プレセニリン1とは - わかりやすく解説 Weblio辞書

プレセニリン1

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/19 14:06 UTC 版)

プレセニリン1（英: presenilin-1、PS-1）は、ヒトではPSEN1遺伝子にコードされるプレセニリンタンパク質の1つである。プレセニリン1はγ-セクレターゼ複合体中の4つのコアタンパク質の1つであり、アミロイド前駆体タンパク質（APP）からアミロイドβ（Aβ）の産生に重要な役割を果たしていると考えられている。Aβの蓄積はアルツハイマー病の発症と関係している^[5]。

出典

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^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019969 - Ensembl, May 2017
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