β細胞
(ベータ細胞 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/07 01:38 UTC 版)
β細胞（ベータさいぼう、英: beta cell, β cell）は、膵島でインスリンとアミリンの合成と分泌を行う細胞である。ヒトでは、膵島の細胞の50–70%をβ細胞が占める[1]。1型糖尿病や2型糖尿病の患者では、β細胞の細胞量と細胞機能がともに低下し、インスリン分泌不全と高血糖症が引き起こされる[2]。
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- ^ Hoogwerf BJ, Goetz FC (January 1983). "Urinary C-peptide: a simple measure of integrated insulin production with emphasis on the effects of body size, diet, and corticosteroids". The Journal of Clinical Endocrinology and Metabolism. 56 (1): 60–7. doi:10.1210/jcem-56-1-60. PMID 6336620。
- ^ Moore CX, Cooper GJ (August 1991). "Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents". Biochemical and Biophysical Research Communications. 179 (1): 1–9. doi:10.1016/0006-291X(91)91325-7. PMID 1679326。
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- ^ "U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group". Diabetes. 44 (11): 1249–58. November 1995. doi:10.2337/diabetes.44.11.1249. PMID 7589820。
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- ^ Yu, Run; Nissen, Nicholas N.; Hendifar, Andrew; Tang, Laura; Song, Yu-Li; Chen, Yuan-Jia; Fan, Xuemo (January 2017). “A Clinicopathological Study of Malignant Insulinoma in a Contemporary Series”. Pancreas 46 (1): 48–56. doi:10.1097/MPA.0000000000000718. ISSN 1536-4828. PMID 27984486.
- ^ Bolen, Shari; Feldman, Leonard; Vassy, Jason; Wilson, Lisa; Yeh, Hsin-Chieh; Marinopoulos, Spyridon; Wiley, Crystal; Selvin, Elizabeth et al. (2007-09-18). “Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus” (英語). Annals of Internal Medicine 147 (6): 386–99. doi:10.7326/0003-4819-147-6-200709180-00178. ISSN 0003-4819. PMID 17638715.
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- ^ a b Johannesson, Bjarki; Sui, Lina; Freytes, Donald O.; Creusot, Remi J.; Egli, Dieter (2015-04-01). “Toward beta cell replacement for diabetes”. The EMBO journal 34 (7): 841–855. doi:10.15252/embj.201490685. ISSN 1460-2075. PMC 4388595. PMID 25733347.
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- ^ Nunemaker, Craig S.; Bertram, Richard; Sherman, Arthur; Tsaneva-Atanasova, Krasimira; Daniel, Camille R.; Satin, Leslie S. (2006-09-15). “Glucose modulates [Ca2+i oscillations in pancreatic islets via ionic and glycolytic mechanisms”]. Biophysical Journal 91 (6): 2082–2096. doi:10.1529/biophysj.106.087296. ISSN 0006-3495. PMC 1557567. PMID 16815907.
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