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複製起点認識複合体

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/01/06 07:20 UTC 版)

複製起点認識複合体または複製開始点認識複合体（ふくせいきてん/かいしてんにんしきふくごうたい、英: origin recognition complex、略称: ORC）は、ATP依存的に複製起点に結合する、複数サブユニット（6サブユニット）からなるDNA結合複合体であり、すべての真核生物と古細菌に存在する。この複合体のサブユニットは、ORC1（英語版）、ORC2（英語版）、ORC3（英語版）、ORC4（英語版）、ORC5（英語版）、ORC6（英語版）遺伝子によってコードされている^[1]^[2]^[3]。ORCは真核生物におけるDNA複製の中心的な構成要素であり、細胞周期を通じて複製起点のクロマチンに結合したままである^[4]。

出典

^ Origin Recognition Complex - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）
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^ ^a ^b ^c “Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins”. FEMS Yeast Res. 7 (8): 1263–9. (December 2007). doi:10.1111/j.1567-1364.2007.00298.x. PMID 17825065.
^ ^a ^b “ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex”. Nature 357 (6374): 128–34. (May 1992). doi:10.1038/357128a0. PMID 1579162.
^ ^a ^b “The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing”. Cell 83 (4): 563–8. (November 1995). doi:10.1016/0092-8674(95)90096-9. PMID 7585959.
^ ^a ^b ^c “Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae”. Genes Cells 11 (6): 557–73. (June 2006). doi:10.1111/j.1365-2443.2006.00967.x. PMID 16716188.
^ “The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators”. Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2224–8. (March 1995). doi:10.1073/pnas.92.6.2224. PMC 42456. PMID 7892251.
^ “Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC”. EMBO J. 14 (11): 2631–41. (June 1995). doi:10.1002/j.1460-2075.1995.tb07261.x. PMC 398377. PMID 7781615.
^ ^a ^b “ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA”. Nat. Struct. Mol. Biol. 12 (11): 965–71. (November 2005). doi:10.1038/nsmb1002. PMC 2952294. PMID 16228006.
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^ “Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle”. Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11211–7. (September 2001). doi:10.1073/pnas.201387198. PMC 58709. PMID 11572976.
^ “Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms”. Nature 411 (6841): 1068–73. (June 2001). doi:10.1038/35082600. PMID 11429609.
^ “Disruption of mechanisms that prevent rereplication triggers a DNA damage response”. Mol. Cell. Biol. 25 (15): 6707–21. (August 2005). doi:10.1128/MCB.25.15.6707-6721.2005. PMC 1190345. PMID 16024805.
^ “Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing”. Nature 381 (6579): 251–3. (May 1996). doi:10.1038/381251a0. PMID 8622770.
^ “The origin recognition complex, SIR1, and the S phase requirement for silencing”. Science 276 (5318): 1547–51. (June 1997). doi:10.1126/science.276.5318.1547. PMID 9171055.
^ “Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex”. Cell 88 (4): 493–502. (February 1997). doi:10.1016/S0092-8674(00)81889-9. PMID 9038340.
^ “ATP bound to the origin recognition complex is important for preRC formation”. Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8361–7. (July 2001). doi:10.1073/pnas.131006898. PMC 37444. PMID 11459976.
^ “ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication”. Mol. Cell 16 (6): 967–78. (December 2004). doi:10.1016/j.molcel.2004.11.038. PMID 15610739.
^ “Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase”. Mol. Cell 21 (1): 29–39. (January 2006). doi:10.1016/j.molcel.2005.11.023. PMID 16387651.
^ “An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes”. EMBO J. 25 (21): 5150–8. (November 2006). doi:10.1038/sj.emboj.7601391. PMC 1630405. PMID 17053779.
^ ^a ^b ^c ^d Morgan, David (2007). The Cell Cycle: Principles of Control. Primers in Biology. pp. 62–75. ISBN 978-0878935086
^ Ausiannikava, Darya; Allers, Thorsten (31 January 2017). “Diversity of DNA Replication in the Archaea”. Genes 8 (2): 56. doi:10.3390/genes8020056. PMC 5333045. PMID 28146124.
^ Fernández-Cid, Alejandra (Winter 2017). “An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly”. Molecular Cell 50 (4): 577–588. doi:10.1016/j.molcel.2013.03.026. PMID 23603117.
^ Randell, John (Winter 2017). “Sequential ATP Hydrolysis by Cdc6 and ORC Directs Loading of the Mcm2-7 Helicase”. Molecular Cell 21: 29–39. doi:10.1016/j.molcel.2005.11.023. PMID 16387651.
^ Speck, Christian (Winter 2017). “ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA”. Nature Structural & Molecular Biology 12 (11): 965–971. doi:10.1038/nsmb1002. PMC 2952294. PMID 16228006.
^ Chistol, Gheorghe (Winter 2017). “Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing”. Cell 161 (3): 429–430. doi:10.1016/j.cell.2015.04.006. PMID 25910200.
^ Yuan, Zuanning; Riera, Alberto; Bai, Lin; Sun, Jingchuan; Nandi, Saikat; Spanos, Christos; Chen, Zhuo Angel; Barbon, Marta et al. (13 February 2017). “Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1”. Nature Structural & Molecular Biology 24 (3): 316–324. doi:10.1038/nsmb.3372. PMC 5503505. PMID 28191893.

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