タウオパチー
タウオパチー
(tauopathy から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/04/25 09:03 UTC 版)
タウオパチー（英: tauopathy）は、ヒトの脳の神経細胞やグリア細胞において、タウタンパク質による神経原線維変化（neurofibrillary tangle、NFT）やglial fibrillary tangleの形成を伴う神経変性疾患群である。タウと呼ばれる微小管結合タンパク質の過剰なリン酸化によって生じ、その結果タウは微小管から解離し不溶性の凝集体を形成する[1]。こうした凝集体は対らせん状細線維（paired helical filament）とも呼ばれる。凝集の形成過程はあまり解明されておらず、それらがアルツハイマー病の主要因であるのか、それとも補助的役割を果たしているだけであるのかについても明らかではない。
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[続きの解説]
「タウオパチー」の続きの解説一覧
- 1 タウオパチーとは
- 2 タウオパチーの概要
- 3 関連項目
- tauopathyのページへのリンク
