O-GlcNAcアーゼ
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/04/09 10:26 UTC 版)
O-GlcNAcアーゼ(英: O-GlcNAcase、OGA、EC 3.2.1.169)またはMGEA5(meningioma expressed antigen 5)は、系統名が(protein)-3-O-(N-acetyl-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolaseである酵素であり、OGA遺伝子にコードされる[5][6][7][8][9] 。この酵素は次の化学反応を触媒し、O-GlcNAc化翻訳後修飾を除去する。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198408 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025220 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase”. The Journal of Biological Chemistry 277 (3): 1755–61. (January 2002). doi:10.1074/jbc.M109656200. PMID 11788610.
- ^ “Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants”. Biochemistry 45 (11): 3835–44. (March 2006). doi:10.1021/bi052370b. PMID 16533067 .
- ^ “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.
- ^ “Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate”. Carbohydrate Research 341 (8): 971–82. (June 2006). doi:10.1016/j.carres.2006.03.004. PMC 10561171. PMID 16584714 .
- ^ “Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol”. The Journal of Biological Chemistry 269 (30): 19321–30. (July 1994). doi:10.1016/S0021-9258(17)32170-1. PMID 8034696.
- ^ “Short O-GlcNAcase is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level”. Cells 11 (11): 1827. (June 2022). doi:10.3390/cells11111827. PMC 9180253. PMID 35681522 .
- ^ “Isoforms of human O-GlcNAcase show distinct catalytic efficiencies”. Biochemistry. Biokhimiia 75 (7): 938–43. (July 2010). doi:10.1134/S0006297910070175. PMID 20673219.
- ^ “Glycoside Hydrolase Family 84”. Cazypedia. 2017年3月28日閲覧。
- ^ “Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain”. The Journal of Biological Chemistry 276 (13): 9838–45. (March 2001). doi:10.1074/jbc.M010420200. PMID 11148210.
- ^ “O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension”. Journal of the American Society of Hypertension 3 (6): 374–87. (2009). doi:10.1016/j.jash.2009.09.004. PMC 3022480. PMID 20409980 .
- ^ “Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain”. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842 (9): 1333–9. (September 2014). doi:10.1016/j.bbadis.2014.05.014. PMC 4140188. PMID 24859566 .
- ^ “The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny”. Proceedings of the National Academy of Sciences of the United States of America 97 (11): 5735–9. (May 2000). Bibcode: 2000PNAS...97.5735S. doi:10.1073/pnas.100471497. PMC 18502. PMID 10801981 .
- ^ “Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity”. Proceedings of the National Academy of Sciences of the United States of America 107 (16): 7413–8. (April 2010). Bibcode: 2010PNAS..107.7413L. doi:10.1073/pnas.0911857107. PMC 2867743. PMID 20368426 .
- ^ “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.
- ^ “O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?”. The Journal of Biological Chemistry 289 (50): 34433–9. (December 2014). doi:10.1074/jbc.R114.609198. PMC 4263850. PMID 25336650 .
- ^ “Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors”. International Journal of Molecular Sciences 16 (9): 20212–24. (August 2015). doi:10.3390/ijms160920212. PMC 4613198. PMID 26343633 .
- ^ “Structural and functional insight into human O-GlcNAcase”. Nature Chemical Biology 13 (6): 610–612. (June 2017). doi:10.1038/nchembio.2358. PMC 5438047. PMID 28346405 .
- 1 O-GlcNAcアーゼとは
- 2 O-GlcNAcアーゼの概要
- 3 シノニム
- 4 構造
- 5 外部リンク
- O-GlcNAcアーゼのページへのリンク