20α-ヒドロキシステロイドデヒドロゲナーゼ

ウィキペディア

20α-ヒドロキシステロイドデヒドロゲナーゼ

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2009/12/19 04:51 UTC 版)

20α-ヒドロキシステロイドデヒドロゲナーゼ
識別子
EC番号	1.1.1.149
CAS登録番号	9040-08-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	structures
遺伝子オントロジー	AmiGO / EGO
検索 PMC articles PubMed articles

20α-ヒドロキシステロイドデヒドロゲナーゼ（20α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。

17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ 17α-ヒドロキシプロゲステロン + NAD(P)H + H⁺

反応式の通り、この酵素の基質は17α,20α-ジヒドロキシプレグン-4-エン-3-オンとNAD(P)⁺、生成物は17α-ヒドロキシプロゲステロンとNAD(P)HとH⁺である。

組織名は20α-hydroxysteroid:NAD(P)⁺ 20-oxidoreductaseで、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。

参考文献

• Shikita M, Inano H, Tamaoki B (1967). “Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes”. Biochemistry. 6: 1760–4. DOI: 10.1021/bi00858a026. PMID 4382486.
• Strickler RC, Tobias B, Covey DF (1981). “Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site”. J. Biol. Chem. 256: 316–21. PMID 6935192.
• Wiest WG, Kidwell WR, Balogh K (1968 April). “Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational potency during pregnancy”. Endocrinology 82 (4): 844–59. PMID 5742200.

• Wiest WG (1968 December). “On the function of 20 alpha-hydroxypregn-4-en-3-one during parturition in the rat”. Endocrinology 83 (6): 1181–4. PMID 5721991.

• Piekorz RP, Gingras S, Hoffmeyer A, Ihle JN, Weinstein Y (2005 February). “Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase”. Mol. Endocrinol. 19 (2): 431–40. DOI: 10.1210/me.2004-0302. PMID 15471942.

• Akinola LA, Poutanen M, Vihko R, Vihko P (1997 July). “Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats”. Endocrinology 138 (7): 2886–92. PMID 9202232.

• Weinstein Y (1977 October). “20alpha-hydroxysteroid dehydrogenase: a T lymphocyte-associated enzyme”. J. Immunol. 119 (4): 1223–9. PMID 302277.

• Weinstein Y, Lindner HR, Eckstein B (1977 April). “Thymus metabolises progesterone- possible enzymatic marker for T lymphocytes”. Nature 266 (5603): 632–3. PMID 300849.

• Ihle JN, Keller J, Oroszlan S, Henderson LE, Copeland TD, Fitch F, Prystowsky MB, Goldwasser E, Schrader JW, Palaszynski E, Dy M, Lebel B (1983 July). “Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity”. J. Immunol. 131 (1): 282–7. PMID 6190911.

• Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y (2007 March). “Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone”. Endocrinology 148 (3): 976–88. DOI: 10.1210/en.2006-1100. PMID 17122075.