ビタミンＫ２
| 分子式： | C41H56O2 |
| その他の名称： | メナキノン6、ビタミンK2、メナキノンK6、ビタミンK2(30)、Vitamin K2、Menaquinone-6、Menaquinone-K6、Vitamin K2(30)、2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexenyl]-3-methyl-1,4-naphthalenedione、ファルノキノン、Farnoquinone、ビタミンMK6、Vitamin MK6、メナキノン-6、Menaquinone 6 |
| 体系名： | 2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-ヘキサメチル-2,6,10,14,18,22-テトラコサヘキサエニル]-3-メチル-1,4-ナフタレンジオン |
ビタミンK
(ビタミンK2 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/11/10 07:41 UTC 版)
ビタミンK (Vitamin K) は、脂溶性ビタミンの一種である。ビタミンK依存性タンパク質の活性化に必須であり、動物体内で血液の凝固や組織の石灰化に関わっている。したがって欠乏すると出血傾向となり、また骨粗鬆症や動脈硬化に関連していると考えられている。化学構造上は2-メチル-1,4-ナフトキノンの3位誘導体で、天然にはK1とK2の2種類があり、このうちK2にはイソプレノイド側鎖の長さや修飾が異なる多数の化合物が含まれる。
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- ^ “Safety assessment of menaquinone-7 for use in human nutrition”. Journal of Food and Drug Analysis 23 (1). (2015). doi:10.1016/j.jfda.2014.03.001. PMID 28911451.
- ^ “Metabolism and cell biology of vitamin K”. Thrombosis and haemostasis 100 (4). (2008). doi:10.1160/TH08-03-0147. PMID 18841274.
- ^ “Conversion of phylloquinone (Vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice”. The Journal of biological chemistry 283 (17). (2008). doi:10.1074/jbc.M702971200. PMID 18083713.
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- ^ 飼料及び飼料添加物の成分規格等に関する省令 - e-Gov法令検索
- ^ 日本化学物質辞書 J10.610K参照
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- ^ “Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates”. J. Biol. Chem. 283 (52): 36655–64. (December 2008). doi:10.1074/jbc.M802761200. PMC 2605998. PMID 18836183.
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- ^ Kulman JD, Harris JE, Xie L, Davie EW (2007). “Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein”. Proc. Natl. Acad. Sci. U.S.A. 104 (21): 8767–72. doi:10.1073/pnas.0703195104. PMC 1885577. PMID 17502622.
- ^ 新生児に対するビタミンKの予防投与役に立つ医薬品情報]
- ^ Booth et al.Dietary phylloquinone depletion and repletion in older women. J. Nutr., 133, 2565-2569 (2003)
- ^ M. Kaneki et al (2001). “Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk”. Nutrition 17 (4): 315-321. doi:10.1016/S0899-9007(00)00554-2. PMID 11369171.
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- ^ Amizuka et al Clinical Calcium 19, 1788-1796
- ^ Vitamin K2: Are You Consuming Enough? on March 22, 2017 by Chris Kresser
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- ^ Luo G. et al. Sponataneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature, 386, 78-81 (1997)
- ^ Geleijnse J.M. et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J. Nutr. 134, 3100-3105 (2004)
- ^ “Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study”. The Journal of nutrition 134 (11). (2004). doi:10.1093/jn/134.11.3100. PMID 15514282.
- ^ “High dietary menaquinone intake is associated with reduced coronary calcification”. Atherosclerosis 203 (2). (2009). doi:10.1016/j.atherosclerosis.2008.07.010. PMID 18722618.
- ^ L.A. Braam et al. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb. Haemost, 91, 373-380 (2004)
- ^ “Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults”. The Journal of Clinical Endocrinology & Metabolism 100 (6). (2015). doi:10.1210/jc.2014-4449. PMID 25835288.
- ^ “Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review”. Nutrition (Burbank, Los Angeles County, Calif.) 32 (7-8). (2016). doi:10.1016/j.nut.2016.01.011. PMID 27133809.
- ^ “Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial”. JAMA ophthalmology 135 (6). (2017). doi:10.1001/jamaophthalmol.2017.1076. PMC 5847084. PMID 28494067.
- ^ “Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease”. Journal of the American Dietetic Association 108 (12). (2008). doi:10.1016/j.jada.2008.09.013. PMID 19027415.
- ^ “Phylloquinone in gingival crevicular fluid in adult periodontitis”. Journal of clinical periodontology 25 (8). (1998). doi:10.1111/j.1600-051X.1998.tb02503.x. PMID 9722271.
- ^ “Vitamin K-induced effects on body fat and weight: results from a 3-year vitamin K2 intervention study”. European journal of clinical nutrition 72 (1). (2018). doi:10.1038/ejcn.2017.146. PMID 28952607.
- ^ “Topical vitamin K1 promotes repair of full thickness wound in rat”. Indian journal of pharmacology 46 (4). (2014). doi:10.4103/0253-7613.135953. PMC 4118534. PMID 25097279.
- ^ “Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain”. The Journal of nutrition 134 (1). (2004). doi:10.1093/jn/134.1.167. PMID 14704312.
- ^ “Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study”. American journal of epidemiology 167 (3). (2008). doi:10.1093/aje/kwm306. PMC 3151653. PMID 18006902.
- ^ Hemmati AA, Houshmand G, Ghorbanzadeh B, Nemati M, Behmanesh MA (2014). “Topical vitamin K1 promotes repair of full thickness wound in rat”. Indian J Pharmacol (4): 409–12. doi:10.4103/0253-7613.135953. PMC 4118534. PMID 25097279.
- ^ Elson ML, Nacht S (1999-12). “Treatment of a periorbital hyperpigmentation with topical vitamin K/vitamin A”. Cosmet Dermatol 1999 (12): 32-34.
- ^ 日本人の食事摂取基準 (2010年版 ed.), 厚生労働省, (平成21年5月29日)]
- ^ 『表:ビタミンKの食事摂取基準（㎍/日）』（pdf）（レポート）（2010年版）厚生労働省。
- ^ 『日本人の食事摂取基準（2015 年版）の概要』（pdf）（レポート）（2015年版）厚生労働省、「日本人の食事摂取基準（2015年版）策定検討会」の報告書を取りまとめました、平成26-08-21。
- ^ 骨粗鬆症の予防と治療ガイドライン2011年版
- ^ 独立行政法人国立健康・栄養研究所監『基礎栄養学 改訂第2版』南江堂、2005年10月。ISBN 978-4-524-24206-1。184頁
- ^ B.H. Will & J.W. Suttie. J. Nutr. (1992) 122, 953-958.
- ^ J.W. Suttie et al. Vitamin K deficiency from dietary vitamin K restriction in humans. Am. J. Clin. Nutr.,47, 475-480 (1988)
- ^ G. Ferland et al. Dietary induced subclinical vitamin K deficiency in normal human subjects. J. Clin. Invest. 91, 1761-1768 (1993)
- ^ 出版物と資料、公益財団法人 骨粗鬆症財団、閲覧2017年11月30日
- ^ a b c d Vitamin K content of foods and dietary vitamin K intake in Japanese young women. 53. (2007). doi:10.3177/jnsv.53.464. PMID 18202532.
- ^ 「納豆菌による微量生理活性物質の生産」『愛知県産業技術研究所研究報告』第2号、2003年12月、132-133頁、NAID 80016376264。
- ^ 納豆非摂取群では大豆製品からの摂取は少ないことから納豆からの摂取が大きいと推定される
- ^ ワルファリンと納豆などのビタミンK含有食品 熊本県薬剤師会
- ^ Gijsbers et al,Effect of food composition on vitamin K absorption in human volunteers. Br. J. Nutr. 76, 223-229 (1996)
- ^ A.K. Garber et al. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.J. Nutr. 129, 1201-1203 (1999)
- ^ Schurgers L.J. et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood, 109, 3279–3283 (2007)
- ^ Sato T. et al. (2012). “Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women”. Nutrition journal 11 (93). doi:10.1186/1475-2891-11-93. PMC 3502319. PMID 23140417.
- ^ The British journal of nutrition 75 (1). (1996). doi:10.1079/BJN19960115. PMID 8785182.
- ^ 白幡 聡 (1990). “肝組織中のビタミンK同族体の分布とその役割”. ビタミン 64 (5-6): 341. doi:10.20632/vso.64.5-6_340.
- ^ Schurgers, LJ. et al. Oral anticoagulant treatment: friend or foe in cardiovasculare disease? Blood 104, 3231-3232 (2004)
- ^ Rennenberg, R.J. et al. Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood, 115, 5121-5123 (2010)
- ^ Vitamin K Antagonists and Cognitive Impairment: Results From a Cross-Sectional Pilot Study Among Geriatric Patients. 70. (2015). doi:10.1093/gerona/glu133. PMID 25151653.
- ^ PHYTONADIONE(TOXNET)
- ^ 日本人の食事摂取基準(2010年版)
- ^ Dam, H. (1935). “The Antihæmorrhagic Vitamin of the Chick.: Occurrence And Chemical Nature”. Nature 135 (3417): 652–653. doi:10.1038/135652b0.
- ^ MacCorquodale, D. W.; Binkley, S. B.; Thayer, S. A.; Doisy, E. A. (1939). “On the constitution of Vitamin K1”. Journal of the American Chemical Society 61 (7): 1928–1929. doi:10.1021/ja01876a510.
[続きの解説]
ビタミンK2と同じ種類の言葉
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