RET (タンパク質)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/10/04 05:15 UTC 版)
RETはGDNFファミリーの細胞外シグナル伝達分子を結合する受容体型チロシンキナーゼであり、ヒトではRET遺伝子にコードされる[5]。RET遺伝子の機能喪失型変異はヒルシュスプルング病の発症と関係しており[6]、機能獲得型変異は甲状腺髄様癌、多発性内分泌腺腫症2A型と2B型を含む、さまざまなタイプのがんの発症と関係している[7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165731 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030110 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Structure and chemical inhibition of the RET tyrosine kinase domain”. J. Biol. Chem. 281 (44): 33577–87. (2006). doi:10.1074/jbc.M605604200. PMID 16928683.
- ^ Martucciello, G.; Ceccherini, I.; Lerone, M.; Jasonni, V. (2000-07). “Pathogenesis of Hirschsprung's disease”. Journal of Pediatric Surgery 35 (7): 1017–1025. doi:10.1053/jpsu.2000.7763. ISSN 0022-3468. PMID 10917288.
- ^ a b “RET germline mutations identified by exome sequencing in a Chinese multiple endocrine neoplasia type 2A/familial medullary thyroid carcinoma family”. PLoS ONE 6 (5): e20353. (2011). Bibcode: 2011PLoSO...620353Q. doi:10.1371/journal.pone.0020353. PMC 3105051. PMID 21655256.
- ^ “Activation of a novel human transforming gene, ret, by DNA rearrangement.”. Cell 42 (2): 581–8. (1985). doi:10.1016/0092-8674(85)90115-1. PMID 2992805.
- ^ “Exon structure and flanking intronic sequences of the human RET proto-oncogene”. Biochem. Biophys. Res. Commun. 196 (3): 1288–1295. (1993). doi:10.1006/bbrc.1993.2392. PMID 7902707.
- ^ “Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET”. Oncogene 11 (10): 2039–2045. (1995). PMID 7478523.
- ^ a b c “RET tyrosine kinase signaling in development and cancer”. Cytokine Growth Factor Rev. 16 (4–5): 441–67. (2005). doi:10.1016/j.cytogfr.2005.05.010. PMID 15982921.
- ^ “Characterization of the ret proto-oncogene products expressed in mouse L cells”. Oncogene 8 (11): 2925–2929. (1993). PMID 8414495.
- ^ “The GDNF family ligands and receptors - implications for neural development”. Curr. Opin. Neurobiol. 10 (1): 103–10. (2000). doi:10.1016/S0959-4388(99)00048-3. PMID 10679429.
- ^ “GDNF family neurotrophic factor signaling: four masters, one servant?”. Mol. Cell. Neurosci. 13 (5): 313–25. (1999). doi:10.1006/mcne.1999.0754. PMID 10356294.
- ^ “Identification of RET autophosphorylation sites by mass spectrometry”. J. Biol. Chem. 279 (14): 14213–24. (2004). doi:10.1074/jbc.M312600200. PMID 14711813.
- ^ Online 'Mendelian Inheritance in Man' (OMIM) MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A -171400
- ^ Menicali, Elisa; Moretti, Sonia; Voce, Pasquale; Romagnoli, Serena; Avenia, Nicola; Puxeddu, Efisio (2012). “Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma”. Frontiers in Endocrinology 3: 67. doi:10.3389/fendo.2012.00067. ISSN 1664-2392. PMC 3357465. PMID 22661970.
- ^ “Role of Dok1 in cell signaling mediated by RET tyrosine kinase”. J. Biol. Chem. 277 (36): 32781–90. (September 2002). doi:10.1074/jbc.M202336200. PMID 12087092.
- ^ “Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth”. J. Biol. Chem. 279 (40): 42072–81. (October 2004). doi:10.1074/jbc.M403726200. PMID 15286081.
- ^ “Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation”. J. Cell Biol. 154 (2): 345–54. (July 2001). doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
- ^ “A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor”. Nature 387 (6634): 717–21. (June 1997). doi:10.1038/42722. PMID 9192898.
- ^ “Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions”. J. Biol. Chem. 275 (36): 27505–12. (September 2000). doi:10.1074/jbc.M000306200. PMID 10829012.
- ^ a b “The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10”. J. Biol. Chem. 270 (37): 21461–3. (September 1995). doi:10.1074/jbc.270.37.21461. PMID 7665556.
- ^ “Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7”. J. Biol. Chem. 271 (18): 10607–10. (May 1996). doi:10.1074/jbc.271.18.10607. PMID 8631863.
- ^ a b “The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins”. Oncogene 9 (6): 1661–8. (June 1994). PMID 8183561.
- ^ “Identification of Shc docking site on Ret tyrosine kinase”. Oncogene 14 (7): 773–82. (February 1997). doi:10.1038/sj.onc.1200896. PMID 9047384.
- ^ “Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells”. Mol. Cell. Biol. 24 (21): 9390–400. (November 2004). doi:10.1128/MCB.24.21.9390-9400.2004. PMC 522220. PMID 15485908.
- ^ “Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation”. Mol. Endocrinol. 17 (6): 1155–66. (June 2003). doi:10.1210/me.2002-0401. PMID 12637586.
- ^ “MEN2A-RET-induced cellular transformation by activation of STAT3”. Oncogene 20 (38): 5350–8. (August 2001). doi:10.1038/sj.onc.1204715. PMID 11536047.
[続きの解説]
「RET (タンパク質)」の続きの解説一覧
- 1 RET (タンパク質)とは
- 2 RET (タンパク質)の概要
- 3 構造
- 4 キナーゼの活性化
- 5 相互作用
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