O-GlcNAcアーゼ
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/04/09 10:26 UTC 版)
構造
さまざまなOGAタンパク質に関して、X線結晶構造が得られている。Thiamet-Gと複合体を形成したヒトOGAの構造からは、酵素阻害の構造的基盤が明らかにされている[21]。
関連文献
- “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Research 9 (3): 99–106. (June 2002). doi:10.1093/dnares/9.3.99. PMID 12168954.
- “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Research 5 (3): 169–76. (June 1998). doi:10.1093/dnares/5.3.169. PMID 9734811.
- “Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain”. The Journal of Biological Chemistry 276 (13): 9838–45. (March 2001). doi:10.1074/jbc.M010420200. PMID 11148210.
- “Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase”. Biochemical and Biophysical Research Communications 283 (3): 634–40. (May 2001). doi:10.1006/bbrc.2001.4815. PMID 11341771.
- “Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase”. The Journal of Biological Chemistry 277 (3): 1755–61. (January 2002). doi:10.1074/jbc.M109656200. PMID 11788610.
- “Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians”. Molecular Genetics and Metabolism 77 (1–2): 189–93. (2003). doi:10.1016/S1096-7192(02)00127-0. PMID 12359146 .
- “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. (August 2004). Bibcode: 2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935 .
- “Phosphoproteomic analysis of the developing mouse brain”. Molecular & Cellular Proteomics 3 (11): 1093–101. (November 2004). doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- “Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities”. The Journal of Biological Chemistry 279 (51): 53665–73. (December 2004). doi:10.1074/jbc.M410406200. PMID 15485860.
- “Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development”. Glycobiology 16 (6): 551–63. (June 2006). doi:10.1093/glycob/cwj096. PMID 16505006.
- “Location and characterization of the O-GlcNAcase active site”. Biochimica et Biophysica Acta (BBA) - General Subjects 1760 (5): 829–39. (May 2006). doi:10.1016/j.bbagen.2006.01.017. PMID 16517082.
- “MGEA5-14 polymorphism and type 2 diabetes in Mexico City”. American Journal of Human Biology 19 (4): 593–6. (2007). doi:10.1002/ajhb.20639. PMID 17546623.
関連項目
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198408 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025220 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase”. The Journal of Biological Chemistry 277 (3): 1755–61. (January 2002). doi:10.1074/jbc.M109656200. PMID 11788610.
- ^ “Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants”. Biochemistry 45 (11): 3835–44. (March 2006). doi:10.1021/bi052370b. PMID 16533067 .
- ^ “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.
- ^ “Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate”. Carbohydrate Research 341 (8): 971–82. (June 2006). doi:10.1016/j.carres.2006.03.004. PMC 10561171. PMID 16584714 .
- ^ “Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol”. The Journal of Biological Chemistry 269 (30): 19321–30. (July 1994). doi:10.1016/S0021-9258(17)32170-1. PMID 8034696.
- ^ “Short O-GlcNAcase is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level”. Cells 11 (11): 1827. (June 2022). doi:10.3390/cells11111827. PMC 9180253. PMID 35681522 .
- ^ “Isoforms of human O-GlcNAcase show distinct catalytic efficiencies”. Biochemistry. Biokhimiia 75 (7): 938–43. (July 2010). doi:10.1134/S0006297910070175. PMID 20673219.
- ^ “Glycoside Hydrolase Family 84”. Cazypedia. 2017年3月28日閲覧。
- ^ “Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain”. The Journal of Biological Chemistry 276 (13): 9838–45. (March 2001). doi:10.1074/jbc.M010420200. PMID 11148210.
- ^ “O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension”. Journal of the American Society of Hypertension 3 (6): 374–87. (2009). doi:10.1016/j.jash.2009.09.004. PMC 3022480. PMID 20409980 .
- ^ “Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain”. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842 (9): 1333–9. (September 2014). doi:10.1016/j.bbadis.2014.05.014. PMC 4140188. PMID 24859566 .
- ^ “The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny”. Proceedings of the National Academy of Sciences of the United States of America 97 (11): 5735–9. (May 2000). Bibcode: 2000PNAS...97.5735S. doi:10.1073/pnas.100471497. PMC 18502. PMID 10801981 .
- ^ “Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity”. Proceedings of the National Academy of Sciences of the United States of America 107 (16): 7413–8. (April 2010). Bibcode: 2010PNAS..107.7413L. doi:10.1073/pnas.0911857107. PMC 2867743. PMID 20368426 .
- ^ “Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity”. Nature Structural & Molecular Biology 13 (4): 365–71. (April 2006). doi:10.1038/nsmb1079. PMID 16565725.
- ^ “O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?”. The Journal of Biological Chemistry 289 (50): 34433–9. (December 2014). doi:10.1074/jbc.R114.609198. PMC 4263850. PMID 25336650 .
- ^ “Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors”. International Journal of Molecular Sciences 16 (9): 20212–24. (August 2015). doi:10.3390/ijms160920212. PMC 4613198. PMID 26343633 .
- ^ “Structural and functional insight into human O-GlcNAcase”. Nature Chemical Biology 13 (6): 610–612. (June 2017). doi:10.1038/nchembio.2358. PMC 5438047. PMID 28346405 .
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