KIT (タンパク質) KIT (タンパク質)の概要

KIT
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH
識別子
記号	KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase
外部ID	OMIM: 164920 MGI: 96677 HomoloGene: 187 GeneCards: KIT
遺伝子の位置 (ヒト)
染色体	4番染色体 (ヒト)
終点	54,740,715 bp
遺伝子の位置 (マウス)
染色体	5番染色体 (マウス)
終点	75,817,382 bp
遺伝子オントロジー
分子機能	• stem cell factor receptor activity; • キナーゼ活性; • transmembrane receptor protein tyrosine kinase activity; • ATP binding; • cytokine binding; • protein kinase activity; • 金属イオン結合; • transferase activity; • protein homodimerization activity; • protease binding; • 血漿タンパク結合; • protein tyrosine kinase activity; • ヌクレオチド結合; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 受容体型チロシンキナーゼ; • 膜貫通シグナル伝達受容体活性; • SH2 domain binding;
細胞の構成要素	• 細胞質; • 膜; • cell-cell junction; • cytoplasmic side of plasma membrane; • cell surface; • integral component of membrane; • 先体; • external side of plasma membrane; • mast cell granule; • 細胞外空間; • 細胞膜; • integral component of plasma membrane; • receptor complex;
生物学的プロセス	• melanocyte migration; • myeloid progenitor cell differentiation; • positive regulation of MAP kinase activity; • glycosphingolipid metabolic process; • positive regulation of phospholipase C activity; • hematopoietic stem cell migration; • stem cell population maintenance; • タンパク質リン酸化; • T cell differentiation; • 精子形成; • cell chemotaxis; • 発生中の色素沈着; • melanocyte differentiation; • positive regulation of Notch signaling pathway; • lamellipodium assembly; • サイトカイン媒介シグナル伝達経路; • transmembrane receptor protein tyrosine kinase signaling pathway; • melanocyte adhesion; • lymphoid progenitor cell differentiation; • spermatid development; • erythrocyte differentiation; • negative regulation of programmed cell death; • 自己リン酸化; • mast cell degranulation; • 炎症反応; • positive regulation of MAPK cascade; • myeloid leukocyte differentiation; • 男性生殖腺発生; • リン酸化; • positive regulation of DNA-binding transcription factor activity; • epithelial cell proliferation; • stem cell differentiation; • detection of mechanical stimulus involved in sensory perception of sound; • regulation of cell shape; • 卵胞発生; • ectopic germ cell programmed cell death; • 色素沈着; • Fc receptor signaling pathway; • response to radiation; • mast cell cytokine production; • positive regulation of receptor signaling pathway via JAK-STAT; • dendritic cell cytokine production; • visual learning; • actin cytoskeleton reorganization; • megakaryocyte development; • intracellular signal transduction; • somatic stem cell population maintenance; • erythropoietin-mediated signaling pathway; • Kit signaling pathway; • positive regulation of cell migration; • somatic stem cell division; • mast cell chemotaxis; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of pseudopodium assembly; • positive regulation of gene expression; • positive regulation of long-term neuronal synaptic plasticity; • regulation of cell population proliferation; • cellular response to thyroid hormone stimulus; • positive regulation of cell population proliferation; • embryonic hemopoiesis; • regulation of developmental pigmentation; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • mast cell differentiation; • 消化管発生; • immature B cell differentiation; • germ cell migration; • シグナル伝達; • mast cell proliferation; • positive regulation of vascular associated smooth muscle cell differentiation; • phosphatidylinositol phosphate biosynthetic process; • regulation of transcription by RNA polymerase II; • positive regulation of tyrosine phosphorylation of STAT protein; • tongue development; • response to cadmium ion; • positive regulation of pyloric antrum smooth muscle contraction; • regulation of bile acid metabolic process; • positive regulation of small intestine smooth muscle contraction; • positive regulation of colon smooth muscle contraction; • positive regulation of protein kinase B signaling; • 造血; • negative regulation of signal transduction; • 細胞分化; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • hematopoietic progenitor cell differentiation; • B cell differentiation;
	出典:Amigo / QuickGO
オルソログ
	3815
	16590
	ENSG00000157404
	ENSMUSG00000005672
	P10721
	P05532
	NM_000222; NM_001093772
	NM_001122733; NM_021099
	NP_000213; NP_001087241
	NP_001116205; NP_066922
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157404 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005672 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics 39 (2): 216–226. (January 1997). doi:10.1006/geno.1996.4482. PMID 9027509.
^ ^a ^b “Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog”. 2023年7月17日閲覧。
^ “https://www.cancer.gov/publications/dictionaries/cancer-terms” (英語). www.cancer.gov (2011年2月2日). 2023年7月17日閲覧。
^ “Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand”. The EMBO Journal 6 (11): 3341–3351. (November 1987). doi:10.1002/j.1460-2075.1987.tb02655.x. PMC 553789. PMID 2448137.
^ “c-Kit--a hematopoietic cell essential receptor tyrosine kinase”. The International Journal of Biochemistry & Cell Biology 39 (11): 1995–1998. (2007). doi:10.1016/j.biocel.2006.12.005. PMID 17350321.
^ ^a ^b “Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis”. The EMBO Journal 10 (13): 4121–4128. (December 1991). doi:10.1002/j.1460-2075.1991.tb04989.x. PMC 453162. PMID 1721869.
^ Brooks, Samantha (2006). Studies of genetic variability at the KIT locus and white spotting patterns in the horse (Thesis). University of Kentucky Doctoral Dissertations. pp. 13–16.
^ “Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor”. Biochemical and Biophysical Research Communications 338 (3): 1307–1315. (December 2005). doi:10.1016/j.bbrc.2005.09.150. PMID 16226710.
^ “Allelic heterogeneity at the equine KIT locus in dominant white (W) horses”. PLOS Genetics 3 (11): e195. (November 2007). doi:10.1371/journal.pgen.0030195. PMC 2065884. PMID 17997609.
^ “Generation of a prostate from a single adult stem cell”. Nature 456 (7223): 804–808. (December 2008). Bibcode: 2008Natur.456..804L. doi:10.1038/nature07427. PMID 18946470.
^ “Innate Lymphoid Cells in Cancer”. Cancer Immunology Research 3 (10): 1109–1114. (October 2015). doi:10.1158/2326-6066.CIR-15-0222. PMID 26438443.
^ ^a ^b “Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review”. Bosnian Journal of Basic Medical Sciences 22 (5): 683–698. (April 2022). doi:10.17305/bjbms.2021.7399. PMC 9519160. PMID 35490363.
^ Jean-Loup Huret. “KIT”. Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2008年3月1日閲覧。
^ “Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults”. Cancer Research 65 (18): 8085–8089. (September 2005). doi:10.1158/0008-5472.CAN-05-0471. PMID 16166280.
^ “Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight”. Journal of Biomolecular Structure & Dynamics 32 (7): 1033–1046. (2014). doi:10.1080/07391102.2013.803264. PMID 23782055.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd.. pp. 149–151. ISBN 978-1-84110-100-2
^ “The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit”. The Biochemical Journal 370 (Pt 3): 1033–1038. (March 2003). doi:10.1042/BJ20020716. PMC 1223215. PMID 12444928.
^ “Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells”. British Journal of Haematology 94 (1): 5–16. (July 1996). doi:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502.
^ ^a ^b ^c “C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood 99 (12): 4413–4421. (June 2002). doi:10.1182/blood.V99.12.4413. PMID 12036870.
^ “Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Experimental Cell Research 288 (1): 110–118. (August 2003). doi:10.1016/S0014-4827(03)00206-4. PMID 12878163.
^ ^a ^b “Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–3413. (November 2000). doi:10.1182/blood.V96.10.3406. PMID 11071635.
^ “Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. The Journal of Biological Chemistry 272 (15): 10248–10253. (April 1997). doi:10.1074/jbc.272.15.10248. PMID 9092574.
^ ^a ^b “Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. The Journal of Biological Chemistry 277 (16): 13732–13738. (April 2002). doi:10.1074/jbc.M200277200. PMID 11825908.
^ “FES kinase participates in KIT-ligand induced chemotaxis”. Biochemical and Biophysical Research Communications 393 (1): 174–178. (February 2010). doi:10.1016/j.bbrc.2010.01.116. PMID 20117079.
^ “Role for the adaptor protein Grb10 in the activation of Akt”. Molecular and Cellular Biology 22 (4): 979–991. (February 2002). doi:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791.
^ ^a ^b ^c “Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation”. The EMBO Journal 18 (4): 904–915. (February 1999). doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
^ “Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor”. The Biochemical Journal 341 (1): 211–216. (July 1999). doi:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264.
^ “Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. The Journal of Biological Chemistry 271 (21): 12129–12132. (May 1996). doi:10.1074/jbc.271.21.12129. PMID 8647802.
^ “A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. The Journal of Biological Chemistry 267 (15): 10866–10873. (May 1992). doi:10.1016/S0021-9258(19)50098-9. PMID 1375232.
^ “Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. The Journal of Biological Chemistry 268 (6): 4399–4406. (February 1993). doi:10.1016/S0021-9258(18)53623-1. PMID 7680037.
^ “Adaptor protein Lnk associates with Tyr(568) in c-Kit”. The Biochemical Journal 415 (2): 241–245. (October 2008). doi:10.1042/BJ20080102. PMID 18588518.
^ “Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. The Journal of Biological Chemistry 272 (43): 27450–27455. (October 1997). doi:10.1074/jbc.272.43.27450. PMID 9341198.
^ “The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. The Journal of Biological Chemistry 270 (16): 9661–9666. (April 1995). doi:10.1074/jbc.270.16.9661. PMID 7536744.
^ “Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. The Journal of Biological Chemistry 272 (9): 5915–5920. (February 1997). doi:10.1074/jbc.272.9.5915. PMID 9038210.
^ “The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Letters 482 (1–2): 54–58. (September 2000). doi:10.1016/S0014-5793(00)02036-6. PMID 11018522.
^ “Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. The Journal of Biological Chemistry 269 (8): 6026–6030. (February 1994). doi:10.1016/S0021-9258(17)37564-6. PMID 7509796.
^ “The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. The Journal of Biological Chemistry 269 (40): 25206–25211. (October 1994). doi:10.1016/S0021-9258(17)31518-1. PMID 7523381.
^ ^a ^b “SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain”. Molecular and Cellular Biology 18 (4): 2089–2099. (April 1998). doi:10.1128/MCB.18.4.2089. PMC 121439. PMID 9528781.
^ “Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand”. Molecular and Cellular Biology 13 (6): 3350–3358. (June 1993). doi:10.1128/MCB.13.6.3350. PMC 359793. PMID 7684496.
^ “Stat1 associates with c-kit and is activated in response to stem cell factor”. The Biochemical Journal 327 (1): 73–80. (October 1997). doi:10.1042/bj3270073. PMC 1218765. PMID 9355737.
^ “Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. The Journal of Biological Chemistry 279 (13): 12249–12259. (March 2004). doi:10.1074/jbc.M313381200. PMID 14707129.
^ “Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene 18 (40): 5546–5553. (September 1999). doi:10.1038/sj.onc.1202929. PMID 10523831.
^ “Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding”. Molecular and Cellular Biology 14 (12): 8432–8437. (December 1994). doi:10.1128/MCB.14.12.8432. PMC 359382. PMID 7526158.

[前の解説]

[続きの解説]

「KIT (タンパク質)」の続きの解説一覧

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157404 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005672 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid9027509-5] “Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics 39 (2): 216–226. (January 1997). doi:10.1006/geno.1996.4482. PMID 9027509.

[entrez-6] “Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog”. 2023年7月17日閲覧。

[:0-7] “https://www.cancer.gov/publications/dictionaries/cancer-terms” (英語). www.cancer.gov (2011年2月2日). 2023年7月17日閲覧。

[pmid2448137-8] “Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand”. The EMBO Journal 6 (11): 3341–3351. (November 1987). doi:10.1002/j.1460-2075.1987.tb02655.x. PMC 553789. PMID 2448137.

[pmid17350321-9] “c-Kit--a hematopoietic cell essential receptor tyrosine kinase”. The International Journal of Biochemistry & Cell Biology 39 (11): 1995–1998. (2007). doi:10.1016/j.biocel.2006.12.005. PMID 17350321.

[Blume-Jensen1991-10] “Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis”. The EMBO Journal 10 (13): 4121–4128. (December 1991). doi:10.1002/j.1460-2075.1991.tb04989.x. PMC 453162. PMID 1721869.

[:1-11] Brooks, Samantha (2006). Studies of genetic variability at the KIT locus and white spotting patterns in the horse (Thesis). University of Kentucky Doctoral Dissertations. pp. 13–16.

[Roskoski2005-12] “Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor”. Biochemical and Biophysical Research Communications 338 (3): 1307–1315. (December 2005). doi:10.1016/j.bbrc.2005.09.150. PMID 16226710.

[Haase2007-13] “Allelic heterogeneity at the equine KIT locus in dominant white (W) horses”. PLOS Genetics 3 (11): e195. (November 2007). doi:10.1371/journal.pgen.0030195. PMC 2065884. PMID 17997609.

[pmid18946470-14] “Generation of a prostate from a single adult stem cell”. Nature 456 (7223): 804–808. (December 2008). Bibcode: 2008Natur.456..804L. doi:10.1038/nature07427. PMID 18946470.

[:2-15] “Innate Lymphoid Cells in Cancer”. Cancer Immunology Research 3 (10): 1109–1114. (October 2015). doi:10.1158/2326-6066.CIR-15-0222. PMID 26438443.

[Sheikh_2022-16] “Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review”. Bosnian Journal of Basic Medical Sciences 22 (5): 683–698. (April 2022). doi:10.17305/bjbms.2021.7399. PMC 9519160. PMID 35490363.

[titleKIT-17] Jean-Loup Huret. “KIT”. Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2008年3月1日閲覧。

[pmid16166280-18] “Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults”. Cancer Research 65 (18): 8085–8089. (September 2005). doi:10.1158/0008-5472.CAN-05-0471. PMID 16166280.

[pmid23782055-19] “Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight”. Journal of Biomolecular Structure & Dynamics 32 (7): 1033–1046. (2014). doi:10.1080/07391102.2013.803264. PMID 23782055.

[Leong-20] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd.. pp. 149–151. ISBN 978-1-84110-100-2

[pmid12444928-21] “The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit”. The Biochemical Journal 370 (Pt 3): 1033–1038. (March 2003). doi:10.1042/BJ20020716. PMC 1223215. PMID 12444928.

[pmid8757502-22] “Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells”. British Journal of Haematology 94 (1): 5–16. (July 1996). doi:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502.

[pmid12036870-23] “C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood 99 (12): 4413–4421. (June 2002). doi:10.1182/blood.V99.12.4413. PMID 12036870.

[pmid12878163-24] “Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Experimental Cell Research 288 (1): 110–118. (August 2003). doi:10.1016/S0014-4827(03)00206-4. PMID 12878163.

[pmid11071635-25] “Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–3413. (November 2000). doi:10.1182/blood.V96.10.3406. PMID 11071635.

[pmid9092574-26] “Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. The Journal of Biological Chemistry 272 (15): 10248–10253. (April 1997). doi:10.1074/jbc.272.15.10248. PMID 9092574.

[pmid11825908-27] “Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. The Journal of Biological Chemistry 277 (16): 13732–13738. (April 2002). doi:10.1074/jbc.M200277200. PMID 11825908.

[pmid20117079-28] “FES kinase participates in KIT-ligand induced chemotaxis”. Biochemical and Biophysical Research Communications 393 (1): 174–178. (February 2010). doi:10.1016/j.bbrc.2010.01.116. PMID 20117079.

[pmid11809791-29] “Role for the adaptor protein Grb10 in the activation of Akt”. Molecular and Cellular Biology 22 (4): 979–991. (February 2002). doi:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791.

[pmid10022833-30] “Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation”. The EMBO Journal 18 (4): 904–915. (February 1999). doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.

[pmid10377264-31] “Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor”. The Biochemical Journal 341 (1): 211–216. (July 1999). doi:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264.

[pmid8647802-32] “Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. The Journal of Biological Chemistry 271 (21): 12129–12132. (May 1996). doi:10.1074/jbc.271.21.12129. PMID 8647802.

[pmid1375232-33] “A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. The Journal of Biological Chemistry 267 (15): 10866–10873. (May 1992). doi:10.1016/S0021-9258(19)50098-9. PMID 1375232.

[pmid7680037-34] “Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. The Journal of Biological Chemistry 268 (6): 4399–4406. (February 1993). doi:10.1016/S0021-9258(18)53623-1. PMID 7680037.

[pmid18588518-35] “Adaptor protein Lnk associates with Tyr(568) in c-Kit”. The Biochemical Journal 415 (2): 241–245. (October 2008). doi:10.1042/BJ20080102. PMID 18588518.

[pmid9341198-36] “Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. The Journal of Biological Chemistry 272 (43): 27450–27455. (October 1997). doi:10.1074/jbc.272.43.27450. PMID 9341198.

[pmid7536744-37] “The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. The Journal of Biological Chemistry 270 (16): 9661–9666. (April 1995). doi:10.1074/jbc.270.16.9661. PMID 7536744.

[pmid9038210-38] “Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. The Journal of Biological Chemistry 272 (9): 5915–5920. (February 1997). doi:10.1074/jbc.272.9.5915. PMID 9038210.

[pmid11018522-39] “The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Letters 482 (1–2): 54–58. (September 2000). doi:10.1016/S0014-5793(00)02036-6. PMID 11018522.

[pmid7509796-40] “Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. The Journal of Biological Chemistry 269 (8): 6026–6030. (February 1994). doi:10.1016/S0021-9258(17)37564-6. PMID 7509796.

[pmid7523381-41] “The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. The Journal of Biological Chemistry 269 (40): 25206–25211. (October 1994). doi:10.1016/S0021-9258(17)31518-1. PMID 7523381.

[pmid9528781-42] “SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain”. Molecular and Cellular Biology 18 (4): 2089–2099. (April 1998). doi:10.1128/MCB.18.4.2089. PMC 121439. PMID 9528781.

[pmid7684496-43] “Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand”. Molecular and Cellular Biology 13 (6): 3350–3358. (June 1993). doi:10.1128/MCB.13.6.3350. PMC 359793. PMID 7684496.

[pmid9355737-44] “Stat1 associates with c-kit and is activated in response to stem cell factor”. The Biochemical Journal 327 (1): 73–80. (October 1997). doi:10.1042/bj3270073. PMC 1218765. PMID 9355737.

[pmid14707129-45] “Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. The Journal of Biological Chemistry 279 (13): 12249–12259. (March 2004). doi:10.1074/jbc.M313381200. PMID 14707129.

[pmid10523831-46] “Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene 18 (40): 5546–5553. (September 1999). doi:10.1038/sj.onc.1202929. PMID 10523831.

[pmid7526158-47] “Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding”. Molecular and Cellular Biology 14 (12): 8432–8437. (December 1994). doi:10.1128/MCB.14.12.8432. PMC 359382. PMID 7526158.

[1]

[2]

[3]

[4]

KIT (タンパク質) KIT (タンパク質)の概要

KIT (タンパク質)

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