • chromatin insulator sequence binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription repressor activity, RNA polymerase II-specific; • 血漿タンパク結合; • 核酸結合; • DNA-binding transcription factor activity, RNA polymerase II-specific; • sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific; • クロマチン結合;
細胞の構成要素	• 核質; • 染色体; • 核小体; • セントロメア; • condensed chromosome; • 細胞核;
生物学的プロセス	• regulation of transcription, DNA-templated; • regulation of gene expression, epigenetic; • regulation of centromeric sister chromatid cohesion; • 染色体分離; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • negative regulation of transcription, DNA-templated; • protein localization to chromosome, centromeric region; • negative regulation of cell population proliferation; • chromatin organization; • negative regulation of transcription by RNA polymerase II; • positive regulation of gene expression; • DNAメチル化; • regulation of gene expression by genetic imprinting; • maintenance of DNA methylation; • 遺伝子発現の負の調節; • regulation of histone methylation; • regulation of histone acetylation; • positive regulation of transcription by RNA polymerase II;
	出典:Amigo / QuickGO
オルソログ
	10664
	13018
	ENSG00000102974
	ENSMUSG00000005698
	P49711
	Q61164
	NM_001191022; NM_006565; NM_001363916
	NM_181322; NM_001358924
	NP_001177951; NP_006556; NP_001350845
NP_851839; NP_001345853; NP_001390652; NP_001390653; NP_001390654;
	NP_001390655; NP_001390656; NP_001390657; NP_001390658; NP_001390659; NP_001390660; NP_001390661
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102974 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005698 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ ^a ^b “An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes”. Mol. Cell. Biol. 16 (6): 2802–13. (June 1996). PMC 231272. PMID 8649389.
^ “CTCF physically links cohesin to chromatin”. Proc. Natl. Acad. Sci. U.S.A. 105 (24): 8309–14. (June 2008). doi:10.1073/pnas.0801273105. PMC 2448833. PMID 18550811.
^ ^a ^b ^c “CTCF: master weaver of the genome”. Cell 137 (7): 1194–211. (June 2009). doi:10.1016/j.cell.2009.06.001. PMC 3040116. PMID 19563753.
^ “A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene”. Oncogene 5 (12): 1743–53. (December 1990). PMID 2284094.
^ ^a ^b “Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions”. Nature 453 (7197): 948–51. (June 2008). doi:10.1038/nature06947. PMID 18463634.
^ “CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease”. Trends Genet. 17 (9): 520–7. (2001). doi:10.1016/S0168-9525(01)02366-6. PMID 11525835.
^ “The many roles of the transcriptional regulator CTCF”. Biochem. Cell Biol. 81 (3): 161–7. (2003). doi:10.1139/o03-052. PMID 12897849.
^ ^a ^b ^c “Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains”. Genome Res. 19 (1): 24–32. (2009). doi:10.1101/gr.082800.108. PMC 2612964. PMID 19056695.
^ ^a ^b “CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species”. Mol. Cell 13 (2): 291–8. (January 2004). doi:10.1016/S1097-2765(04)00029-2. PMID 14759373.
^ “CTCF-dependent enhancer-blocking by alternative chromatin loop formation”. Proc. Natl. Acad. Sci. U.S.A. 105 (51): 20398–403. (December 2008). doi:10.1073/pnas.0808506106. PMC 2629272. PMID 19074263.
^ “Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation”. J. Biol. Chem. 287 (37): 30906–13. (September 2012). doi:10.1074/jbc.R111.324962. PMC 3438923. PMID 22952237.
^ “CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing”. Nature 479 (7371): 74–9. (November 2011). doi:10.1038/nature10442. PMID 21964334.
^ ^a ^b “Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome”. Cell 128 (6): 1231–45. (March 2007). doi:10.1016/j.cell.2006.12.048. PMC 2572726. PMID 17382889.
^ ^a ^b “Methylation loss at H19 imprinted gene correlates with methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples from infertile males”. Epigenetics 9 (9): 990–7. (September 2013). doi:10.4161/epi.25798. PMC 3883776. PMID 23975186.
^ “Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene”. Nature 405 (6785): 482–5. (May 2000). doi:10.1038/35013100. PMID 10839546.
^ “Widespread plasticity in CTCF occupancy linked to DNA methylation”. Genome Res. 22 (9): 1680–8. (September 2012). doi:10.1101/gr.136101.111. PMC 3431485. PMID 22955980.
^ “CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators”. Nucleic Acids Res. 36 (Database issue): D83–7. (January 2008). doi:10.1093/nar/gkm875. PMC 2238977. PMID 17981843.
^ “Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites”. Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7145–50. (2007). doi:10.1073/pnas.0701811104. PMC 1852749. PMID 17442748.
^ “The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome”. PLOS Genetics 4 (7): e1000138. (2008). doi:10.1371/journal.pgen.1000138. PMC 2453330. PMID 18654629.
^ “Genome-wide nucleosome positioning during embryonic stem cell development”. Nat Struct Mol Biol 19 (11): 1185–92. (2012). doi:10.1038/nsmb.2419. PMID 23085715.
^ “Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF”. J. Biol. Chem. 275 (38): 29915–21. (September 2000). doi:10.1074/jbc.M001538200. PMID 10906122.
^ “Mediator and cohesin connect gene expression and chromatin architecture”. Nature 467 (7314): 430–5. (September 2010). doi:10.1038/nature09380. PMC 2953795. PMID 20720539.

[前の解説]

[続きの解説]

「CTCF」の続きの解説一覧

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102974 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005698 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid8649389-5] “An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes”. Mol. Cell. Biol. 16 (6): 2802–13. (June 1996). PMC 231272. PMID 8649389.

[pmid18550811-6] “CTCF physically links cohesin to chromatin”. Proc. Natl. Acad. Sci. U.S.A. 105 (24): 8309–14. (June 2008). doi:10.1073/pnas.0801273105. PMC 2448833. PMID 18550811.

[Phillips_Corces_2009-7] “CTCF: master weaver of the genome”. Cell 137 (7): 1194–211. (June 2009). doi:10.1016/j.cell.2009.06.001. PMC 3040116. PMID 19563753.

[pmid2284094-8] “A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene”. Oncogene 5 (12): 1743–53. (December 1990). PMID 2284094.

[Guelen_2008-9] “Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions”. Nature 453 (7197): 948–51. (June 2008). doi:10.1038/nature06947. PMID 18463634.

[pmid11525835-10] “CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease”. Trends Genet. 17 (9): 520–7. (2001). doi:10.1016/S0168-9525(01)02366-6. PMID 11525835.

[pmid12897849-11] “The many roles of the transcriptional regulator CTCF”. Biochem. Cell Biol. 81 (3): 161–7. (2003). doi:10.1139/o03-052. PMID 12897849.

[pmid19056695-12] “Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains”. Genome Res. 19 (1): 24–32. (2009). doi:10.1101/gr.082800.108. PMC 2612964. PMID 19056695.

[Yusufzai_2004-13] “CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species”. Mol. Cell 13 (2): 291–8. (January 2004). doi:10.1016/S1097-2765(04)00029-2. PMID 14759373.

[pmid19074263-14] “CTCF-dependent enhancer-blocking by alternative chromatin loop formation”. Proc. Natl. Acad. Sci. U.S.A. 105 (51): 20398–403. (December 2008). doi:10.1073/pnas.0808506106. PMC 2629272. PMID 19074263.

[pmid22952237-15] “Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation”. J. Biol. Chem. 287 (37): 30906–13. (September 2012). doi:10.1074/jbc.R111.324962. PMC 3438923. PMID 22952237.

[pmid21964334-16] “CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing”. Nature 479 (7371): 74–9. (November 2011). doi:10.1038/nature10442. PMID 21964334.

[pmid17382889-17] “Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome”. Cell 128 (6): 1231–45. (March 2007). doi:10.1016/j.cell.2006.12.048. PMC 2572726. PMID 17382889.

[Rotondo_2013-18] “Methylation loss at H19 imprinted gene correlates with methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples from infertile males”. Epigenetics 9 (9): 990–7. (September 2013). doi:10.4161/epi.25798. PMC 3883776. PMID 23975186.

[pmid10839546-19] “Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene”. Nature 405 (6785): 482–5. (May 2000). doi:10.1038/35013100. PMID 10839546.

[pmid22955980-20] “Widespread plasticity in CTCF occupancy linked to DNA methylation”. Genome Res. 22 (9): 1680–8. (September 2012). doi:10.1101/gr.136101.111. PMC 3431485. PMID 22955980.

[pmid17981843-21] “CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators”. Nucleic Acids Res. 36 (Database issue): D83–7. (January 2008). doi:10.1093/nar/gkm875. PMC 2238977. PMID 17981843.

[pmid17442748-22] “Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites”. Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7145–50. (2007). doi:10.1073/pnas.0701811104. PMC 1852749. PMID 17442748.

[pmid18654629-23] “The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome”. PLOS Genetics 4 (7): e1000138. (2008). doi:10.1371/journal.pgen.1000138. PMC 2453330. PMID 18654629.

[Teif-24] “Genome-wide nucleosome positioning during embryonic stem cell development”. Nat Struct Mol Biol 19 (11): 1185–92. (2012). doi:10.1038/nsmb.2419. PMID 23085715.

[pmid10906122-25] “Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF”. J. Biol. Chem. 275 (38): 29915–21. (September 2000). doi:10.1074/jbc.M001538200. PMID 10906122.

[pmid20720539-26] “Mediator and cohesin connect gene expression and chromatin architecture”. Nature 467 (7314): 430–5. (September 2010). doi:10.1038/nature09380. PMC 2953795. PMID 20720539.

[1]

[2]

[3]

[4]

CTCF CTCFの概要

CTCF

急上昇のことば

「CTCF」の関連用語