ヘパリン結合性上皮増殖因子様増殖因子
同義/類義語：ヘパリン結合性EGF様増殖因子
英訳・(英)同義/類義語：HB-EGF, heparin-binding EGF-like growth factor
ヘパリン結合性を持つ上皮細胞増殖因子の総称。
英訳・(英)同義/類義語：HB-EGF, heparin-binding EGF-like growth factor
ヘパリン結合性を持つ上皮細胞増殖因子の総称。
「生物学用語辞典」の他の用語
| 酵素タンパク質モチーフなど： | プロテインキナーゼA プロトンATPアーゼ プロトンカリウムATPアーゼ ヘパリン結合性上皮増殖因子様増殖因子 ヘパリン結合性増殖因子 ヘモグロビン ベータアドレナリン受容体 |
HB-EGF【HB-EGF】
HB-EGF
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/17 13:47 UTC 版)
HB-EGF（heparin-binding EGF-like growth factor）は、ヒトではHBEGF遺伝子にコードされる、EGFファミリーのタンパク質である。ヘパリン結合性EGF様増殖因子などと訳されることもある[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000113070 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024486 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “循環器用語ハンドブック（WEB版） HB-EGF | 医療関係者向け情報 トーアエイヨー”. med.toaeiyo.co.jp. 2023年8月17日閲覧。
- ^ “Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor”. Cytokine Growth Factor Rev. 15 (1): 13–9. (February 2004). doi:10.1016/j.cytogfr.2003.10.002. PMID 14746810.
- ^ a b “Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo”. J. Neurosci. 22 (13): 5365–73. (July 2002). doi:10.1523/JNEUROSCI.22-13-05365.2002. PMC 6758221. PMID 12097488.
- ^ “Heparin-binding EGF-like growth factor”. Biochim. Biophys. Acta 1333 (3): F179–99. (December 1997). doi:10.1016/S0304-419X(97)00024-3. PMID 9426203.
- ^ “Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation”. Development 120 (5): 1071–83. (May 1994). doi:10.1242/dev.120.5.1071. PMID 8026321.
- ^ “N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration”. EMBO J. 20 (13): 3342–50. (July 2001). doi:10.1093/emboj/20.13.3342. PMC 125525. PMID 11432822.
- ^ “Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF”. J. Cell Biol. 163 (3): 489–502. (November 2003). doi:10.1083/jcb.200303017. PMC 2173632. PMID 14597771.
- ^ “Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF”. Biochem. Biophys. Res. Commun. 320 (2): 376–82. (July 2004). doi:10.1016/j.bbrc.2004.05.176. PMID 15219838.
- ^ “BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation”. J. Biol. Chem. 276 (32): 30127–32. (August 2001). doi:10.1074/jbc.M010237200. PMID 11340068.
- ^ “Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation”. Protein Pept. Lett. 11 (5): 501–8. (October 2004). doi:10.2174/0929866043406508. PMID 15544571.
- ^ “Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy”. Cancer Sci. 97 (5): 341–7. (May 2006). doi:10.1111/j.1349-7006.2006.00188.x. PMID 16630129.
- ^ “Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblasts”. Invest. Ophthalmol. Vis. Sci. 45 (1): 110–3. (January 2004). doi:10.1167/iovs.03-0046. PMID 14691161.
- ^ Miyazono K (January 2012). “Ectodomain shedding of HB-EGF: a potential target for cancer therapy”. J. Biochem. 151 (1): 1–3. doi:10.1093/jb/mvr120. PMID 21976708.
- ^ “ErbB and HB-EGF signaling in heart development and function”. Cell Struct. Funct. 31 (1): 1–14. (2006). doi:10.1247/csf.31.1. PMID 16508205.
- ^ “Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling”. Circ. Res. 102 (10): 1275–85. (May 2008). doi:10.1161/CIRCRESAHA.108.171728. PMC 2752633. PMID 18436796.
- ^ “Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing”. J. Cell Sci. 118 (Pt 11): 2363–70. (June 2005). doi:10.1242/jcs.02346. PMID 15923649.
- ^ “Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury”. Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3889–93. (May 1993). Bibcode: 1993PNAS...90.3889M. doi:10.1073/pnas.90.9.3889. PMC 46411. PMID 8483908.
- ^ “Heparin-binding EGF-like growth factor modulation by antiprogestin and CG in the baboon (Papio anubis)”. J. Clin. Endocrinol. Metab. 86 (9): 4520–8. (September 2001). doi:10.1210/jcem.86.9.7835. PMID 11549702.
- ^ “Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis”. Lab. Invest. 92 (3): 331–44. (March 2012). doi:10.1038/labinvest.2011.167. PMC 3289750. PMID 22157721.
- ^ “Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity”. Endocrinology 150 (6): 2683–91. (June 2009). doi:10.1210/en.2008-1647. PMID 19264873.
[続きの解説]
「HB-EGF」の続きの解説一覧
- 1 HB-EGFとは
- 2 HB-EGFの概要
- 3 相互作用
- 4 他の生理過程における役割
- HB-EGFのページへのリンク
