DDIT3 DDIT3の概要

DDIT3
識別子
記号	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3, DNA damage inducible transcript 3, C/EBPzeta, AltDDIT3
外部ID	OMIM: 126337 MGI: 109247 HomoloGene: 3012 GeneCards: DDIT3
遺伝子の位置 (ヒト)
染色体	12番染色体 (ヒト)
終点	57,521,737 bp
遺伝子の位置 (マウス)
染色体	10番染色体 (マウス)
終点	127,132,157 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • cAMP response element binding protein binding; • transcription corepressor activity; • DNA-binding transcription factor activity; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 転写因子結合; • transcription cis-regulatory region binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • leucine zipper domain binding; • 血漿タンパク結合; • protein heterodimerization activity; • protein homodimerization activity; • DNA-binding transcription factor activity, RNA polymerase II-specific;
細胞の構成要素	• 細胞質; • 細胞質基質; • late endosome; • CHOP-C/EBP complex; • 核質; • transcription factor AP-1 complex; • protein-DNA complex; • CHOP-ATF4 complex; • CHOP-ATF3 complex; • 細胞核;
生物学的プロセス	• アポトーシス; • release of sequestered calcium ion into cytosol; • negative regulation of protein kinase B signaling; • negative regulation of fat cell differentiation; • negative regulation of myoblast differentiation; • regulation of transcription, DNA-templated; • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • negative regulation of DNA binding; • mRNA transcription by RNA polymerase II; • positive regulation of neuron death; • negative regulation of transcription by RNA polymerase II; • Wntシグナル経路; • cell redox homeostasis; • response to endoplasmic reticulum stress; • PERK-mediated unfolded protein response; • ER overload response; • cellular response to DNA damage stimulus; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • ATF6-mediated unfolded protein response; • positive regulation of neuron apoptotic process; • response to unfolded protein; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; • positive regulation of interleukin-8 production; • 餓死; • negative regulation of determination of dorsal identity; • 細胞周期; • regulation of DNA-templated transcription in response to stress; • negative regulation of transcription, DNA-templated; • negative regulation of canonical Wnt signaling pathway; • positive regulation of transcription by RNA polymerase II; • proteasome-mediated ubiquitin-dependent protein catabolic process; • blood vessel maturation; • negative regulation of CREB transcription factor activity; • 小胞体ストレス; • establishment of protein localization to mitochondrion; • intrinsic apoptotic signaling pathway in response to nitrosative stress; • negative regulation of DNA-binding transcription factor activity; • positive regulation of DNA-binding transcription factor activity; • protein complex oligomerization; • negative regulation of cold-induced thermogenesis; • regulation of autophagy; • positive regulation of intrinsic apoptotic signaling pathway;
	出典:Amigo / QuickGO
オルソログ
	1649
	13198
	ENSG00000175197
	ENSMUSG00000025408
	P35638
	P35639
NM_001195053; NM_001195054; NM_001195055; NM_001195056; NM_001195057;
	NM_004083
	NM_001290183; NM_007837
NP_001181982; NP_001181983; NP_001181984; NP_001181985; NP_001181986;
	NP_004074
	NP_001277112; NP_031863
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175197 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025408 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C”. Molecular and Cellular Biology 11 (2): 1009–16. (February 1991). doi:10.1128/MCB.11.2.1009. PMC 359769. PMID 1990262.
^ ^a ^b ^c “Entrez Gene: DDIT3 DNA-damage-inducible transcript 3”. 2022年9月3日閲覧。
^ “Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element”. Molecular and Cellular Biology 16 (4): 1479–89. (April 1996). doi:10.1128/MCB.16.4.1479. PMC 231132. PMID 8657121.
^ “CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription”. Genes & Development 6 (3): 439–53. (March 1992). doi:10.1101/gad.6.3.439. PMID 1547942.
^ “A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure”. Nature Communications 8 (1): 133. (July 2017). Bibcode: 2017NatCo...8..133Y. doi:10.1038/s41467-017-00171-w. PMC 5527107. PMID 28743963.
^ ^a ^b ^c “Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis”. The Journal of Cell Biology 186 (6): 783–92. (September 2009). doi:10.1083/jcb.200904060. PMC 2753154. PMID 19752026.
^ “Roles of CHOP/GADD153 in endoplasmic reticulum stress”. Cell Death and Differentiation 11 (4): 381–9. (April 2004). doi:10.1038/sj.cdd.4401373. PMID 14685163.
^ “ER stress and diseases”. The FEBS Journal 274 (3): 630–58. (February 2007). doi:10.1111/j.1742-4658.2007.05639.x. PMID 17288551.
^ “GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis”. The Journal of Pathology 239 (4): 411–25. (August 2016). doi:10.1002/path.4738. PMID 27135434.
^ “Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy”. Journal of Neurosurgery 124 (3): 687–702. (March 2016). doi:10.3171/2015.3.JNS141802. PMID 26381255.
^ “Endoplasmic reticulum stress in the pathogenesis of fibrotic disease”. The Journal of Clinical Investigation 128 (1): 64–73. (January 2018). doi:10.1172/JCI93560. PMC 5749533. PMID 29293089.
^ “The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress”. Current Molecular Medicine 16 (6): 533–44. (2016). doi:10.2174/1566524016666160523143937. PMC 5008685. PMID 27211800.
^ “ER stress-induced cell death mechanisms”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833 (12): 3460–3470. (December 2013). doi:10.1016/j.bbamcr.2013.06.028. PMC 3834229. PMID 23850759.
^ “Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways”. FASEB Journal 24 (1): 296–308. (January 2010). doi:10.1096/fj.09-135087. PMC 2797032. PMID 19723703.
^ “Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway”. Neuroscience 388: 284–296. (September 2018). doi:10.1016/j.neuroscience.2018.07.023. PMID 30036660.
^ “ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response”. Molecular and Cellular Biology 20 (18): 6755–67. (September 2000). doi:10.1128/mcb.20.18.6755-6767.2000. PMC 86199. PMID 10958673.
^ “IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates”. Cell 138 (3): 562–75. (August 2009). doi:10.1016/j.cell.2009.07.017. PMC 2762408. PMID 19665977.
^ “XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor”. Cell 107 (7): 881–91. (December 2001). doi:10.1016/s0092-8674(01)00611-0. PMID 11779464.
^ “The unfolded protein response: integrating stress signals through the stress sensor IRE1α”. Physiological Reviews 91 (4): 1219–43. (October 2011). doi:10.1152/physrev.00001.2011. hdl:10533/135654. PMID 22013210.
^ “Transcription Factor C/EBP Homologous Protein in Health and Diseases”. Frontiers in Immunology 8: 1612. (2017). doi:10.3389/fimmu.2017.01612. PMC 5712004. PMID 29230213.
^ “Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities”. Nature Reviews. Drug Discovery 7 (12): 1013–30. (December 2008). doi:10.1038/nrd2755. PMID 19043451.
^ “Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase”. Science 272 (5266): 1347–9. (May 1996). Bibcode: 1996Sci...272.1347W. doi:10.1126/science.272.5266.1347. PMID 8650547.
^ “How IRE1 reacts to ER stress”. Cell 132 (1): 24–6. (January 2008). doi:10.1016/j.cell.2007.12.017. PMID 18191217.
^ “Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice”. Cellular Physiology and Biochemistry 27 (5): 487–96. (2011). doi:10.1159/000329970. PMID 21691066.
^ ^a ^b “Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway”. Anti-Cancer Drugs 28 (1): 66–74. (January 2017). doi:10.1097/CAD.0000000000000431. PMID 27603596.
^ “UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression”. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 300 (1): R92-100. (January 2011). doi:10.1152/ajpregu.00169.2010. PMID 21068199.
^ “The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity”. Archives of Toxicology 88 (6): 1267–80. (June 2014). doi:10.1007/s00204-014-1240-8. hdl:10533/127482. PMID 24748426.
^ “CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress”. PLOS ONE 7 (6): e39586. (2012-06-28). Bibcode: 2012PLoSO...739586G. doi:10.1371/journal.pone.0039586. PMC 3386252. PMID 22761832.
^ “Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA”. The Journal of Neuroscience 30 (50): 16938–48. (December 2010). doi:10.1523/JNEUROSCI.1598-10.2010. PMC 6634926. PMID 21159964.
^ “Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element”. Molecular and Cellular Biology 16 (4): 1479–89. (April 1996). doi:10.1128/mcb.16.4.1479. PMC 231132. PMID 8657121.
^ “Cell death induced by endoplasmic reticulum stress”. The FEBS Journal 283 (14): 2640–52. (July 2016). doi:10.1111/febs.13598. PMID 26587781.
^ “The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques”. Arteriosclerosis, Thrombosis, and Vascular Biology 30 (10): 1925–32. (October 2010). doi:10.1161/ATVBAHA.110.206094. PMID 20651282.
^ “Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis”. Genes & Development 30 (19): 2133–2151. (October 2016). doi:10.1101/gad.289298.116. PMC 5088563. PMID 27798841.
^ “TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1”. American Journal of Physiology. Renal Physiology 299 (5): F965-72. (November 2010). doi:10.1152/ajprenal.00236.2010. PMC 2980398. PMID 20660016.
^ “Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma”. Lung Cancer 120: 34–45. (June 2018). doi:10.1016/j.lungcan.2018.03.022. PMID 29748013.
^ “HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4”. Cellular Signalling 26 (3): 556–63. (March 2014). doi:10.1016/j.cellsig.2013.11.026. PMID 24308964.
^ “TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death”. The EMBO Journal 24 (6): 1243–55. (March 2005). doi:10.1038/sj.emboj.7600596. PMC 556400. PMID 15775988.
^ “TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver”. Science 300 (5625): 1574–7. (June 2003). Bibcode: 2003Sci...300.1574D. doi:10.1126/science.1079817. PMID 12791994.
^ “TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells”. Oncology Letters 15 (1): 1343–1349. (January 2018). doi:10.3892/ol.2017.7361. PMC 5769383. PMID 29391905.
^ ^a ^b ^c “DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells”. The Journal of Biological Chemistry 290 (17): 11108–18. (April 2015). doi:10.1074/jbc.M115.645333. PMC 4409269. PMID 25770212.
^ “Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells”. Clinical Cancer Research 22 (16): 4145–57. (August 2016). doi:10.1158/1078-0432.CCR-15-2254. PMID 26983464.
^ “Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis”. Science 345 (6192): 98–101. (July 2014). Bibcode: 2014Sci...345...98L. doi:10.1126/science.1254312. PMC 4284148. PMID 24994655.
^ “Apoptosis: a review of programmed cell death”. Toxicologic Pathology 35 (4): 495–516. (June 2007). doi:10.1080/01926230701320337. PMC 2117903. PMID 17562483.
^ “CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum”. Genes & Development 18 (24): 3066–77. (December 2004). doi:10.1101/gad.1250704. PMC 535917. PMID 15601821.
^ ^a ^b “Fusion of the EWS and CHOP genes in myxoid liposarcoma”. Oncogene 12 (3): 489–94. (February 1996). PMID 8637704.
^ “NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis”. The Journal of Cell Biology 191 (6): 1113–25. (December 2010). doi:10.1083/jcb.201006121. PMC 3002036. PMID 21135141.
^ ^a ^b “Targeting unfolded protein response in cancer and diabetes”. Endocrine-Related Cancer 22 (3): C1-4. (June 2015). doi:10.1530/ERC-15-0106. PMID 25792543.
^ ^a ^b “GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis”. Journal of Cellular Biochemistry 117 (8): 1813–21. (August 2016). doi:10.1002/jcb.25481. PMC 4909508. PMID 26729625.
^ “Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis”. BMC Cancer 13: 96. (March 2013). doi:10.1186/1471-2407-13-96. PMC 3598994. PMID 23448667.
^ “Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10”. Molecular and Cellular Biology 16 (3): 1157–68. (March 1996). doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660.
^ ^a ^b ^c “CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins”. Molecular and Cellular Biology 19 (11): 7589–99. (November 1999). doi:10.1128/MCB.19.11.7589. PMC 84780. PMID 10523647.
^ “C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform”. FEBS Letters 541 (1–3): 33–9. (April 2003). doi:10.1016/s0014-5793(03)00283-7. PMID 12706815.
^ “Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress”. The Journal of Biological Chemistry 271 (24): 14285–9. (June 1996). doi:10.1074/jbc.271.24.14285. PMID 8662954.
^ “CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation”. The Journal of Biological Chemistry 278 (42): 40514–20. (October 2003). doi:10.1074/jbc.M306404200. PMID 12876286.
^ “Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis”. The Journal of Biological Chemistry 275 (11): 7591–6. (March 2000). doi:10.1074/jbc.275.11.7591. PMID 10713066.
^ Song, Benbo; Scheuner, Donalyn; Ron, David; Pennathur, Subramaniam; Kaufman, Randal J. (October 2008). “Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes”. The Journal of Clinical Investigation 118 (10): 3378–3389. doi:10.1172/JCI34587. ISSN 0021-9738. PMC 2528909. PMID 18776938.
^ Maris, M.; Overbergh, L.; Gysemans, C.; Waget, A.; Cardozo, A. K.; Verdrengh, E.; Cunha, J. P. M.; Gotoh, T. et al. (April 2012). “Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance” (英語). Diabetologia 55 (4): 1167–1178. doi:10.1007/s00125-011-2427-7. ISSN 0012-186X. PMID 22237685.
^ ^a ^b Yong, Jing; Parekh, Vishal S.; Reilly, Shannon M.; Nayak, Jonamani; Chen, Zhouji; Lebeaupin, Cynthia; Jang, Insook; Zhang, Jiangwei et al. (2021-07-28). “Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice”. Science Translational Medicine 13 (604). doi:10.1126/scitranslmed.aba9796. ISSN 1946-6242. PMC 8557800. PMID 34321322.
^ WO application 2017192820, Monia, Brett P.; Thazha P. Prakash & Garth A. Kinberger et al., "GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof", published 2017-11-09, assigned to Ionis Pharmaceuticals Inc. and AstraZeneca AB
^ Yong, Jing; Johnson, James D.; Arvan, Peter; Han, Jaeseok; Kaufman, Randal J. (August 2021). “Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus”. Nature Reviews. Endocrinology 17 (8): 455–467. doi:10.1038/s41574-021-00510-4. ISSN 1759-5037. PMC 8765009. PMID 34163039.
^ ^a ^b “Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells”. Viruses 8 (2): 56. (February 2016). doi:10.3390/v8020056. PMC 4776210. PMID 26907328.
^ “HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction”. Molecular Neurobiology 53 (1): 132–142. (January 2016). doi:10.1007/s12035-014-8991-3. PMC 4787264. PMID 25409632.
^ “HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathway”. Scientific Reports 6: 18929. (January 2016). Bibcode: 2016NatSR...618929S. doi:10.1038/srep18929. PMC 4703964. PMID 26740125.
^ “Upregulation of CHOP/GADD153 during coronavirus infectious bronchitis virus infection modulates apoptosis by restricting activation of the extracellular signal-regulated kinase pathway”. Journal of Virology 87 (14): 8124–34. (July 2013). doi:10.1128/JVI.00626-13. PMC 3700216. PMID 23678184.
^ “Endoplasmic reticulum stress pathway-mediated apoptosis in macrophages contributes to the survival of Mycobacterium tuberculosis”. PLOS ONE 6 (12): e28531. (2011). Bibcode: 2011PLoSO...628531L. doi:10.1371/journal.pone.0028531. PMC 3237454. PMID 22194844.
^ “Induction of ER stress in macrophages of tuberculosis granulomas”. PLOS ONE 5 (9): e12772. (September 2010). Bibcode: 2010PLoSO...512772S. doi:10.1371/journal.pone.0012772. PMC 2939897. PMID 20856677.
^ “Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis”. PLOS ONE 8 (12): e82322. (2013). Bibcode: 2013PLoSO...882322A. doi:10.1371/journal.pone.0082322. PMC 3862672. PMID 24349255.
^ “Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells”. Cellular Microbiology 10 (3): 770–80. (March 2008). doi:10.1111/j.1462-5822.2007.01083.x. PMID 18005243.
^ “Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells”. Toxins 9 (10): 319. (October 2017). doi:10.3390/toxins9100319. PMC 5666366. PMID 29027919.
^ “Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells”. Endocrinology 148 (7): 3258–70. (July 2007). doi:10.1210/en.2006-1564. PMID 17431003.
^ “C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation”. Mucosal Immunology 7 (6): 1452–66. (November 2014). doi:10.1038/mi.2014.34. PMID 24850428.

[前の解説]

[続きの解説]

「DDIT3」の続きの解説一覧

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175197 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025408 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid1990262-5] “Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C”. Molecular and Cellular Biology 11 (2): 1009–16. (February 1991). doi:10.1128/MCB.11.2.1009. PMC 359769. PMID 1990262.

[entrez-6] “Entrez Gene: DDIT3 DNA-damage-inducible transcript 3”. 2022年9月3日閲覧。

[:6-7] “Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element”. Molecular and Cellular Biology 16 (4): 1479–89. (April 1996). doi:10.1128/MCB.16.4.1479. PMC 231132. PMID 8657121.

[Ron_1992-8] “CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription”. Genes & Development 6 (3): 439–53. (March 1992). doi:10.1101/gad.6.3.439. PMID 1547942.

[Yao_2017-9] “A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure”. Nature Communications 8 (1): 133. (July 2017). Bibcode: 2017NatCo...8..133Y. doi:10.1038/s41467-017-00171-w. PMC 5527107. PMID 28743963.

[pmid19752026-10] “Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis”. The Journal of Cell Biology 186 (6): 783–92. (September 2009). doi:10.1083/jcb.200904060. PMC 2753154. PMID 19752026.

[pmid14685163-11] “Roles of CHOP/GADD153 in endoplasmic reticulum stress”. Cell Death and Differentiation 11 (4): 381–9. (April 2004). doi:10.1038/sj.cdd.4401373. PMID 14685163.

[pmid17288551-12] “ER stress and diseases”. The FEBS Journal 274 (3): 630–58. (February 2007). doi:10.1111/j.1742-4658.2007.05639.x. PMID 17288551.

[pmid27135434-13] “GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis”. The Journal of Pathology 239 (4): 411–25. (August 2016). doi:10.1002/path.4738. PMID 27135434.

[14] “Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy”. Journal of Neurosurgery 124 (3): 687–702. (March 2016). doi:10.3171/2015.3.JNS141802. PMID 26381255.

[15] “Endoplasmic reticulum stress in the pathogenesis of fibrotic disease”. The Journal of Clinical Investigation 128 (1): 64–73. (January 2018). doi:10.1172/JCI93560. PMC 5749533. PMID 29293089.

[pmid27211800-16] “The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress”. Current Molecular Medicine 16 (6): 533–44. (2016). doi:10.2174/1566524016666160523143937. PMC 5008685. PMID 27211800.

[pmid23850759-17] “ER stress-induced cell death mechanisms”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833 (12): 3460–3470. (December 2013). doi:10.1016/j.bbamcr.2013.06.028. PMC 3834229. PMID 23850759.

[:7-18] “Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways”. FASEB Journal 24 (1): 296–308. (January 2010). doi:10.1096/fj.09-135087. PMC 2797032. PMID 19723703.

[:8-19] “Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway”. Neuroscience 388: 284–296. (September 2018). doi:10.1016/j.neuroscience.2018.07.023. PMID 30036660.

[:9-20] “ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response”. Molecular and Cellular Biology 20 (18): 6755–67. (September 2000). doi:10.1128/mcb.20.18.6755-6767.2000. PMC 86199. PMID 10958673.

[:10-21] “IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates”. Cell 138 (3): 562–75. (August 2009). doi:10.1016/j.cell.2009.07.017. PMC 2762408. PMID 19665977.

[:11-22] “XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor”. Cell 107 (7): 881–91. (December 2001). doi:10.1016/s0092-8674(01)00611-0. PMID 11779464.

[:12-23] “The unfolded protein response: integrating stress signals through the stress sensor IRE1α”. Physiological Reviews 91 (4): 1219–43. (October 2011). doi:10.1152/physrev.00001.2011. hdl:10533/135654. PMID 22013210.

[:13-24] “Transcription Factor C/EBP Homologous Protein in Health and Diseases”. Frontiers in Immunology 8: 1612. (2017). doi:10.3389/fimmu.2017.01612. PMC 5712004. PMID 29230213.

[:14-25] “Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities”. Nature Reviews. Drug Discovery 7 (12): 1013–30. (December 2008). doi:10.1038/nrd2755. PMID 19043451.

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DDIT3 DDIT3の概要

DDIT3

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「DDIT3」の関連用語