KIT (タンパク質)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/07/30 15:17 UTC 版)
外部リンク
- Proto-Oncogene Proteins c-kit - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス(英語)
- C-kit receptor entry in the public domain NCI Dictionary of Cancer Terms
- Human KIT genome location and KIT gene details page in the UCSC Genome Browser.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000157404 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005672 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics 39 (2): 216–226. (January 1997). doi:10.1006/geno.1996.4482. PMID 9027509.
- ^ a b “Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog”. 2023年7月17日閲覧。
- ^ “https://www.cancer.gov/publications/dictionaries/cancer-terms” (英語). www.cancer.gov (2011年2月2日). 2023年7月17日閲覧。
- ^ “Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand”. The EMBO Journal 6 (11): 3341–3351. (November 1987). doi:10.1002/j.1460-2075.1987.tb02655.x. PMC 553789. PMID 2448137 .
- ^ “c-Kit--a hematopoietic cell essential receptor tyrosine kinase”. The International Journal of Biochemistry & Cell Biology 39 (11): 1995–1998. (2007). doi:10.1016/j.biocel.2006.12.005. PMID 17350321.
- ^ a b “Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis”. The EMBO Journal 10 (13): 4121–4128. (December 1991). doi:10.1002/j.1460-2075.1991.tb04989.x. PMC 453162. PMID 1721869 .
- ^ Brooks, Samantha (2006). Studies of genetic variability at the KIT locus and white spotting patterns in the horse (Thesis). University of Kentucky Doctoral Dissertations. pp. 13–16.
- ^ “Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor”. Biochemical and Biophysical Research Communications 338 (3): 1307–1315. (December 2005). doi:10.1016/j.bbrc.2005.09.150. PMID 16226710.
- ^ “Allelic heterogeneity at the equine KIT locus in dominant white (W) horses”. PLOS Genetics 3 (11): e195. (November 2007). doi:10.1371/journal.pgen.0030195. PMC 2065884. PMID 17997609 .
- ^ “Generation of a prostate from a single adult stem cell”. Nature 456 (7223): 804–808. (December 2008). Bibcode: 2008Natur.456..804L. doi:10.1038/nature07427. PMID 18946470.
- ^ “Innate Lymphoid Cells in Cancer”. Cancer Immunology Research 3 (10): 1109–1114. (October 2015). doi:10.1158/2326-6066.CIR-15-0222. PMID 26438443.
- ^ a b “Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review”. Bosnian Journal of Basic Medical Sciences 22 (5): 683–698. (April 2022). doi:10.17305/bjbms.2021.7399. PMC 9519160. PMID 35490363 .
- ^ Jean-Loup Huret. “KIT”. Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2008年3月1日閲覧。
- ^ “Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults”. Cancer Research 65 (18): 8085–8089. (September 2005). doi:10.1158/0008-5472.CAN-05-0471. PMID 16166280.
- ^ “Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight”. Journal of Biomolecular Structure & Dynamics 32 (7): 1033–1046. (2014). doi:10.1080/07391102.2013.803264. PMID 23782055 .
- ^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd.. pp. 149–151. ISBN 978-1-84110-100-2
- ^ “The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit”. The Biochemical Journal 370 (Pt 3): 1033–1038. (March 2003). doi:10.1042/BJ20020716. PMC 1223215. PMID 12444928 .
- ^ “Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells”. British Journal of Haematology 94 (1): 5–16. (July 1996). doi:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502.
- ^ a b c “C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood 99 (12): 4413–4421. (June 2002). doi:10.1182/blood.V99.12.4413. PMID 12036870.
- ^ “Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Experimental Cell Research 288 (1): 110–118. (August 2003). doi:10.1016/S0014-4827(03)00206-4. PMID 12878163.
- ^ a b “Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–3413. (November 2000). doi:10.1182/blood.V96.10.3406. PMID 11071635 .
- ^ “Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. The Journal of Biological Chemistry 272 (15): 10248–10253. (April 1997). doi:10.1074/jbc.272.15.10248. PMID 9092574.
- ^ a b “Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. The Journal of Biological Chemistry 277 (16): 13732–13738. (April 2002). doi:10.1074/jbc.M200277200. PMID 11825908.
- ^ “FES kinase participates in KIT-ligand induced chemotaxis”. Biochemical and Biophysical Research Communications 393 (1): 174–178. (February 2010). doi:10.1016/j.bbrc.2010.01.116. PMID 20117079.
- ^ “Role for the adaptor protein Grb10 in the activation of Akt”. Molecular and Cellular Biology 22 (4): 979–991. (February 2002). doi:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791 .
- ^ a b c “Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation”. The EMBO Journal 18 (4): 904–915. (February 1999). doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833 .
- ^ “Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor”. The Biochemical Journal 341 (1): 211–216. (July 1999). doi:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264 .
- ^ “Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. The Journal of Biological Chemistry 271 (21): 12129–12132. (May 1996). doi:10.1074/jbc.271.21.12129. PMID 8647802.
- ^ “A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. The Journal of Biological Chemistry 267 (15): 10866–10873. (May 1992). doi:10.1016/S0021-9258(19)50098-9. PMID 1375232.
- ^ “Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. The Journal of Biological Chemistry 268 (6): 4399–4406. (February 1993). doi:10.1016/S0021-9258(18)53623-1. PMID 7680037.
- ^ “Adaptor protein Lnk associates with Tyr(568) in c-Kit”. The Biochemical Journal 415 (2): 241–245. (October 2008). doi:10.1042/BJ20080102. PMID 18588518.
- ^ “Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. The Journal of Biological Chemistry 272 (43): 27450–27455. (October 1997). doi:10.1074/jbc.272.43.27450. PMID 9341198.
- ^ “The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. The Journal of Biological Chemistry 270 (16): 9661–9666. (April 1995). doi:10.1074/jbc.270.16.9661. PMID 7536744.
- ^ “Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. The Journal of Biological Chemistry 272 (9): 5915–5920. (February 1997). doi:10.1074/jbc.272.9.5915. PMID 9038210.
- ^ “The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Letters 482 (1–2): 54–58. (September 2000). doi:10.1016/S0014-5793(00)02036-6. PMID 11018522.
- ^ “Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. The Journal of Biological Chemistry 269 (8): 6026–6030. (February 1994). doi:10.1016/S0021-9258(17)37564-6. PMID 7509796.
- ^ “The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. The Journal of Biological Chemistry 269 (40): 25206–25211. (October 1994). doi:10.1016/S0021-9258(17)31518-1. PMID 7523381.
- ^ a b “SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain”. Molecular and Cellular Biology 18 (4): 2089–2099. (April 1998). doi:10.1128/MCB.18.4.2089. PMC 121439. PMID 9528781 .
- ^ “Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand”. Molecular and Cellular Biology 13 (6): 3350–3358. (June 1993). doi:10.1128/MCB.13.6.3350. PMC 359793. PMID 7684496 .
- ^ “Stat1 associates with c-kit and is activated in response to stem cell factor”. The Biochemical Journal 327 (1): 73–80. (October 1997). doi:10.1042/bj3270073. PMC 1218765. PMID 9355737 .
- ^ “Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. The Journal of Biological Chemistry 279 (13): 12249–12259. (March 2004). doi:10.1074/jbc.M313381200. PMID 14707129.
- ^ “Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene 18 (40): 5546–5553. (September 1999). doi:10.1038/sj.onc.1202929. PMID 10523831.
- ^ “Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding”. Molecular and Cellular Biology 14 (12): 8432–8437. (December 1994). doi:10.1128/MCB.14.12.8432. PMC 359382. PMID 7526158 .
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