TGF-β
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/03/26 13:41 UTC 版)
TGF-β(英: transforming growth factor β、トランスフォーミング増殖因子β、形質転換増殖因子β)は、TGF-βスーパーファミリーに属するサイトカインであり、多くの機能を有する。TGF-βファミリーにはTGF-βの3つのアイソフォーム(TGF-β1から3、ヒトではそれぞれTGFB1、TGFB2、TGFB3遺伝子にコードされる)や他の多くのシグナル伝達タンパク質が含まれる。TGF-βは全ての白血球系統の細胞で産生される。
- ^ a b “TGFβ signalling in context”. Nature Reviews. Molecular Cell Biology 13 (10): 616–30. (October 2012). doi:10.1038/nrm3434. PMC 4027049. PMID 22992590 .
- ^ “Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling”. Nature 389 (6651): 631–5. (October 1997). doi:10.1038/39369. PMID 9335507.
- ^ “AfCS signaling gateway - data center - ligand description”. www.signaling-gateway.org. 2021年3月13日閲覧。
- ^ a b “Regulation of immune responses by TGF-beta”. Annual Review of Immunology 16 (1): 137–61. (April 1998). doi:10.1146/annurev.immunol.16.1.137. PMID 9597127 .
- ^ “TGF-β control of stem cell differentiation genes”. FEBS Letters 586 (14): 1953–8. (July 2012). doi:10.1016/j.febslet.2012.03.023. PMC 3466472. PMID 22710171 .
- ^ “TGF-beta: a master of all T cell trades”. Cell 134 (3): 392–404. (August 2008). doi:10.1016/j.cell.2008.07.025. PMC 3677783. PMID 18692464 .
- ^ “TGFbeta signaling in growth control, cancer, and heritable disorders”. Cell 103 (2): 295–309. (October 2000). doi:10.1016/S0092-8674(00)00121-5. PMID 11057902.
- ^ Lichtman, Michael K.; Otero-Vinas, Marta; Falanga, Vincent (2016-03). “Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis”. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 24 (2): 215–222. doi:10.1111/wrr.12398. ISSN 1524-475X. PMID 26704519 .
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 190180
- ^ “TGFB1 - Transforming growth factor beta-1 proprotein precursor - Homo sapiens (Human) - TGFB1 gene & protein” (英語). www.uniprot.org. 2021年3月20日閲覧。
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 190220
- ^ “TGFB2 - Transforming growth factor beta-2 proprotein precursor - Homo sapiens (Human) - TGFB2 gene & protein” (英語). www.uniprot.org. 2021年3月20日閲覧。
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 190230
- ^ “TGFB3 - Transforming growth factor beta-3 proprotein precursor - Homo sapiens (Human) - TGFB3 gene & protein” (英語). www.uniprot.org. 2021年3月20日閲覧。
- ^ “Multiple forms of TGF-beta: distinct promoters and differential expression”. Ciba Foundation Symposium. Novartis Foundation Symposia 157: 7–15; discussion 15–28. (1991). doi:10.1002/9780470514061.ch2. ISBN 9780470514061. PMID 1906395.
- ^ “TGF-beta: from latent to active”. Microbes and Infection 1 (15): 1255–63. (December 1999). doi:10.1016/S1286-4579(99)00259-2. PMID 10611753.
- ^ “Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans”. Developmental and Comparative Immunology 28 (5): 461–85. (May 2004). doi:10.1016/j.dci.2003.09.007. PMID 15062644.
- ^ “Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily”. Science 257 (5068): 369–73. (July 1992). doi:10.1126/science.1631557. PMID 1631557 .
- ^ “Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells”. Nature 316 (6030): 701–5. (1985). doi:10.1038/316701a0. PMID 3861940 .
- ^ “Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability”. The Journal of Biological Chemistry 280 (9): 7409–12. (March 2005). doi:10.1074/jbc.R400029200. PMID 15611103.
- ^ “Processing of transforming growth factor beta 1 precursor by human furin convertase”. The Journal of Biological Chemistry 270 (18): 10618–24. (May 1995). doi:10.1074/jbc.270.18.10618. PMID 7737999.
- ^ a b c d e “Making sense of latent TGFbeta activation”. Journal of Cell Science 116 (Pt 2): 217–24. (January 2003). doi:10.1242/jcs.00229. PMID 12482908.
- ^ “Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action”. Cytokine & Growth Factor Reviews 10 (2): 99–117. (June 1999). doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
- ^ “Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer”. Genes & Development 16 (17): 2264–73. (September 2002). doi:10.1101/gad.229102. PMC 186672. PMID 12208849 .
- ^ “Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta”. Molecular Biology of the Cell 11 (8): 2691–704. (August 2000). doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463 .
- ^ “New insights into TGF-beta-Smad signalling”. Trends in Biochemical Sciences 29 (5): 265–73. (May 2004). doi:10.1016/j.tibs.2004.03.008. PMID 15130563.
- ^ a b “Tumor cell interactions with the extracellular matrix during invasion and metastasis”. Annual Review of Cell Biology 9: 541–73. (1993). doi:10.1146/annurev.cb.09.110193.002545. PMID 8280471 .
- ^ a b “Redox-mediated activation of latent transforming growth factor-beta 1”. Molecular Endocrinology 10 (9): 1077–83. (September 1996). doi:10.1210/me.10.9.1077. PMID 8885242 .
- ^ a b c “Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship”. European Journal of Cell Biology 87 (8-9): 601–15. (September 2008). doi:10.1016/j.ejcb.2008.01.012. PMID 18342983.
- ^ a b “Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis”. Genes & Development 14 (2): 163–76. (January 2000). PMC 316345. PMID 10652271 .
- ^ a b “Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein”. The Journal of Cell Biology 124 (1-2): 171–81. (January 1994). doi:10.1083/jcb.124.1.171. PMC 2119892. PMID 8294500 .
- ^ “Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium”. The Journal of Cell Biology 106 (5): 1659–65. (May 1988). doi:10.1083/jcb.106.5.1659. PMC 2115066. PMID 2967299 .
- ^ “Thrombospondin in clinical disease states”. Seminars in Thrombosis and Hemostasis 13 (3): 298–306. (July 1987). doi:10.1055/s-2007-1003505. PMID 3317840.
- ^ “Thrombospondin in early human wound tissue”. The Journal of Investigative Dermatology 89 (6): 551–4. (December 1987). doi:10.1111/1523-1747.ep12461198. PMID 3680981.
- ^ “Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism”. The Journal of Cell Biology 122 (4): 923–32. (August 1993). doi:10.1083/jcb.122.4.923. PMC 2119591. PMID 8349738 .
- ^ “Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology”. Cytokine & Growth Factor Reviews 11 (1-2): 59–69. (2000). doi:10.1016/S1359-6101(99)00029-5. PMID 10708953.
- ^ “Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin”. The Journal of Cell Biology 133 (4): 921–8. (May 1996). doi:10.1083/jcb.133.4.921. PMC 2120829. PMID 8666675 .
- ^ “Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins”. Cell 95 (4): 507–19. (November 1998). doi:10.1016/S0092-8674(00)81618-9. PMID 9827803.
- ^ “Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease”. Nature 359 (6397): 693–9. (October 1992). doi:10.1038/359693a0. PMC 3889166. PMID 1436033 .
- ^ “Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1”. Molecular Biology of the Cell 9 (9): 2627–38. (September 1998). doi:10.1091/mbc.9.9.2627. PMC 25536. PMID 9725916 .
- ^ a b “The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis”. Cell 96 (3): 319–28. (February 1999). doi:10.1016/S0092-8674(00)80545-0. PMID 10025398.
- ^ “Review of the activation of TGF-beta in immunity”. Journal of Leukocyte Biology 85 (1): 29–33. (January 2009). doi:10.1189/jlb.0708415. PMC 3188956. PMID 18818372 .
- ^ “The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1”. The Journal of Cell Biology 157 (3): 493–507. (April 2002). doi:10.1083/jcb.200109100. PMC 2173277. PMID 11970960 .
- ^ “Smads: transcriptional activators of TGF-beta responses” (英語). Cell 95 (6): 737–40. (December 1998). doi:10.1016/S0092-8674(00)81696-7. PMID 9865691.
- ^ “Smad-dependent and Smad-independent pathways in TGF-beta family signalling”. Nature 425 (6958): 577–84. (October 2003). doi:10.1038/nature02006. PMID 14534577.
- ^ “TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia”. Oncogene 24 (37): 5701–12. (August 2005). doi:10.1038/sj.onc.1208922. PMID 16123803.
- ^ “Non-Smad Signaling Pathways of the TGF-β Family”. Cold Spring Harbor Perspectives in Biology 9 (2). (February 2017). doi:10.1101/cshperspect.a022129. PMC 5287080. PMID 27864313 .
- ^ “ERK1/2 MAP kinases: structure, function, and regulation”. Pharmacological Research 66 (2): 105–43. (August 2012). doi:10.1016/j.phrs.2012.04.005. PMID 22569528.
- ^ “Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation”. Scientific Reports 5: 12300. (July 2015). doi:10.1038/srep12300. PMC 4507259. PMID 26189595 .
- ^ “Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death”. Proceedings of the National Academy of Sciences of the United States of America 90 (2): 770–4. (January 1993). doi:10.1073/pnas.90.2.770. PMC 45747. PMID 8421714 .
- ^ “Daxx, a novel Fas-binding protein that activates JNK and apoptosis” (英語). Cell 89 (7): 1067–76. (June 1997). doi:10.1016/S0092-8674(00)80294-9. PMC 2989411. PMID 9215629 .
- ^ “TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation”. Nature Cell Biology 3 (8): 708–14. (August 2001). doi:10.1038/35087019. PMID 11483955.
- ^ “HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells”. Cancer Research 63 (23): 8271–7. (December 2003). PMID 14678985.
- ^ a b “The T(reg)/Th17 cell balance: a new paradigm for autoimmunity”. Pediatric Research 65 (5 Pt 2): 26R-31R. (May 2009). doi:10.1203/PDR.0b013e31819e76c7. PMID 19218879.
- ^ “TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23”. Biochemical and Biophysical Research Communications 386 (1): 105–10. (August 2009). doi:10.1016/j.bbrc.2009.05.140. PMID 19501566.
- ^ a b “TGF-beta: a master of all T cell trades” (英語). Cell 134 (3): 392–404. (August 2008). doi:10.1016/j.cell.2008.07.025. PMC 3677783. PMID 18692464 .
- ^ “The dual nature of T(H)17 cells: shifting the focus to function”. Nature Immunology 11 (6): 471–6. (June 2010). doi:10.1038/ni.1882. PMID 20485275.
- ^ a b “Transforming growth factor-beta regulation of immune responses”. Annual Review of Immunology 24 (1): 99–146. (2006-01-01). doi:10.1146/annurev.immunol.24.021605.090737. PMID 16551245.
- ^ “Redirection of B cell responsiveness by transforming growth factor beta receptor”. Proceedings of the National Academy of Sciences of the United States of America 100 (12): 7241–6. (June 2003). doi:10.1073/pnas.0731875100. PMC 165860. PMID 12773615 .
- ^ “Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis”. The Journal of Biological Chemistry 275 (49): 38363–70. (December 2000). doi:10.1074/jbc.M004861200. PMID 10995749.
- ^ “TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha” (英語). Immunity 5 (1): 31–40. (July 1996). doi:10.1016/S1074-7613(00)80307-6. PMID 8758892.
- ^ “TGF-β - an excellent servant but a bad master” (英語). Journal of Translational Medicine 10 (1): 183. (September 2012). doi:10.1186/1479-5876-10-183. PMC 3494542. PMID 22943793 .
- ^ “Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity”. The Journal of Clinical Investigation 115 (1): 66–75. (January 2005). doi:10.1172/JCI19229. PMC 539188. PMID 15630445 .
- ^ “Transforming growth factor-beta: innately bipolar”. Current Opinion in Immunology 19 (1): 55–62. (February 2007). doi:10.1016/j.coi.2006.11.008. PMID 17137775 .
- ^ a b “Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis”. Science 332 (6026): 243–7. (April 2011). doi:10.1126/science.1201475. PMC 3144160. PMID 21436399 .
- ^ a b “The hallmarks of cancer”. Cell 100 (1): 57–70. (January 2000). doi:10.1016/S0092-8674(00)81683-9. PMID 10647931.
- ^ “Role of transforming growth factor beta in human disease”. The New England Journal of Medicine 342 (18): 1350–8. (May 2000). doi:10.1056/NEJM200005043421807. PMID 10793168.
- ^ “Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment”. Cytokine & Growth Factor Reviews 26 (4): 389–403. (August 2015). doi:10.1016/j.cytogfr.2015.06.001. PMC 4526340. PMID 26119834 .
- ^ Understanding Heart Disease: Research Explains Link Between Cholesterol and Heart Disease Archived 2007-11-12 at the Wayback Machine.
- ^ Entrez Gene (2007年). “TGFBR2 transforming growth factor, beta receptor II” (Entrez gene entry). 2007年1月11日閲覧。
- ^ “Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome”. Science 312 (5770): 117–21. (April 2006). doi:10.1126/science.1124287. PMC 1482474. PMID 16601194 .
- ^ “The molecular genetics of Marfan syndrome and related disorders”. Journal of Medical Genetics 43 (10): 769–87. (October 2006). doi:10.1136/jmg.2005.039669. PMC 2563177. PMID 16571647 .
- ^ “Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance”. Journal of Immunology 180 (5): 2830–8. (March 2008). doi:10.4049/jimmunol.180.5.2830. PMID 18292504.
- ^ a b “The neuroprotective functions of transforming growth factor beta proteins”. International Journal of Molecular Sciences 13 (7): 8219–58. (July 2012). doi:10.3390/ijms13078219. PMC 3430231. PMID 22942700 .
- ^ Nakahara, Jin; Maeda, Michiko; Aiso, Sadakazu; Suzuki, Norihiro (2012-02). “Current concepts in multiple sclerosis: autoimmunity versus oligodendrogliopathy”. Clinical Reviews in Allergy & Immunology 42 (1): 26–34. doi:10.1007/s12016-011-8287-6. ISSN 1559-0267. PMID 22189514 .
- ^ “A meta-analysis of cytokines in Alzheimer's disease”. Biological Psychiatry 68 (10): 930–41. (November 2010). doi:10.1016/j.biopsych.2010.06.012. PMID 20692646.
- ^ “Transforming growth factor-β signaling pathway activation in Keratoconus”. American Journal of Ophthalmology 151 (5): 752–759.e2. (May 2011). doi:10.1016/j.ajo.2010.11.008. PMC 3079764. PMID 21310385 .
- ^ “A systematic review of the importance of milk TGF-beta on immunological outcomes in the infant and young child”. Pediatric Allergy and Immunology 21 (1 Pt 1): 47–59. (February 2010). doi:10.1111/j.1399-3038.2009.00913.x. PMID 19594862.
- ^ Galindo, Yadira (26 December 2018). "UC San Diego Researchers Identify How Skin Ages, Loses Fat and Immunity" (Press release). University of California San Diego.
- ^ “Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta”. Immunity 50 (1): 121–136.e5. (January 2019). doi:10.1016/j.immuni.2018.11.003. PMC 7191997. PMID 30594464 .
- TGF-βのページへのリンク