マトリックスメタロプロテイナーゼ-9
(mmp9 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/04/14 13:46 UTC 版)
マトリックスメタロプロテイナーゼ-9（英: matrix metalloproteinase-9、略称: MMP-9）、または92 kDa IV型コラゲナーゼ（英: 92 kDa type IV collagenase）、ゼラチナーゼB（英: gelatinase B）は、細胞外マトリックスの分解に関与する亜鉛型メタロプロテイナーゼファミリーに属する酵素である。ヒトではMMP9遺伝子にコードされており[5]、シグナルペプチド、プロペプチド、3つのフィブロネクチンII型リピートが挿入された触媒ドメイン、C末端のヘモペキシン様ドメインという構成をしている[6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100985 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017737 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b “MMP9 matrix metallopeptidase 9 [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2024年4月13日閲覧。
- ^ a b “Matrix metalloproteinases”. The Journal of Biological Chemistry 274 (31): 21491–4. (July 1999). doi:10.1074/jbc.274.31.21491. PMID 10419448.
- ^ “Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage”. Brain 128 (Pt 7): 1622–33. (July 2005). doi:10.1093/brain/awh489. PMID 15800021.
- ^ “Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade”. Critical Reviews in Biochemistry and Molecular Biology 48 (3): 222–72. (2013). doi:10.3109/10409238.2013.770819. PMID 23547785.
- ^ “Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)”. Critical Reviews in Biochemistry and Molecular Biology 37 (6): 375–536. (December 2002). doi:10.1080/10409230290771546. PMID 12540195.
- ^ “A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation”. American Journal of Human Genetics 82 (5): 1122–9. (May 2008). doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130.
- ^ “Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane”. American Journal of Respiratory Cell and Molecular Biology 14 (3): 288–95. (March 1996). doi:10.1165/ajrcmb.14.3.8845180. PMID 8845180.
- ^ “Gelatinase B functions as regulator and effector in leukocyte biology”. Journal of Leukocyte Biology 69 (6): 851–9. (June 2001). doi:10.1189/jlb.69.6.851. PMID 11404367.
- ^ “Gelatinase B deficiency protects against endotoxin shock”. European Journal of Immunology 32 (8): 2163–71. (August 2002). doi:10.1002/1521-4141(200208)32:8<2163::AID-IMMU2163>3.0.CO;2-Q. PMID 12209628.
- ^ “Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas”. British Journal of Cancer 79 (11–12): 1828–35. (April 1999). doi:10.1038/sj.bjc.6690291. PMC 2362801. PMID 10206300.
- ^ “MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes”. Cell 93 (3): 411–22. (May 1998). doi:10.1016/s0092-8674(00)81169-1. PMC 2839071. PMID 9590175.
- ^ “Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand”. Cell 109 (5): 625–37. (May 2002). doi:10.1016/s0092-8674(02)00754-7. PMC 2826110. PMID 12062105.
- ^ “Gelatinase B is involved in the in vitro wound repair of human respiratory epithelium”. Journal of Cellular Physiology 166 (2): 413–26. (February 1996). doi:10.1002/(sici)1097-4652(199602)166:2<413::aid-jcp20>3.0.co;2-a. PMID 8592002.
- ^ “Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration”. The Journal of Biological Chemistry 277 (3): 2065–72. (January 2002). doi:10.1074/jbc.m107611200. PMID 11689563.
- ^ “Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels”. American Journal of Physiology. Lung Cellular and Molecular Physiology 306 (11): L1006-15. (June 2014). doi:10.1152/ajplung.00015.2014. PMC 4042193. PMID 24705725.
- ^ “Halogen bonding controls selectivity of FRET substrate probes for MMP-9”. Chemistry & Biology 21 (3): 408–13. (March 2014). doi:10.1016/j.chembiol.2014.01.008. PMID 24583051.
- ^ “Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion”. The Journal of Biological Chemistry 274 (19): 13066–76. (May 1999). doi:10.1074/jbc.274.19.13066. PMID 10224058.
- ^ “Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'”. FEBS Letters 331 (1–2): 134–40. (September 1993). doi:10.1016/0014-5793(93)80312-I. PMID 8405391.
- ^ “The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain”. Journal of Molecular Biology 264 (3): 556–66. (December 1996). doi:10.1006/jmbi.1996.0661. PMID 8969305.
- ^ “Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker”. Clinical Immunology and Immunopathology 78 (2): 161–71. (February 1996). doi:10.1006/clin.1996.0025. PMID 8625558.
- ^ “Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia”. Neuroscience Letters 238 (1–2): 53–6. (November 1997). doi:10.1016/s0304-3940(97)00859-8. PMID 9464653.
- ^ “The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer”. Folia Histochemica et Cytobiologica 50 (1): 12–9. (April 2012). doi:10.5603/fhc.2012.0002. PMID 22532131.
- ^ “The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity”. International Journal of Cancer 87 (3): 336–42. (August 2000). doi:10.1002/1097-0215(20000801)87:3<336::aid-ijc5>3.3.co;2-v. PMID 10897037.
- ^ “Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression”. Cancers 6 (1): 240–96. (January 2014). doi:10.3390/cancers6010240. PMC 3980597. PMID 24473089.
- ^ “Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer”. Cancer 76 (4): 700–8. (August 1995). doi:10.1002/1097-0142(19950815)76:4<700::aid-cncr2820760426>3.0.co;2-5. PMID 8625169.
- ^ “Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation”. The Journal of International Medical Research 42 (1): 224–30. (February 2014). doi:10.1177/0300060513488514. PMID 24345823.
- ^ “Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm”. Arteriosclerosis and Thrombosis 14 (8): 1315–20. (August 1994). doi:10.1161/01.atv.14.8.1315. PMID 8049193.
- ^ “Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms”. The Journal of Clinical Investigation 105 (11): 1641–9. (June 2000). doi:10.1172/jci8931. PMC 300851. PMID 10841523.
- ^ “Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells”. Circulation 119 (16): 2209–16. (April 2009). doi:10.1161/CIRCULATIONAHA.108.806505. PMID 19364980.
- ^ “Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria”. The American Journal of Tropical Medicine and Hygiene 93 (1): 186–8. (July 2015). doi:10.4269/ajtmh.14-0816. PMC 4497894. PMID 26013370.
- ^ Messmer, Elisabeth M.; von Lindenfels, Victoria; Garbe, Alexandra; Kampik, Anselm (November 2016). “Matrix Metalloproteinase 9 Testing in Dry Eye Disease Using a Commercially Available Point-of-Care Immunoassay”. Ophthalmology 123 (11): 2300–2308. doi:10.1016/j.ophtha.2016.07.028. PMID 27665213.
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