強迫性障害の生物学
(biology of obsessive–compulsive disorder から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2019/06/12 20:54 UTC 版)
強迫性障害(obsessive-compulsive disorder、OCD)の生物学は、強迫性障害のメカニズムに関する生物学に基づく理論を扱う。認知モデルは一般に実行機能不全または調節制御の範疇に属する[1]。神経解剖学的には機能的および構造的ニューロイメージング研究は前頭前皮質(PFC)、大脳基底核(BG)、島皮質および後帯状皮質(PCC)を関係づけており遺伝的および神経化学的研究はグルタミン酸およびモノアミン神経伝達物質を関係づけている。
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- ^ Koen, Nastassja; Stein, Dan. “Obsessive-Compulsive Disorder”. In Zigmond, M; Rowland, L; Coyle, J. Neurobiology of Brain Disorders. Elsevier. p. 628.
- ^ a b c Wood, J; Ahmari, SE (2015). “A Framework for Understanding the Emerging Role of Corticolimbic-Ventral Striatal Networks in OCD-Associated Repetitive Behaviors.”. Frontiers in Systems Neuroscience 9: 171. doi:10.3389/fnsys.2015.00171. PMC: 4681810. PMID 26733823.
- ^ Barahona-Corrêa, JB; Camacho, M; Castro-Rodrigues, P; Costa, R; Oliveira-Maia, AJ (2015). “From Thought to Action: How the Interplay Between Neuroscience and Phenomenology Changed Our Understanding of Obsessive-Compulsive Disorder.”. Frontiers in Psychology 6: 1798. doi:10.3389/fpsyg.2015.01798. PMC: 4655583. PMID 26635696.
- ^ a b Milad, MR; Rauch, SL (January 2012). “Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways.”. Trends in Cognitive Sciences 16 (1): 43–51. doi:10.1016/j.tics.2011.11.003. PMC: 4955838. PMID 22138231.
- ^ Gillan, CM; Sahakian, BJ (January 2015). “Which is the driver, the obsessions or the compulsions, in OCD?”. Neuropsychopharmacology 40 (1): 247–8. doi:10.1038/npp.2014.201. PMC: 4262900. PMID 25482176.
- ^ Rotge, Jean-Yves; Guehl, Dominique; Dilharreguy, Bixente; Cuny, Emmanuel; Tignol, Jean; Bioulac, Bernard; Allard, Michele; Burbaud, Pierre et al. (3 March 2017). “Provocation of obsessive–compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies”. Journal of Psychiatry & Neuroscience 33 (5): 405–412. ISSN 1180-4882. PMC: 2527721. PMID 18787662.
- ^ Rasgon, A; Lee, WH; Leibu, E; Laird, A; Glahn, D; Goodman, W; Frangou, S (October 2017). “Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies.”. European Psychiatry 46: 25–32. doi:10.1016/j.eurpsy.2017.08.001. PMID 28992533.
- ^ Whiteside, Stephen P.; Port, John D.; Abramowitz, Jonathan S. (2004). “A meta–analysis of functional neuroimaging in obsessive–compulsive disorder”. Psychiatry Research: Neuroimaging 132 (1): 69–79. doi:10.1016/j.pscychresns.2004.07.001. PMID 15546704.
- ^ a b c Eng, GK; Sim, K; Chen, SH (May 2015). “Meta-analytic investigations of structural grey matter, executive domain-related functional activations, and white matter diffusivity in obsessive compulsive disorder: an integrative review.”. Neuroscience and Biobehavioral Reviews 52: 233–57. doi:10.1016/j.neubiorev.2015.03.002. PMID 25766413.
- ^ Menzies, L; Chamberlain, SR; Laird, AR; Thelen, SM; Sahakian, BJ; Bullmore, ET (2008). “Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.”. Neuroscience and Biobehavioral Reviews 32 (3): 525–49. doi:10.1016/j.neubiorev.2007.09.005. PMC: 2889493. PMID 18061263.
- ^ Radua, J; Mataix-Cols, D (November 2009). “Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder.”. The British Journal of Psychiatry 195 (5): 393–402. doi:10.1192/bjp.bp.108.055046. PMID 19880927.
- ^ Rotge, JY; Guehl, D; Dilharreguy, B; Tignol, J; Bioulac, B; Allard, M; Burbaud, P; Aouizerate, B (1 January 2009). “Meta-analysis of brain volume changes in obsessive-compulsive disorder.”. Biological Psychiatry 65 (1): 75–83. doi:10.1016/j.biopsych.2008.06.019. PMID 18718575.
- ^ Radua, J; Grau, M; van den Heuvel, OA; Thiebaut de Schotten, M; Stein, DJ; Canales-Rodríguez, EJ; Catani, M; Mataix-Cols, D (June 2014). “Multimodal voxel-based meta-analysis of white matter abnormalities in obsessive-compulsive disorder.”. Neuropsychopharmacology 39 (7): 1547–57. doi:10.1038/npp.2014.5. PMC: 4023155. PMID 24407265.
- ^ Naaijen, J; Lythgoe, DJ; Amiri, H; Buitelaar, JK; Glennon, JC (May 2015). “Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: a review of magnetic resonance spectroscopy studies.”. Neuroscience and Biobehavioral Reviews 52: 74–88. doi:10.1016/j.neubiorev.2015.02.009. PMID 25712432.
- ^ Pittenger, C; Bloch, MH; Williams, K (December 2011). “Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment.”. Pharmacology & Therapeutics 132 (3): 314–32. doi:10.1016/j.pharmthera.2011.09.006. PMC: 3205262. PMID 21963369.
- ^ Wu, K; Hanna, GL; Rosenberg, DR; Arnold, PD (February 2012). “The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder.”. Pharmacology Biochemistry and Behavior 100 (4): 726–35. doi:10.1016/j.pbb.2011.10.007. PMC: 3437220. PMID 22024159.
- ^ Jacobs, edited by Christian P. Müller, Barry (2009). Handbook of the behavioral neurobiology of serotonin (1st ed.). London: Academic. pp. 549–552. ISBN 978-0-12-374634-4.
- ^ Boon, Wah Chin; Horne, Malcolm K. (2011). “Aromatase and its inhibition in behaviour, obsessive compulsive disorder and parkinsonism”. Steroids 76 (8): 816–9. doi:10.1016/j.steroids.2011.02.031. PMID 21477611.
- ^ Lochner, Christine; Hemmings, Sian M.J.; Kinnear, Craig J.; Moolman-Smook, Johanna C.; Corfield, Valerie A.; Knowles, James A.; Niehaus, Dana J.H.; Stein, Dan J. (2004). “Gender in obsessive–compulsive disorder: Clinical and genetic findings”. European Neuropsychopharmacology 14 (2): 105–13. doi:10.1016/s0924-977x(03)00063-4. PMID 15013025.
- ^ Brandes, M.; Soares, C. N.; Cohen, L. S. (2004). “Postpartum onset obsessive-compulsive disorder: Diagnosis and management”. Archives of Women's Mental Health 7 (2): 99–110. doi:10.1007/s00737-003-0035-3. PMID 15083345.
[続きの解説]
「強迫性障害の生物学」の続きの解説一覧
- 1 強迫性障害の生物学とは
- 2 強迫性障害の生物学の概要
- 3 エストロゲンとOCD
- 強迫性障害の生物学のページへのリンク
