VDAC2
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/05/25 05:01 UTC 版)
VDAC2（voltage dependent anion channel 2）は、ヒトでは10番染色体に位置するVDAC2遺伝子によってコードされるタンパク質である[5][6]。このタンパク質は電位依存性アニオンチャネル（VDAC）であり、他のVDACのアイソフォームと高い構造的相同性を有する[7][8][9]。VDACは一般的に、細胞の代謝、ミトコンドリアを介したアポトーシス、精子形成に関与している[10][11][12][13]。さらに、VDAC2は心収縮や肺循環にも関与しており、心肺疾患への関与が示唆される[10][11]。また、VDAC2は伝染性ファブリキウス嚢病（IBD）に対する免疫応答も媒介する[11]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165637 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021771 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms”. Genomics 20 (1): 62–7. (Mar 1994). doi:10.1006/geno.1994.1127. PMID 7517385.
- ^ “Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered”. Biochemical and Biophysical Research Communications 255 (3): 707–10. (Feb 1999). doi:10.1006/bbrc.1998.0136. PMID 10049775.
- ^ “Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning”. Proceedings of the National Academy of Sciences of the United States of America 95 (14): 8175–80. (Jul 1998). doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
- ^ “Isolation of a novel human voltage-dependent anion channel gene”. European Journal of Human Genetics 6 (4): 337–40. (1998). doi:10.1038/sj.ejhg.5200198. PMID 9781040.
- ^ a b “Charged residues distribution modulates selectivity of the open state of human isoforms of the voltage dependent anion-selective channel”. PLOS ONE 9 (8): e103879. (2014). doi:10.1371/journal.pone.0103879. PMC 4146382. PMID 25084457.
- ^ a b c d e “Voltage-dependent anion channel 2 modulates resting Ca²+ sparks, but not action potential-induced Ca²+ signaling in cardiac myocytes”. Cell Calcium 49 (2): 136–43. (Feb 2011). doi:10.1016/j.ceca.2010.12.004. PMID 21241999.
- ^ a b c d e f g “Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production”. American Journal of Respiratory Cell and Molecular Biology 47 (5): 669–78. (Nov 2012). doi:10.1165/rcmb.2011-0436OC. PMC 3547107. PMID 22842492.
- ^ “VDAC2 inhibits BAK activation and mitochondrial apoptosis”. Science 301 (5632): 513–7. (Jul 2003). doi:10.1126/science.1083995. PMID 12881569.
- ^ a b c d e “Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via interaction with VP5”. Journal of Virology 86 (3): 1328–38. (Feb 2012). doi:10.1128/JVI.06104-11. PMC 3264341. PMID 22114330.
- ^ “Voltage-dependent anion-selective channel (VDAC) in the plasma membrane”. FEBS Letters 584 (9): 1793–9. (May 2010). doi:10.1016/j.febslet.2010.02.049. PMID 20184885.
- ^ a b “Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway”. Molecular and Cellular Biology 24 (9): 3918–27. (May 2004). doi:10.1128/mcb.24.9.3918-3927.2004. PMC 387743. PMID 15082785.
- ^ a b “Characterization of human VDAC isoforms: a peculiar function for VDAC3?”. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797 (6–7): 1268–75. (2010). doi:10.1016/j.bbabio.2010.01.031. PMID 20138821.
- ^ “Swapping of the N-terminus of VDAC1 with VDAC3 restores full activity of the channel and confers anti-aging features to the cell”. FEBS Letters 584 (13): 2837–44. (Jul 2010). doi:10.1016/j.febslet.2010.04.066. PMID 20434446.
- ^ “VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes”. Cell Cycle 11 (19): 3666–78. (Oct 2012). doi:10.4161/cc.21927. PMC 3478317. PMID 22935710.
- ^ “VDAC3 and Mps1 negatively regulate ciliogenesis”. Cell Cycle 12 (5): 849–58. (Mar 2013). doi:10.4161/cc.23824. PMC 3610733. PMID 23388454.
- ^ “The use of anti-VDAC2 antibody for the combined assessment of human sperm acrosome integrity and ionophore A23187-induced acrosome reaction”. PLOS ONE 6 (2): e16985. (9 February 2011). doi:10.1371/journal.pone.0016985. PMC 3036732. PMID 21347391.
- ^ “Cell death: critical control points”. Cell 116 (2): 205–19. (Jan 2004). doi:10.1016/S0092-8674(04)00046-7. PMID 14744432.
- ^ “Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics”. British Journal of Cancer 26 (4): 239–57. (Aug 1972). doi:10.1038/bjc.1972.33. PMC 2008650. PMID 4561027.
- ^ “Past and present course of cardioprotection against ischemia-reperfusion injury”. Journal of Applied Physiology 103 (6): 2129–36. (Dec 2007). doi:10.1152/japplphysiol.00383.2007. PMID 17673563.
- ^ “Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy”. The Journal of Biological Chemistry 287 (48): 40652–60. (Nov 2012). doi:10.1074/jbc.M112.419721. PMC 3504778. PMID 23060438.
[続きの解説]
「VDAC2」の続きの解説一覧
- 1 VDAC2とは
- 2 VDAC2の概要
- 3 構造
- 4 相互作用
- 5 外部リンク
- vdac-2のページへのリンク
