β2-ミクログロブリン β2-ミクログロブリンの概要

B2M
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1A1M, 1A1N, 1A1O, 1A6Z, 1A9B, 1A9E, 1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1AKJ, 1AO7, 1B0G, 1B0R, 1BD2, 1C16, 1CE6, 1DE4, 1DUY, 1DUZ, 1E27, 1E28, 1EEY, 1EEZ, 1EFX, 1EXU, 1GZP, 1GZQ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1HSA, 1HSB, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1IM9, 1JF1, 1JGD, 1JGE, 1JHT, 1JNJ, 1K5N, 1KPR, 1KTL, 1LDS, 1LP9, 1M05, 1M6O, 1MHE, 1MI5, 1OF2, 1OGA, 1OGT, 1ONQ, 1PY4, 1Q94, 1QEW, 1QLF, 1QQD, 1QR1, 1QRN, 1QSE, 1QSF, 1QVO, 1R3H, 1S9W, 1S9X, 1S9Y, 1SYS, 1SYV, 1TMC, 1TVB, 1TVH, 1UQS, 1UXS, 1UXW, 1VGK, 1W0V, 1W0W, 1W72, 1X7Q, 1XH3, 1XR8, 1XR9, 1XZ0, 1YDP, 1YPZ, 1ZHK, 1ZHL, 1ZS8, 1ZSD, 1ZT4, 1ZVS, 2A83, 2AK4, 2AV7, 2AXF, 2AXG, 2BCK, 2BNQ, 2BNR, 2BSR, 2BSS, 2BST, 2BVO, 2BVP, 2BVQ, 2C7U, 2CII, 2CIK, 2CLR, 2D31, 2D4D, 2D4F, 2DYP, 2E8D, 2ESV, 2F53, 2F54, 2F74, 2F8O, 2GIT, 2GJ6, 2GT9, 2GTW, 2GTZ, 2GUO, 2H26, 2H6P, 2HJL, 2HLA, 2HN7, 2J8U, 2JCC, 2NW3, 2NX5, 2P5E, 2P5W, 2PO6, 2PYE, 2RFX, 2UWE, 2V2W, 2V2X, 2VB5, 2VLJ, 2VLK, 2VLL, 2VLR, 2X4N, 2X4O, 2X4P, 2X4Q, 2X4R, 2X4S, 2X4T, 2X4U, 2X70, 2X89, 2XKS, 2XKU, 2XPG, 2YPK, 2YPL, 2YXF, 2Z9T, 3AM8, 3B3I, 3B6S, 3BGM, 3BH8, 3BH9, 3BHB, 3BO8, 3BP4, 3BP7, 3BVN, 3BW9, 3BWA, 3BXN, 3BZE, 3BZF, 3C9N, 3CDG, 3CII, 3CIQ, 3CZF, 3D18, 3D25, 3D2U, 3D39, 3D3V, 3DBX, 3DHJ, 3DHM, 3DTX, 3DXA, 3EKC, 3FFC, 3FQN, 3FQR, 3FQT, 3FQU, 3FQW, 3FQX, 3FT2, 3FT3, 3FT4, 3GIV, 3GJF, 3GSN, 3GSO, 3GSQ, 3GSR, 3GSU, 3GSV, 3GSW, 3GSX, 3H7B, 3H9H, 3H9S, 3HAE, 3HCV, 3HG1, 3HLA, 3HPJ, 3HUJ, 3I6G, 3I6K, 3I6L, 3IB4, 3IXA, 3JTS, 3KLA, 3KPO, 3KPR, 3KPS, 3KWW, 3KXF, 3KYN, 3KYO, 3L3D, 3L3G, 3L3I, 3L3J, 3L3K, 3LKN, 3LKO, 3LKP, 3LKQ, 3LKR, 3LKS, 3LN4, 3LN5, 3LOW, 3LV3, 3M17, 3M1B, 3MGO, 3MGT, 3MR9, 3MRB, 3MRC, 3MRD, 3MRE, 3MRF, 3MRG, 3MRH, 3MRI, 3MRJ, 3MRK, 3MRL, 3MRM, 3MRN, 3MRO, 3MRP, 3MRQ, 3MRR, 3MV7, 3MV8, 3MV9, 3MYJ, 3MYZ, 3MZT, 3NA4, 3NFN, 3O3A, 3O3B, 3O3D, 3O3E, 3O4L, 3OX8, 3OXR, 3OXS, 3PWJ, 3PWL, 3PWN, 3PWP, 3QDA, 3QDG, 3QDJ, 3QDM, 3QEQ, 3QFD, 3QFJ, 3QZW, 3RL1, 3RWJ, 3S6C, 3SDX, 3SJV, 3SKM, 3SKO, 3SPV, 3T8X, 3TID, 3TIE, 3TLR, 3TM6, 3TO2, 3TZV, 3U0P, 3UPR, 3UTQ, 3UTS, 3UTT, 3V5D, 3V5H, 3V5K, 3VCL, 3VFR, 3VFS, 3VFT, 3VFU, 3VFV, 3VFW, 3VH8, 3VRI, 3VRJ, 3VWJ, 3VWK, 3W39, 4E0K, 4E0L, 4E5X, 4EN3, 4EUP, 4F7M, 4F7P, 4F7T, 4FTV, 4FXL, 4G8G, 4G8I, 4G9D, 4G9F, 4GKS, 4GUP, 4HKJ, 4I4W, 4JFD, 4JFE, 4JFF, 4JFO, 4JFP, 4JFQ, 4JQX, 4JRX, 4JRY, 4K7F, 4KDT, 4L4T, 4L4V, 1CG9, 1N2R, 1P7Q, 1S8D, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 2AV1, 2FYY, 2FZ3, 2HJK, 3DX6, 3DX7, 3DX8, 3KPL, 3KPM, 3KPN, 3KPP, 3KPQ, 3LOZ, 3OV6, 3REW, 3RL2, 3VXM, 3VXN, 3VXO, 3VXP, 3VXR, 3VXS, 3VXU, 3W0W, 3WL9, 3WLB, 3WUW, 3X11, 3X12, 3X13, 3X14, 4GKN, 4HWZ, 4HX1, 4I48, 4K71, 4L29, 4L3C, 4L3E, 4LCW, 4LCY, 4LHU, 4LNR, 4M8V, 4MJ5, 4MJ6, 4MJI, 4MNQ, 4N0F, 4N0U, 4N8V, 4NNX, 4NNY, 4NO0, 4NO2, 4NO3, 4NO5, 4NQC, 4NQD, 4NQE, 4NQV, 4NQX, 4NT6, 4O2C, 4O2E, 4O2F, 4ONO, 4PJ5, 4PJ7, 4PJ8, 4PJ9, 4PJA, 4PJB, 4PJC, 4PJD, 4PJE, 4PJF, 4PJG, 4PJH, 4PJI, 4PJX, 4PR5, 4PRA, 4PRB, 4PRD, 4PRE, 4PRH, 4PRI, 4PRN, 4PRP, 4QOK, 4QRP, 4QRQ, 4QRR, 4QRS, 4QRT, 4QRU, 4U1H, 4U1I, 4U1J, 4U1K, 4U1L, 4U1M, 4U1N, 4U1S, 4U6X, 4U6Y, 4UQ2, 4UQ3, 4WJ5, 4WO4, 4WU5, 4WU7, 4X6C, 4X6D, 4X6E, 4X6F, 4XXC, 4WDI, 4Z76, 4Z77, 4Z78, 4R9H, 4RA3, 4RAH, 5D2L, 5D2N, 4WW2, 5DEG, 4RMT, 5DEF, 4RMW, 4RMV, 4RMR, 5D7J, 4RMQ, 4RMS, 4WWK, 5BXF, 5D5M, 5D7L, 4RMU, 4WUU, 5D7I, 5EU5, 5EO0, 5EO1, 5EU4, 5BRZ, 5EU6, 5BS0, 5EU3, 5C9J, 5D9S, 5HGA, 5C0D, 5C0B, 5C0I, 5C0A, 5B38, 5E9D, 5B39, 5C0H, 5HHN, 5HGD, 5C08, 5CFH, 5CKG, 4ZEZ, 5C0C, 5HGH, 5C0J, 5HHQ, 5DDH, 5HHM, 5HGB, 5C09, 5HYJ, 5CKA, 5C07, 5HHP, 5C0G, 5C0F, 5HHO, 5C0E
識別子
記号	B2M, entrez:567, IMD43, beta-2-microglobulin, Β2 microglobulin
外部ID	OMIM: 109700 MGI: 88127 HomoloGene: 2987 GeneCards: B2M
遺伝子の位置 (ヒト)
染色体	15番染色体 (ヒト)
終点	44,718,851 bp
遺伝子の位置 (マウス)
染色体	2番染色体 (マウス)
終点	121,983,564 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 血漿タンパク結合; • identical protein binding;
細胞の構成要素	• HFE-transferrin receptor complex; • ゴルジ体; • phagocytic vesicle membrane; • early endosome membrane; • endoplasmic reticulum lumen; • 膜; • 焦点接着; • ゴルジ膜; • 細胞膜; • 細胞外領域; • MHC class I protein complex; • ER to Golgi transport vesicle membrane; • early endosome lumen; • エキソソーム; • external side of plasma membrane; • 細胞外空間; • 細胞質基質; • cell surface; • specific granule lumen; • recycling endosome membrane; • tertiary granule lumen; • ペプチドローディング複合体;
生物学的プロセス	• positive regulation of receptor-mediated endocytosis; • cellular response to iron ion; • response to cadmium ion; • negative regulation of receptor binding; • negative regulation of neuron projection development; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • T cell differentiation in thymus; • 免疫系プロセス; • interferon-gamma-mediated signaling pathway; • antigen processing and presentation of peptide antigen via MHC class I; • iron ion homeostasis; • positive regulation of T cell mediated cytotoxicity; • mitigation of host defenses by virus; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; • regulation of membrane depolarization; • antigen processing and presentation of endogenous peptide antigen via MHC class I; • positive regulation of ferrous iron binding; • positive regulation of transferrin receptor binding; • retina homeostasis; • positive regulation of T cell cytokine production; • protein refolding; • 免疫応答; • regulation of immune response; • positive regulation of receptor binding; • positive regulation of protein binding; • 自然免疫; • cellular response to lipopolysaccharide; • 細菌起源の分子への反応; • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; • iron ion transport; • 好中球脱顆粒; • regulation of erythrocyte differentiation; • cellular response to iron(III) ion; • antimicrobial humoral immune response mediated by antimicrobial peptide; • positive regulation of iron ion import across plasma membrane; • regulation of iron ion transport;
	出典:Amigo / QuickGO
オルソログ
	567
	12010
	ENSG00000166710; ENSG00000273686
	ENSMUSG00000060802
	P61769
	P01887
	NM_004048
	NM_009735
	NP_004039
	NP_033865
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166710、ENSG00000273686 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060802 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Entrez Gene: Beta-2-microglobulin”. 2023年1月22日閲覧。
^ ^a ^b “The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit”. Journal of Immunology 139 (9): 3132–8. (November 1987). PMID 3312414.
^ “The complete amino acid sequence of beta 2-microglobulin”. Biochemistry 12 (24): 4811–22. (November 1973). doi:10.1021/bi00748a001. PMID 4586824.
^ “Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin”. Proceedings of the National Academy of Sciences of the United States of America 78 (11): 6613–7. (November 1981). Bibcode: 1981PNAS...78.6613S. doi:10.1073/pnas.78.11.6613. PMC 349099. PMID 6171820.
^ Singh, Ram Raj; Yang, Jun-Qi; Kim, Peter J.; Halder, Ramesh C. (2013-03-27). “Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus”. Arthritis Research & Therapy 15 (2): R47. doi:10.1186/ar4206. ISSN 1478-6362. PMC 3672782. PMID 23531237.
^ “Chapter 3: Iron, Heme, and Hemoglobin”. Hematology: A Pathophysiologic Approach (1st ed.). (2011). pp. 17–25. ISBN 978-0-323-04311-3
^ del Val, M.; Hengel, H.; Häcker, H.; Hartlaub, U.; Ruppert, T.; Lucin, P.; Koszinowski, U. H. (1992-09-01). “Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment”. The Journal of Experimental Medicine 176 (3): 729–738. doi:10.1084/jem.176.3.729. ISSN 0022-1007. PMC 2119349. PMID 1324970.
^ Zijlstra, M.; Bix, M.; Simister, N. E.; Loring, J. M.; Raulet, D. H.; Jaenisch, R. (1990-04-19). “Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells”. Nature 344 (6268): 742–746. doi:10.1038/344742a0. ISSN 0028-0836. PMID 2139497.
^ Morgan, C. J.; Gelfand, M.; Atreya, C.; Miranker, A. D. (2001-06-01). “Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation”. Journal of Molecular Biology 309 (2): 339–345. doi:10.1006/jmbi.2001.4661. ISSN 0022-2836. PMID 11371157.
^ “Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects”. Medical Journal, Armed Forces India 53 (4): 251–254. (October 1997). doi:10.1016/S0377-1237(17)30746-3. PMC 5531080. PMID 28769505.
^ Pignone M, Nicoll D; McPhee SJ (2004). Pocket guide to diagnostic tests (4th ed.). New York: McGraw-Hill. pp. 191. ISBN 0-07-141184-4
^ “Chapter 111: Plasma Cell Disorders”. Harrison's Principles of Internal Medicine (18th ed.). McGraw-Hill Professional. (2011). pp. 936–44. ISBN 978-0-07-174889-6
^ “MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management”. Hematology. American Society of Hematology. Education Program 2005: 340–5. (2005). doi:10.1182/asheducation-2005.1.340. PMID 16304401.
^ “Serum levels of beta 2 microglobulin and interleukin-6 to differentiate monoclonal gammopathy of undetermined significance”. Blood 80 (9): 2433–4. (November 1992). doi:10.1182/blood.V80.9.2433.2433. PMID 1421418.

[前の解説]

[続きの解説]

「β2-ミクログロブリン」の続きの解説一覧

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166710、ENSG00000273686 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060802 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[entrez_567-5] “Entrez Gene: Beta-2-microglobulin”. 2023年1月22日閲覧。

[pmid3312414-6] “The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit”. Journal of Immunology 139 (9): 3132–8. (November 1987). PMID 3312414.

[pmid4586824-7] “The complete amino acid sequence of beta 2-microglobulin”. Biochemistry 12 (24): 4811–22. (November 1973). doi:10.1021/bi00748a001. PMID 4586824.

[pmid6171820-8] “Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin”. Proceedings of the National Academy of Sciences of the United States of America 78 (11): 6613–7. (November 1981). Bibcode: 1981PNAS...78.6613S. doi:10.1073/pnas.78.11.6613. PMC 349099. PMID 6171820.

[9] Singh, Ram Raj; Yang, Jun-Qi; Kim, Peter J.; Halder, Ramesh C. (2013-03-27). “Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus”. Arthritis Research & Therapy 15 (2): R47. doi:10.1186/ar4206. ISSN 1478-6362. PMC 3672782. PMID 23531237.

[:0-10] “Chapter 3: Iron, Heme, and Hemoglobin”. Hematology: A Pathophysiologic Approach (1st ed.). (2011). pp. 17–25. ISBN 978-0-323-04311-3

[11] Val, M.; Hengel, H.; Häcker, H.; Hartlaub, U.; Ruppert, T.; Lucin, P.; Koszinowski, U. H. (1992-09-01). “Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment”. The Journal of Experimental Medicine 176 (3): 729–738. doi:10.1084/jem.176.3.729. ISSN 0022-1007. PMC 2119349. PMID 1324970.

[12] Zijlstra, M.; Bix, M.; Simister, N. E.; Loring, J. M.; Raulet, D. H.; Jaenisch, R. (1990-04-19). “Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells”. Nature 344 (6268): 742–746. doi:10.1038/344742a0. ISSN 0028-0836. PMID 2139497.

[13] Morgan, C. J.; Gelfand, M.; Atreya, C.; Miranker, A. D. (2001-06-01). “Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation”. Journal of Molecular Biology 309 (2): 339–345. doi:10.1006/jmbi.2001.4661. ISSN 0022-2836. PMID 11371157.

[:1-14] “Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects”. Medical Journal, Armed Forces India 53 (4): 251–254. (October 1997). doi:10.1016/S0377-1237(17)30746-3. PMC 5531080. PMID 28769505.

[isbn0-07-141184-4-15] Pignone M, Nicoll D; McPhee SJ (2004). Pocket guide to diagnostic tests (4th ed.). New York: McGraw-Hill. pp. 191. ISBN 0-07-141184-4

[isbn0-07-174889-X-16] “Chapter 111: Plasma Cell Disorders”. Harrison's Principles of Internal Medicine (18th ed.). McGraw-Hill Professional. (2011). pp. 936–44. ISBN 978-0-07-174889-6

[:2-17] “MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management”. Hematology. American Society of Hematology. Education Program 2005: 340–5. (2005). doi:10.1182/asheducation-2005.1.340. PMID 16304401.

[:3-18] “Serum levels of beta 2 microglobulin and interleukin-6 to differentiate monoclonal gammopathy of undetermined significance”. Blood 80 (9): 2433–4. (November 1992). doi:10.1182/blood.V80.9.2433.2433. PMID 1421418.

[1]

[2]

[3]

[4]

β2-ミクログロブリン β2-ミクログロブリンの概要

β2-ミクログロブリン

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