O-GlcNAcアーゼ O-GlcNAcアーゼの概要

OGA
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	2YDQ
識別子
記号	OGA, MEA5, NCOAT, meningioma expressed antigen 5 (hyaluronidase), MGEA5, O-GlcNAcase
外部ID	OMIM: 604039 MGI: 1932139 HomoloGene: 8154 GeneCards: OGA
遺伝子の位置 (ヒト)
染色体	10番染色体 (ヒト)
終点	101,818,465 bp
遺伝子の位置 (マウス)
染色体	19番染色体 (マウス)
終点	45,772,276 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• hyalurononglucosaminidase activity; • beta-N-acetylglucosaminidase activity; • 加水分解酵素活性; • hydrolase activity, acting on glycosyl bonds; • [protein-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity]; • [protein-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity]; • [protein-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity];
細胞の構成要素	• 細胞質; • 細胞質基質; • 膜; • 細胞核;
生物学的プロセス	• 代謝; • protein deglycosylation; • N-acetylglucosamine metabolic process; • 糖タンパク質異化プロセス; • protein O-linked glycosylation; • 糖タンパク質代謝プロセス; • viral process;
	出典:Amigo / QuickGO
オルソログ
	10724
	76055
	ENSG00000198408
	ENSMUSG00000025220
	O60502
	Q9EQQ9
	NM_001142434; NM_012215
	NM_023799
	NP_001135906; NP_036347
	NP_076288
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

[protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-serine + H₂O [protein]-L-serine + N-acetyl-D-glucosamine
[protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-threonine + H₂O [protein]-L-threonine + N-acetyl-D-glucosamine

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198408 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025220 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase”. The Journal of Biological Chemistry 277 (3): 1755–61. (January 2002). doi:10.1074/jbc.M109656200. PMID 11788610.
^ “Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants”. Biochemistry 45 (11): 3835–44. (March 2006). doi:10.1021/bi052370b. PMID 16533067. http://summit.sfu.ca/item/20441.
^ “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.
^ “Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate”. Carbohydrate Research 341 (8): 971–82. (June 2006). doi:10.1016/j.carres.2006.03.004. PMC 10561171. PMID 16584714. https://zenodo.org/record/1258816.
^ “Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol”. The Journal of Biological Chemistry 269 (30): 19321–30. (July 1994). doi:10.1016/S0021-9258(17)32170-1. PMID 8034696.
^ “Short O-GlcNAcase is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level”. Cells 11 (11): 1827. (June 2022). doi:10.3390/cells11111827. PMC 9180253. PMID 35681522.
^ “Isoforms of human O-GlcNAcase show distinct catalytic efficiencies”. Biochemistry. Biokhimiia 75 (7): 938–43. (July 2010). doi:10.1134/S0006297910070175. PMID 20673219.
^ “Glycoside Hydrolase Family 84”. Cazypedia. 2017年3月28日閲覧。
^ “Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain”. The Journal of Biological Chemistry 276 (13): 9838–45. (March 2001). doi:10.1074/jbc.M010420200. PMID 11148210.
^ “O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension”. Journal of the American Society of Hypertension 3 (6): 374–87. (2009). doi:10.1016/j.jash.2009.09.004. PMC 3022480. PMID 20409980.
^ “Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain”. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842 (9): 1333–9. (September 2014). doi:10.1016/j.bbadis.2014.05.014. PMC 4140188. PMID 24859566.
^ “The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny”. Proceedings of the National Academy of Sciences of the United States of America 97 (11): 5735–9. (May 2000). Bibcode: 2000PNAS...97.5735S. doi:10.1073/pnas.100471497. PMC 18502. PMID 10801981.
^ “Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity”. Proceedings of the National Academy of Sciences of the United States of America 107 (16): 7413–8. (April 2010). Bibcode: 2010PNAS..107.7413L. doi:10.1073/pnas.0911857107. PMC 2867743. PMID 20368426.
^ “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.
^ “O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?”. The Journal of Biological Chemistry 289 (50): 34433–9. (December 2014). doi:10.1074/jbc.R114.609198. PMC 4263850. PMID 25336650.
^ “Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors”. International Journal of Molecular Sciences 16 (9): 20212–24. (August 2015). doi:10.3390/ijms160920212. PMC 4613198. PMID 26343633.
^ “Structural and functional insight into human O-GlcNAcase”. Nature Chemical Biology 13 (6): 610–612. (June 2017). doi:10.1038/nchembio.2358. PMC 5438047. PMID 28346405.

[前の解説]

[続きの解説]

「O-GlcNAcアーゼ」の続きの解説一覧

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198408 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025220 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[5] “Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase”. The Journal of Biological Chemistry 277 (3): 1755–61. (January 2002). doi:10.1074/jbc.M109656200. PMID 11788610.

[6] “Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants”. Biochemistry 45 (11): 3835–44. (March 2006). doi:10.1021/bi052370b. PMID 16533067. http://summit.sfu.ca/item/20441.

[7] “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.

[8] “Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate”. Carbohydrate Research 341 (8): 971–82. (June 2006). doi:10.1016/j.carres.2006.03.004. PMC 10561171. PMID 16584714. https://zenodo.org/record/1258816.

[9] “Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol”. The Journal of Biological Chemistry 269 (30): 19321–30. (July 1994). doi:10.1016/S0021-9258(17)32170-1. PMID 8034696.

[10] “Short O-GlcNAcase is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level”. Cells 11 (11): 1827. (June 2022). doi:10.3390/cells11111827. PMC 9180253. PMID 35681522.

[11] “Isoforms of human O-GlcNAcase show distinct catalytic efficiencies”. Biochemistry. Biokhimiia 75 (7): 938–43. (July 2010). doi:10.1134/S0006297910070175. PMID 20673219.

[12] “Glycoside Hydrolase Family 84”. Cazypedia. 2017年3月28日閲覧。

[13] “Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain”. The Journal of Biological Chemistry 276 (13): 9838–45. (March 2001). doi:10.1074/jbc.M010420200. PMID 11148210.

[14] “O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension”. Journal of the American Society of Hypertension 3 (6): 374–87. (2009). doi:10.1016/j.jash.2009.09.004. PMC 3022480. PMID 20409980.

[15] “Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain”. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842 (9): 1333–9. (September 2014). doi:10.1016/j.bbadis.2014.05.014. PMC 4140188. PMID 24859566.

[16] “The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny”. Proceedings of the National Academy of Sciences of the United States of America 97 (11): 5735–9. (May 2000). Bibcode: 2000PNAS...97.5735S. doi:10.1073/pnas.100471497. PMC 18502. PMID 10801981.

[17] “Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity”. Proceedings of the National Academy of Sciences of the United States of America 107 (16): 7413–8. (April 2010). Bibcode: 2010PNAS..107.7413L. doi:10.1073/pnas.0911857107. PMC 2867743. PMID 20368426.

[18] “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.

[19] “O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?”. The Journal of Biological Chemistry 289 (50): 34433–9. (December 2014). doi:10.1074/jbc.R114.609198. PMC 4263850. PMID 25336650.

[20] “Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors”. International Journal of Molecular Sciences 16 (9): 20212–24. (August 2015). doi:10.3390/ijms160920212. PMC 4613198. PMID 26343633.

[21] “Structural and functional insight into human O-GlcNAcase”. Nature Chemical Biology 13 (6): 610–612. (June 2017). doi:10.1038/nchembio.2358. PMC 5438047. PMID 28346405.

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O-GlcNAcアーゼ O-GlcNAcアーゼの概要

O-GlcNAcアーゼ

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