視床下部-下垂体-甲状腺軸
(Hypothalamic–pituitary–thyroid axis から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/03/19 16:06 UTC 版)
視床下部-下垂体-甲状腺軸（Hypothalamic–pituitary–thyroid axis、HPT軸）は、視床下部・脳下垂体・甲状腺の連携によって体内の恒常性を維持するフィードバック制御機構である。神経内分泌系の一部を成し、代謝の調節やストレスへの対応を担っている。
- ^ References used in overview figure are found in image article in Commons: References.
- ^ “TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis”. Journal of Thyroid Research 2012: 1–29. (2012). doi:10.1155/2012/351864. PMC 3544290. PMID 23365787.
- ^ References used in detailed figure are found in image article in Commons: References.
- ^ Lechan, Ronald M.; Fekete, C (2004). “Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome”. Journal of Endocrinological Investigation 27 (6 Suppl): 105–19. PMID 15481810.
- ^ “Ultra short-loop feedback control of thyrotropin secretion”. Thyroid 14 (10): 825–9. (2004). doi:10.1089/thy.2004.14.825. PMID 15588378.
- ^ “Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment”. Clinical Endocrinology 81 (6): 907–15. (2014). doi:10.1111/cen.12527. PMID 24953754.
- ^ Dietrich, JW; Midgley, JE; Larisch, R; Hoermann, R (December 2015). “Of rats and men: thyroid homeostasis in rodents and human beings.”. The Lancet Diabetes & Endocrinology 3 (12): 932–933. doi:10.1016/S2213-8587(15)00421-0. PMID 26590684.
- ^ Hoermann, R; Midgley, JE; Larisch, R; Dietrich, JW (2015). “Homeostatic Control of the Thyroid-Pituitary Axis: Perspectives for Diagnosis and Treatment.”. Frontiers in Endocrinology 6: 177. doi:10.3389/fendo.2015.00177. PMC 4653296. PMID 26635726.
- ^ “Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects”. Hormone and Metabolic Research 47 (9): 674–80. (2015). doi:10.1055/s-0034-1398616. PMID 25750078.
- ^ Hoermann, R; Midgley, JEM; Dietrich, JW; Larisch, R (June 2017). “Dual control of pituitary thyroid stimulating hormone secretion by thyroxine and triiodothyronine in athyreotic patients.”. Therapeutic Advances in Endocrinology and Metabolism 8 (6): 83–95. doi:10.1177/2042018817716401. PMC 5524252. PMID 28794850.
- ^ Fliers, E; Kalsbeek, A; Boelen, A (November 2014). “Beyond the fixed setpoint of the hypothalamus-pituitary-thyroid axis.”. European Journal of Endocrinology 171 (5): R197–208. doi:10.1530/EJE-14-0285. PMID 25005935.
- ^ a b Chatzitomaris, Apostolos; Hoermann, Rudolf; Midgley, John E.; Hering, Steffen; Urban, Aline; Dietrich, Barbara; Abood, Assjana; Klein, Harald H. et al. (20 July 2017). “Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming”. Frontiers in Endocrinology 8: 163. doi:10.3389/fendo.2017.00163. PMC 5517413. PMID 28775711.
- ^ “Thyrotropin receptor autoantibodies are associated with continued thyrotropin suppression in treated euthyroid Graves' disease patients”. Journal of Clinical Endocrinology & Metabolism 88 (9): 4135–4138. (2003). doi:10.1210/jc.2003-030430. PMID 12970276.
- ^ “Complex relationship between free thyroxine and TSH in the regulation of thyroid function”. European Journal of Endocrinology 162 (6): 1123–9. (2010). doi:10.1530/EJE-10-0106. PMID 20299491.
- ^ “The relationship between serum TSH and free T4 in older people”. Journal of Clinical Pathology 65 (5): 463–5. (2012). doi:10.1136/jclinpath-2011-200433. PMID 22287691.
- ^ “Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment?”. European Journal of Endocrinology 168 (2): 271–80. (2012). doi:10.1530/EJE-12-0819. PMID 23184912.
- ^ “Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: In vivo and in silico data suggest a hierarchical model”. Journal of Clinical Pathology 66 (4): 335–42. (2013). doi:10.1136/jclinpath-2012-201213. PMID 23423518.
- ^ “Regulation of the pituitary-thyroid axis in man: Relationship of TSH concentration to concentration of free and total thyroxine in plasma”. The Journal of Clinical Endocrinology and Metabolism 27 (2): 251–5. (1967). doi:10.1210/jcem-27-2-251. PMID 4163614.
- ^ “Ghrelin affects the hypothalamus–pituitary–thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma”. European Journal of Endocrinology 162 (6): 1059–1065. (2010). doi:10.1530/EJE-10-0094.
- ^ “甲状腺機能正常症候群（euthyroid sick syndrome） - 10. 内分泌疾患と代謝性疾患” (日本語). MSDマニュアル プロフェッショナル版. 2021年9月22日閲覧。
- ^ “Nonthyroidal illness syndrome: Is it far away from Crohn's disease?”. Journal of Clinical Gastroenterology 47 (2): 153–9. (2013). doi:10.1097/MCG.0b013e318254ea8a. PMID 22874844.
- ^ a b Dietrich, J. W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis. Berlin, Germany: Logos-Verlag Berlin. ISBN 978-3-89722-850-4. OCLC 50451543. OL 24586469M. 3897228505
- ^ “The use of thyroid function tests in the diagnosis of hypopituitarism: Definition and evaluation of the TSH Index”. Clinical Endocrinology 71 (4): 529–34. (2009). doi:10.1111/j.1365-2265.2009.03534.x. PMID 19226261.
[続きの解説]
「視床下部-下垂体-甲状腺軸」の続きの解説一覧
- 1 視床下部-下垂体-甲状腺軸とは
- 2 視床下部-下垂体-甲状腺軸の概要
- 3 診断
- 視床下部-下垂体-甲状腺軸のページへのリンク
