治療標的データベース
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/06/01 16:56 UTC 版)
治療標的データベース（英: Therapeutic Target Database、TTD）は、中国浙江大学のInnovative Drug Research and Bioinformatics Group (IDRB)とシンガポール国立大学のBioinformatics and Drug Design Groupによって構築された医薬品および医療関連のリポジトリである[1]。これは、既知および探索された治療上のタンパク質や核酸の標的[2]、標的疾患[3]、経路情報[4]、およびこれらの標的に対応する薬物に関する情報を提供する[5]。標的機能、配列、立体構造、リガンド結合特性、酵素の命名法と薬物構造、治療クラス、および臨床開発状況などの詳細な知識が得られる[6]。TTDは、http://db.idrblab.net/ttd/ からログイン不要で自由にアクセスできる。
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- ^ Li, Ying Hong; Yu, Chun Yan; Li, Xiao Xu; Zhang, Peng; Tang, Jing; Yang, Qingxia; Fu, Tingting; Zhang, Xiaoyu et al. (2018-01-04). “Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics”. Nucleic Acids Research 46 (D1): D1121–D1127. doi:10.1093/nar/gkx1076. ISSN 1362-4962. PMC: 5753365. PMID 29140520.
- ^ Hughes, Diarmaid; Andersson, Dan I. (2015-08-01). “Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms”. Nature Reviews. Genetics 16 (8): 459–471. doi:10.1038/nrg3922. ISSN 1471-0064. PMID 26149714.
- ^ Iskar, Murat; Campillos, Monica; Kuhn, Michael; Jensen, Lars Juhl; van Noort, Vera; Bork, Peer (2010-09-09). “Drug-induced regulation of target expression”. PLOS Computational Biology 6 (9): e1000925. Bibcode: 2010PLSCB...6E0925I. doi:10.1371/journal.pcbi.1000925. ISSN 1553-7358. PMC: 2936514. PMID 20838579.
- ^ Fardid, Reza; Najafi, Masoud; Salajegheh, Ashkan; Kazemi, Elahe; Rezaeyan, Abolhasan (2017-01-01). “Radiation-induced non-targeted effect in vivo: Evaluation of cyclooygenase-2 and endothelin-1 gene expression in rat heart tissues”. Journal of Cancer Research and Therapeutics 13 (1): 51–55. doi:10.4103/0973-1482.203601. ISSN 1998-4138. PMID 28508833.
- ^ a b Jia, Jia; Zhu, Feng; Ma, Xiaohua; Cao, Zhiwei; Cao, Zhiwei W.; Li, Yixue; Li, Yixue X.; Chen, Yu Zong (2009-02-01). “Mechanisms of drug combinations: interaction and network perspectives”. Nature Reviews. Drug Discovery 8 (2): 111–128. doi:10.1038/nrd2683. ISSN 1474-1784. PMID 19180105.
- ^ Tao, Lin; Zhu, Feng; Xu, Feng; Chen, Zhe; Jiang, Yu Yang; Chen, Yu Zong (2015-12-01). “Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs”. Pharmacological Research 102: 123–131. doi:10.1016/j.phrs.2015.09.019. ISSN 1096-1186. PMID 26438971.
- ^ Ohlstein, E. H.; Ruffolo, R. R.; Elliott, J. D. (2000). “Drug discovery in the next millennium”. Annual Review of Pharmacology and Toxicology 40: 177–191. doi:10.1146/annurev.pharmtox.40.1.177. ISSN 0362-1642. PMID 10836132.
- ^ Edwards, Aled (2009). “Large-scale structural biology of the human proteome”. Annual Review of Biochemistry 78: 541–568. doi:10.1146/annurev.biochem.78.070907.103305. ISSN 1545-4509. PMID 19489729.
- ^ Rask-Andersen, Mathias; Masuram, Surendar; Schiöth, Helgi B. (2014). “The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication”. Annual Review of Pharmacology and Toxicology 54: 9–26. doi:10.1146/annurev-pharmtox-011613-135943. ISSN 1545-4304. PMID 24016212.
- ^ Arnold, D.; Lueza, B.; Douillard, J.-Y.; Peeters, M.; Lenz, H.-J.; Venook, A.; Heinemann, V.; Van Cutsem, E. et al. (2017-08-01). “Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials”. Annals of Oncology 28 (8): 1713–1729. doi:10.1093/annonc/mdx175. ISSN 1569-8041. PMC: 6246616. PMID 28407110.
- ^ Shaabani, Shabnam; Huizinga, Harmen P. S.; Butera, Roberto; Kouchi, Ariana; Guzik, Katarzyna; Magiera-Mularz, Katarzyna; Holak, Tad A.; Dömling, Alexander (2018-09-01). “A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018)”. Expert Opinion on Therapeutic Patents 28 (9): 665–678. doi:10.1080/13543776.2018.1512706. ISSN 1744-7674. PMC: 6323140. PMID 30107136.
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- ^ Santos, Rita; Ursu, Oleg; Gaulton, Anna; Bento, A. Patrícia; Donadi, Ramesh S.; Bologa, Cristian G.; Karlsson, Anneli; Al-Lazikani, Bissan et al. (2017-01-01). “A comprehensive map of molecular drug targets”. Nature Reviews. Drug Discovery 16 (1): 19–34. doi:10.1038/nrd.2016.230. ISSN 1474-1784. PMC: 6314433. PMID 27910877.
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[続きの解説]
「治療標的データベース」の続きの解説一覧
- 1 治療標的データベースとは
- 2 治療標的データベースの概要
- 3 TTDデータベースの統計
- 4 臨床試験と特許保護標的
- 5 外部リンク
- 治療標的データベースのページへのリンク
