APC (タンパク質)
(adenomatous polyposis coli から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/05/12 08:45 UTC 版)
APC（adenomatous polyposis coli）は、ヒトではAPC遺伝子によってコードされるタンパク質である[4]。DP2.5（deleted in polyposis 2.5）としても知られる。APCタンパク質はβ-カテニンの濃度を負に制御する調節因子であり、細胞接着に関与するE-カドヘリンと相互作用する。APC遺伝子の変異は大腸がんにつながる可能性がある[5]。
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005871 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients”. Science 253 (5020): 665–9. (August 1991). Bibcode: 1991Sci...253..665N. doi:10.1126/science.1651563. PMID 1651563.
- ^ a b “Molecular origins of cancer: Molecular basis of colorectal cancer”. The New England Journal of Medicine 361 (25): 2449–60. (December 2009). doi:10.1056/NEJMra0804588. PMC 2843693. PMID 20018966.
- ^ “The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853 (3): 711–23. (March 2015). doi:10.1016/j.bbamcr.2014.12.036. PMC 4327896. PMID 25578398.
- ^ a b “Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?”. Molecular Cancer 10: 101. (2011). doi:10.1186/1476-4598-10-101. PMC 3170638. PMID 21859464.
- ^ “Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations”. PLOS ONE 8 (10): e77257. (2013). Bibcode: 2013PLoSO...877257M. doi:10.1371/journal.pone.0077257. PMC 3793970. PMID 24130866.
- ^ Laurent-Puig, P.; Béroud, C.; Soussi, T. (1998-01-01). “APC gene: database of germline and somatic mutations in human tumors and cell lines”. Nucleic Acids Research 26 (1): 269–270. doi:10.1093/nar/26.1.269. ISSN 0305-1048. PMC PMC147178. PMID 9399850.
- ^ Moisio, A.-L.; Järvinen, H.; Peltomäki, P. (2002-06). “Genetic and clinical characterisation of familial adenomatous polyposis: a population based study”. Gut 50 (6): 845–850. doi:10.1136/gut.50.6.845. ISSN 0017-5749. PMC 1773245. PMID 12010888.
- ^ Caspari, R.; Friedl, W.; Mandl, M.; Möslein, G.; Kadmon, M.; Knapp, M.; Jacobasch, K. H.; Ecker, K. W. et al. (1994-03-12). “Familial adenomatous polyposis: mutation at codon 1309 and early onset of colon cancer”. Lancet (London, England) 343 (8898): 629–632. doi:10.1016/s0140-6736(94)92634-4. ISSN 0140-6736. PMID 7906810.
- ^ “Familial Adenomatous Polyposis” (英語). stanfordhealthcare.org. 2020年10月11日閲覧。
- ^ Kimelman, D.; Xu, W. (2006-12-04). “beta-catenin destruction complex: insights and questions from a structural perspective”. Oncogene 25 (57): 7482–7491. doi:10.1038/sj.onc.1210055. ISSN 0950-9232. PMID 17143292.
- ^ Leber, M. F., Efferth, T."Molecular principles of cancer invasion and metastasis (Review)". International Journal of Oncology 34, no. 4 (2009): 881-895. https://doi.org/10.3892/ijo_00000214
- ^ Rao, Tata Purushothama; Kühl, Michael (2010-06-25). “An updated overview on Wnt signaling pathways: a prelude for more”. Circulation Research 106 (12): 1798–1806. doi:10.1161/CIRCRESAHA.110.219840. ISSN 1524-4571. PMID 20576942.
- ^ Dikovskaya, D.; Zumbrunn, J.; Penman, G. A.; Näthke, I. S. (2001-09). “The adenomatous polyposis coli protein: in the limelight out at the edge”. Trends in Cell Biology 11 (9): 378–384. doi:10.1016/s0962-8924(01)02069-4. ISSN 0962-8924. PMID 11514192.
- ^ “The β-catenin destruction complex”. Cold Spring Harbor Perspectives in Biology 5 (1): a007898. (January 2013). doi:10.1101/cshperspect.a007898. PMC 3579403. PMID 23169527.
- ^ “Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling”. Genetics 197 (4): 1285–302. (August 2014). doi:10.1534/genetics.114.166496. PMC 4125400. PMID 24931405.
- ^ De Queiroz Rossanese, Lillian Barbosa; De Lima Marson, Fernando Augusto; Ribeiro, José Dirceu; Coy, Claudio Saddy Rodrigues; Bertuzzo, Carmen Silvia (2013-11). “APC germline mutations in families with familial adenomatous polyposis”. Oncology Reports 30 (5): 2081–2088. doi:10.3892/or.2013.2681. ISSN 1791-2431. PMID 23970361.
- ^ Fearnhead, N. S.; Britton, M. P.; Bodmer, W. F. (2001-04). “The ABC of APC”. Human Molecular Genetics 10 (7): 721–733. doi:10.1093/hmg/10.7.721. ISSN 0964-6906. PMID 11257105.
- ^ a b “The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo” (英語). The Journal of Neuroscience 30 (33): 11073–85. (August 2010). doi:10.1523/JNEUROSCI.0983-10.2010. PMC 2945243. PMID 20720115.
- ^ Zhou, Xiao-Lei; Giacobini, MaiBritt; Anderlid, Britt-Marie; Anckarsäter, Henrik; Omrani, Davood; Gillberg, Christopher; Nordenskjöld, Magnus; Lindblom, Annika (2007-04-05). “Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD)”. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics 144B (3): 351–354. doi:10.1002/ajmg.b.30415. ISSN 1552-4841. PMID 17221838.
- ^ “Asef, a link between the tumor suppressor APC and G-protein signaling”. Science 289 (5482): 1194–7. (August 2000). Bibcode: 2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.
- ^ “Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level”. Genes to Cells 3 (6): 395–403. (June 1998). doi:10.1046/j.1365-2443.1998.00198.x. PMID 9734785.
- ^ “A role for the Adenomatous Polyposis Coli protein in chromosome segregation”. Nature Cell Biology 3 (4): 429–32. (April 2001). doi:10.1038/35070123. PMID 11283619.
- ^ a b “Association of the APC tumor suppressor protein with catenins”. Science 262 (5140): 1734–7. (December 1993). Bibcode: 1993Sci...262.1734S. doi:10.1126/science.8259519. PMID 8259519.
- ^ “Expression and interaction of different catenins in colorectal carcinoma cells”. International Journal of Molecular Medicine 8 (6): 695–8. (December 2001). doi:10.3892/ijmm.8.6.695. PMID 11712088.
- ^ “Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein”. Journal of Molecular Biology 327 (2): 359–67. (March 2003). doi:10.1016/S0022-2836(03)00144-X. PMID 12628243.
- ^ “The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer”. International Journal of Oncology 18 (4): 843–7. (April 2001). doi:10.3892/ijo.18.4.843. PMID 11251183.
- ^ “Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC”. Nature Cell Biology 3 (9): 793–801. (September 2001). doi:10.1038/ncb0901-793. PMID 11533658.
- ^ a b c “Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein”. Proceedings of the National Academy of Sciences of the United States of America 99 (9): 5959–64. (April 2002). Bibcode: 2002PNAS...99.5959K. doi:10.1073/pnas.092143199. PMC 122884. PMID 11972058.
- ^ “DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95”. Genes to Cells 2 (6): 415–24. (June 1997). doi:10.1046/j.1365-2443.1997.1310329.x. PMID 9286858.
- ^ “Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex”. The EMBO Journal 20 (22): 6203–12. (November 2001). doi:10.1093/emboj/20.22.6203. PMC 125720. PMID 11707392.
- ^ a b “The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin”. Molecular and Cellular Biology 15 (9): 4819–24. (September 1995). doi:10.1128/mcb.15.9.4819. PMC 230726. PMID 7651399.
- ^ “Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein”. Oncogene 14 (20): 2425–33. (May 1997). doi:10.1038/sj.onc.1201087. PMID 9188857.
- ^ “Identification of a link between the tumour suppressor APC and the kinesin superfamily”. Nature Cell Biology 4 (4): 323–7. (April 2002). doi:10.1038/ncb779. PMID 11912492.
- ^ “APC binds to the novel protein EB1”. Cancer Research 55 (14): 2972–7. (July 1995). PMID 7606712.
- ^ “Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization”. Current Biology 11 (13): 1062–7. (July 2001). doi:10.1016/S0960-9822(01)00297-4. PMID 11470413.
- ^ “Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation”. Biochemical and Biophysical Research Communications 203 (1): 519–22. (August 1994). doi:10.1006/bbrc.1994.2213. PMID 8074697.
- ^ “Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein”. Molecular Cell 7 (5): 927–36. (May 2001). doi:10.1016/S1097-2765(01)00241-6. PMID 11389840.
- ^ “Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells”. The Journal of Biological Chemistry 279 (44): 45669–75. (October 2004). doi:10.1074/jbc.M405025200. PMC 2276578. PMID 15331612.
- ^ “Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation”. Current Biology 11 (1): 44–9. (January 2001). doi:10.1016/S0960-9822(01)00002-1. PMID 11166179.
- ^ “The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)”. The Journal of Biological Chemistry 277 (35): 32332–8. (August 2002). doi:10.1074/jbc.M203990200. PMID 12070164.
[続きの解説]
「APC (タンパク質)」の続きの解説一覧
- 1 APC (タンパク質)とは
- 2 APC (タンパク質)の概要
- 3 構造
- 4 変異
- 5 関連文献
- 6 関連項目
- APC (タンパク質)のページへのリンク
