長鎖ノンコーディングRNA
(lncRNA から転送)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/06/04 05:49 UTC 版)
長鎖ノンコーディングRNA(ちょうさノンコーディングRNA、英: long non-coding RNA、略称: lncRNA)はRNAの一種であり、一般的に、タンパク質へ翻訳されない200ヌクレオチド以上の長さの転写産物として定義される[2]。miRNA、siRNA、piRNA、snoRNAなどの短鎖ノンコーディングRNAとlncRNAとの区別は、こうした恣意的な基準によってなされている[3]。
- ^ a b “Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease”. Non-Coding RNA 5 (1): 17. (February 2019). doi:10.3390/ncrna5010017. PMC 6468922. PMID 30781588 .
- ^ “Visiting "noncodarnia"”. BioTechniques 54 (6): 301, 303–4. (June 2013). doi:10.2144/000114037. PMID 23750541. ""We're calling long noncoding RNAs a class, when actually the only definition is that they are longer than 200 bp," says Ana Marques, a Research Fellow at the University of Oxford who uses evolutionary approaches to understand lncRNA function."
- ^ “On the classification of long non-coding RNAs”. RNA Biology 10 (6): 925–933. (June 2013). doi:10.4161/rna.24604. PMC 4111732. PMID 23696037 .
- ^ Ransohoff, Julia D.; Wei, Yuning; Khavari, Paul A. (2018-03). “The functions and unique features of long intergenic non-coding RNA”. Nature Reviews. Molecular Cell Biology 19 (3): 143–157. doi:10.1038/nrm.2017.104. ISSN 1471-0080. PMC 5889127. PMID 29138516 .
- ^ Ma, Lina; Bajic, Vladimir B.; Zhang, Zhang (2013-04-15). “On the classification of long non-coding RNAs.”. RNA Biology 10 (6): 925–933. doi:10.4161/RNA.24604. PMC 4111732. PMID 23696037 .
- ^ a b “RNA maps reveal new RNA classes and a possible function for pervasive transcription”. Science 316 (5830): 1484–1488. (June 2007). Bibcode: 2007Sci...316.1484K. doi:10.1126/science.1138341. PMID 17510325 .
- ^ a b c d Carninci, P.; Kasukawa, T.; Katayama, S.; Gough, J.; Frith, M. C.; Maeda, N.; Oyama, R.; Ravasi, T. et al. (2005-09-02). “The transcriptional landscape of the mammalian genome”. Science (New York, N.Y.) 309 (5740): 1559–1563. doi:10.1126/science.1112014. ISSN 1095-9203. PMID 16141072 .
- ^ “Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution”. Science 308 (5725): 1149–1154. (May 2005). Bibcode: 2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807.
- ^ a b “The evolution of lncRNA repertoires and expression patterns in tetrapods”. Nature 505 (7485): 635–640. (January 2014). Bibcode: 2014Natur.505..635N. doi:10.1038/nature12943. PMID 24463510.
- ^ a b “The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression”. Genome Research 22 (9): 1775–1789. (September 2012). doi:10.1101/gr.132159.111. PMC 3431493. PMID 22955988 .
- ^ “An atlas of human long non-coding RNAs with accurate 5′ ends”. Nature 543 (7644): 199–204. (March 2017). Bibcode: 2017Natur.543..199H. doi:10.1038/nature21374. PMC 6857182. PMID 28241135 .
- ^ a b “Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses”. Genes & Development 25 (18): 1915–1927. (September 2011). doi:10.1101/gad.17446611. PMC 3185964. PMID 21890647 .
- ^ “Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome”. Genome Research 16 (1): 11–19. (January 2006). doi:10.1101/gr.4200206. PMC 1356124. PMID 16344565 .
- ^ “HIPSTR and thousands of lncRNAs are heterogeneously expressed in human embryos, primordial germ cells and stable cell lines”. Scientific Reports 6: 32753. (September 2016). Bibcode: 2016NatSR...632753Y. doi:10.1038/srep32753. PMC 5015059. PMID 27605307 .
- ^ “Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells”. Nature Structural & Molecular Biology 20 (9): 1131–1139. (September 2013). doi:10.1038/nsmb.2660. PMID 23934149.
- ^ “Single-cell analysis of long non-coding RNAs in the developing human neocortex”. Genome Biology 17: 67. (April 2016). doi:10.1186/s13059-016-0932-1. PMC 4831157. PMID 27081004 .
- ^ a b c d “LncBook: a curated knowledgebase of human long non-coding RNAs”. Nucleic Acids Research 47 (Database issue): D128–D134. (Jan 2019). doi:10.1093/nar/gky960. PMC 6323930. PMID 30329098 .
- ^ “GREENC: a Wiki-based database of plant lncRNAs”. Nucleic Acids Research 44 (D1): D1161–6. (January 2016). doi:10.1093/nar/gkv1215. PMC 4702861. PMID 26578586 .
- ^ “Genome-wide transcription and the implications for genomic organization”. Nature Reviews Genetics 8 (6): 413–423. (June 2007). doi:10.1038/nrg2083. PMID 17486121.
- ^ ENCODE Project Consortium; Birney, Ewan; Stamatoyannopoulos, John A.; Dutta, Anindya; Guigó, Roderic; Gingeras, Thomas R.; Margulies, Elliott H.; Weng, Zhiping et al. (2007-06-14). “Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project”. Nature 447 (7146): 799–816. doi:10.1038/nature05874. ISSN 1476-4687. PMC 2212820. PMID 17571346 .
- ^ “RNAsamba: neural network-based assessment of the protein-coding potential of RNA sequences”. NAR Genomics and Bioinformatics 2 (1): lqz024. (March 2020). doi:10.1093/nargab/lqz024. PMC 7671399. PMID 33575571 .
- ^ “Characterization and identification of long non-coding RNAs based on feature relationship”. Bioinformatics 41 (Database issue): D246–D251. (January 2019). doi:10.1093/bioinformatics/btz008. PMID 30649200.
- ^ “CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model”. Nucleic Acids Research 41 (6): e74. (April 2013). doi:10.1093/nar/gkt006. PMC 3616698. PMID 23335781 .
- ^ “COME: a robust coding potential calculation tool for lncRNA identification and characterization based on multiple features”. Nucleic Acids Research 45 (1): e2. (January 2017). doi:10.1093/nar/gkw798. PMC 5224497. PMID 27608726 .
- ^ “lncRScan-SVM: A Tool for Predicting Long Non-Coding RNAs Using Support Vector Machine”. PLOS ONE 10 (10): e0139654. (2015). Bibcode: 2015PLoSO..1039654S. doi:10.1371/journal.pone.0139654. PMC 4593643. PMID 26437338 .
- ^ a b “Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts”. Nucleic Acids Research 41 (17): e166. (September 2013). doi:10.1093/nar/gkt646. PMC 3783192. PMID 23892401 .
- ^ “FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome”. Nucleic Acids Research 45 (8): e57. (May 2017). doi:10.1093/nar/gkw1306. PMC 5416892. PMID 28053114 .
- ^ “PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions”. Bioinformatics 27 (13): i275–i282. (July 2011). doi:10.1093/bioinformatics/btr209. PMC 3117341. PMID 21685081 .
- ^ “PLIT: An alignment-free computational tool for identification of long non-coding RNAs in plant transcriptomic datasets”. Computers in Biology and Medicine 105: 169–181. (February 2019). arXiv:1902.05064. Bibcode: 2019arXiv190205064D. doi:10.1016/j.compbiomed.2018.12.014. PMID 30665012.
- ^ “Pattern recognition analysis on long noncoding RNAs: a tool for prediction in plants”. Briefings in Bioinformatics 20 (2): 682–689. (2019). doi:10.1093/bib/bby034. PMID 29697740.
- ^ “PLncPRO for prediction of long non-coding RNAs (lncRNAs) in plants and its application for discovery of abiotic stress-responsive lncRNAs in rice and chickpea”. Nucleic Acids Research 45 (22): e183. (December 2017). doi:10.1093/nar/gkx866. PMC 5727461. PMID 29036354 .
- ^ “Prediction of plant lncRNA by ensemble machine learning classifiers”. BMC Genomics 19 (1): 316. (May 2018). doi:10.1186/s12864-018-4665-2. PMC 5930664. PMID 29720103 .
- ^ “Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs”. Genome Biology 17 (19): 19. (Feb 2016). doi:10.1186/s13059-016-0880-9. PMC 4739325. PMID 26838501 .
- ^ “A micropeptide encoded by a putative long noncoding RNA regulates muscle performance”. Cell 160 (4): 595–606. (February 2015). doi:10.1016/j.cell.2015.01.009. PMC 4356254. PMID 25640239 .
- ^ “mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide”. Nature 541 (7636): 228–232. (January 2017). Bibcode: 2017Natur.541..228M. doi:10.1038/nature21034. PMID 28024296.
- ^ “Toddler: an embryonic signal that promotes cell movement via Apelin receptors”. Science 343 (6172): 1248636. (February 2014). doi:10.1126/science.1248636. PMC 4107353. PMID 24407481 .
- ^ “Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes”. Cell 147 (4): 789–802. (November 2011). doi:10.1016/j.cell.2011.10.002. PMC 3225288. PMID 22056041 .
- ^ a b “Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins”. eLife 4: e08890. (December 2015). doi:10.7554/eLife.08890. PMC 4739776. PMID 26687005 .
- ^ “Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins”. Cell 154 (1): 240–251. (July 2013). doi:10.1016/j.cell.2013.06.009. PMC 3756563. PMID 23810193 .
- ^ “Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals”. Nature 458 (7235): 223–227. (March 2009). Bibcode: 2009Natur.458..223G. doi:10.1038/nature07672. PMC 2754849. PMID 19182780 .
- ^ “Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs”. Genome Research 17 (5): 556–565. (May 2007). doi:10.1101/gr.6036807. PMC 1855172. PMID 17387145 .
- ^ “Mutations within lncRNAs are effectively selected against in fruitfly but not in human”. Genome Biology 14 (5): R49. (May 2013). doi:10.1186/gb-2013-14-5-r49. PMC 4053968. PMID 23710818 .
- ^ “Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals”. Genome Research 24 (4): 616–628. (April 2014). doi:10.1101/gr.165035.113. PMC 3975061. PMID 24429298 .
- ^ “Rapid turnover of long noncoding RNAs and the evolution of gene expression”. PLOS Genetics 8 (7): e1002841. (2012). doi:10.1371/journal.pgen.1002841. PMC 3406015. PMID 22844254 .
- ^ “Waste not, want not—transcript excess in multicellular eukaryotes”. Trends in Genetics 21 (5): 287–288. (May 2005). doi:10.1016/j.tig.2005.02.014. PMID 15851065.
- ^ “Transcriptional noise and the fidelity of initiation by RNA polymerase II”. Nature Structural & Molecular Biology 14 (2): 103–105. (February 2007). doi:10.1038/nsmb0207-103. PMID 17277804.
- ^ “Non-coding RNA: what is functional and what is junk?”. Frontiers in Genetics 6: 2. (2015-01-26). doi:10.3389/fgene.2015.00002. PMC 4306305. PMID 25674102 .
- ^ “Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications”. Trends in Genetics 30 (10): 439–452. (October 2014). doi:10.1016/j.tig.2014.08.004. PMC 4464757. PMID 25218058 .
- ^ “Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs”. Genome Biology 17: 19. (February 2016). doi:10.1186/s13059-016-0880-9. PMC 4739325. PMID 26838501 .
- ^ “Evolution to the rescue: using comparative genomics to understand long non-coding RNAs”. Nature Reviews Genetics 17 (10): 601–614. (October 2016). doi:10.1038/nrg.2016.85. PMID 27573374.
- ^ “Principles of long noncoding RNA evolution derived from direct comparison of transcriptomes in 17 species”. Cell Reports 11 (7): 1110–1122. (May 2015). doi:10.1016/j.celrep.2015.04.023. PMC 4576741. PMID 25959816 .
- ^ “Evolutionary conservation of long non-coding RNAs; sequence, structure, function”. Biochimica et Biophysica Acta (BBA) - General Subjects 1840 (3): 1063–1071. (March 2014). doi:10.1016/j.bbagen.2013.10.035. PMC 3909678. PMID 24184936 .
- ^ “A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs”. Nature Methods 14 (1): 45–48. (January 2017). doi:10.1038/nmeth.4066. PMC 5554622. PMID 27819659 .
- ^ “Long non-coding RNAs: insights into functions”. Nature Reviews Genetics 10 (3): 155–159. (March 2009). doi:10.1038/nrg2521. PMID 19188922.
- ^ “Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications”. Briefings in Functional Genomics & Proteomics 8 (6): 407–423. (November 2009). doi:10.1093/bfgp/elp038. PMID 19770204.
- ^ “lncRNAdb: a reference database for long noncoding RNAs”. Nucleic Acids Research 39 (Database issue): D146–51. (January 2011). doi:10.1093/nar/gkq1138. PMC 3013714. PMID 21112873 .
- ^ “lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs”. Nucleic Acids Research 43 (Database issue): D168–73. (January 2015). doi:10.1093/nar/gku988. PMC 4384040. PMID 25332394 .
- ^ Ma, Lina; Li, Ang; Zou, Dong; Xu, Xingjian; Xia, Lin; Yu, Jun; Bajic, Vladimir B.; Zhang, Zhang (2015-01). “LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs”. Nucleic Acids Research 43 (Database issue): D187–192. doi:10.1093/nar/gku1167. ISSN 1362-4962. PMC 4383965. PMID 25399417 .
- ^ “Translation of small open reading frames within unannotated RNA transcripts in Saccharomyces cerevisiae”. Cell Reports 7 (6): 1858–1866. (June 2014). doi:10.1016/j.celrep.2014.05.023. PMC 4105149. PMID 24931603 .
- ^ a b “Non-coding-RNA regulators of RNA polymerase II transcription”. Nature Reviews Molecular Cell Biology 7 (8): 612–616. (August 2006). doi:10.1038/nrm1946. PMID 16723972.
- ^ a b “The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator”. Genes & Development 20 (11): 1470–1484. (June 2006). doi:10.1101/gad.1416106. PMC 1475760. PMID 16705037 .
- ^ “Developmental functions of the Distal-less/Dlx homeobox genes”. Development 129 (19): 4371–4386. (October 2002). doi:10.1242/dev.129.19.4371. PMID 12223397 .
- ^ “In vivo enhancer analysis of human conserved non-coding sequences”. Nature 444 (7118): 499–502. (November 2006). Bibcode: 2006Natur.444..499P. doi:10.1038/nature05295. PMID 17086198 .
- ^ “Ultraconservation identifies a small subset of extremely constrained developmental enhancers”. Nature Genetics 40 (2): 158–160. (February 2008). doi:10.1038/ng.2007.55. PMC 2647775. PMID 18176564 .
- ^ “Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas”. Cancer Genetics and Cytogenetics 133 (1): 55–60. (February 2002). doi:10.1016/S0165-4608(01)00634-3. PMID 11890990.
- ^ a b c “Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas”. Cancer Cell 12 (3): 215–229. (September 2007). doi:10.1016/j.ccr.2007.07.027. PMID 17785203.
- ^ “Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells”. Cell Stem Cell 18 (5): 637–652. (May 2016). doi:10.1016/j.stem.2016.01.024. PMID 26996597.
- ^ “Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription”. Nature 454 (7200): 126–130. (July 2008). Bibcode: 2008Natur.454..126W. doi:10.1038/nature06992. PMC 2823488. PMID 18509338 .
- ^ “Non-coding RNA: More uses for genomic junk”. Nature 543 (7644): 183–185. (March 2017). Bibcode: 2017Natur.543..183A. doi:10.1038/543183a. PMID 28277509.
- ^ “Regulation of the apolipoprotein gene cluster by a long noncoding RNA”. Cell Reports 6 (1): 222–230. (January 2014). doi:10.1016/j.celrep.2013.12.015. PMC 3924898. PMID 24388749 .
- ^ “Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse”. BMC Genomics 11: 614. (November 2010). doi:10.1186/1471-2164-11-614. PMC 3091755. PMID 21047393 .
- ^ “Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript”. Nature 445 (7128): 666–670. (February 2007). doi:10.1038/nature05519. PMID 17237763.
- ^ “A monoclonal antibody to triplex DNA binds to eucaryotic chromosomes”. Nucleic Acids Research 15 (3): 1047–1061. (February 1987). doi:10.1093/nar/15.3.1047. PMC 340507. PMID 2434928 .
- ^ a b “U1 snRNA associates with TFIIH and regulates transcriptional initiation”. Nature Structural Biology 9 (11): 800–805. (November 2002). doi:10.1038/nsb862. PMID 12389039.
- ^ “Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells”. Molecular and Cellular Biology 21 (22): 7807–7816. (November 2001). doi:10.1128/MCB.21.22.7807-7816.2001. PMC 99950. PMID 11604515 .
- ^ “Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA”. Molecular Cell 12 (4): 971–982. (October 2003). doi:10.1016/S1097-2765(03)00388-5. PMID 14580347.
- ^ Lander, E. S.; Linton, L. M.; Birren, B.; Nusbaum, C.; Zody, M. C.; Baldwin, J.; Devon, K.; Dewar, K. et al. (2001-02-15). “Initial sequencing and analysis of the human genome”. Nature 409 (6822): 860–921. doi:10.1038/35057062. ISSN 0028-0836. PMID 11237011 .
- ^ Mouse Genome Sequencing Consortium; Waterston, Robert H.; Lindblad-Toh, Kerstin; Birney, Ewan; Rogers, Jane; Abril, Josep F.; Agarwal, Pankaj; Agarwala, Richa et al. (2002-12-05). “Initial sequencing and comparative analysis of the mouse genome”. Nature 420 (6915): 520–562. doi:10.1038/nature01262. ISSN 0028-0836. PMID 12466850 .
- ^ “Cell stress and translational inhibitors transiently increase the abundance of mammalian SINE transcripts”. Nucleic Acids Research 23 (10): 1758–1765. (May 1995). doi:10.1093/nar/23.10.1758. PMC 306933. PMID 7784180 .
- ^ a b “Evolution of microRNA genes by inverted duplication of target gene sequences in Arabidopsis thaliana”. Nature Genetics 36 (12): 1282–1290. (December 2004). doi:10.1038/ng1478. PMID 15565108.
- ^ a b “B2 RNA binds directly to RNA polymerase II to repress transcript synthesis”. Nature Structural & Molecular Biology 11 (9): 822–829. (September 2004). doi:10.1038/nsmb812. PMID 15300239.
- ^ “Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription”. RNA 13 (4): 583–596. (April 2007). doi:10.1261/rna.310307. PMC 1831867. PMID 17307818 .
- ^ a b c d e f “Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock”. Molecular Cell 29 (4): 499–509. (February 2008). doi:10.1016/j.molcel.2007.12.013. PMID 18313387.
- ^ “Modular RNA heats up”. Molecular Cell 29 (4): 415–417. (February 2008). doi:10.1016/j.molcel.2008.02.001. PMID 18313380.
- ^ “Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms”. BioEssays 25 (10): 930–939. (October 2003). doi:10.1002/bies.10332. PMID 14505360.
- ^ “Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region”. Molecular and Cellular Biology 28 (11): 3713–3728. (June 2008). doi:10.1128/MCB.02263-07. PMC 2423283. PMID 18299392 .
- ^ “Chromosomal silencing and localization are mediated by different domains of Xist RNA”. Nature Genetics 30 (2): 167–174. (February 2002). doi:10.1038/ng820. PMID 11780141.
- ^ “Identification of new Xlsirt family members in the Xenopus laevis oocyte”. Mechanisms of Development 120 (4): 503–509. (April 2003). doi:10.1016/S0925-4773(02)00459-8. PMID 12676327.
- ^ “Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells”. Nature 314 (6011): 553–556. (1985). Bibcode: 1985Natur.314..553S. doi:10.1038/314553a0. PMID 2581137.
- ^ “Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue”. Molecular Carcinogenesis 42 (2): 93–96. (February 2005). doi:10.1002/mc.20057. PMID 15593371.
- ^ a b “Gene control by large noncoding RNAs”. Science's STKE 2006 (355): pe40. (October 2006). doi:10.1126/stke.3552006pe40. PMID 17018852.
- ^ a b “The expanding RNA polymerase III transcriptome”. Trends in Genetics 23 (12): 614–622. (December 2007). doi:10.1016/j.tig.2007.09.001. hdl:11381/1706964. PMID 17977614.
- ^ Mallardo, Massimo; Poltronieri, Palmiro; D'Urso, Oscar Fernando (2008-07-16). “Non-protein coding RNA biomarkers and differential expression in cancers: a review”. Journal of experimental & clinical cancer research: CR 27: 19. doi:10.1186/1756-9966-27-19. ISSN 1756-9966. PMC 2490676. PMID 18631387 .
- ^ “Posttranscriptional gene regulation by long noncoding RNA”. The Journal of Molecular Biology 425 (19): 3723–3730. (October 2013). doi:10.1016/j.jmb.2012.11.024. PMC 3594629. PMID 23178169 .
- ^ a b c “A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition”. Genes & Development 22 (6): 756–769. (March 2008). doi:10.1101/gad.455708. PMC 2275429. PMID 18347095 .
- ^ “Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA”. The Journal of Biological Chemistry 266 (33): 22083–22086. (November 1991). doi:10.1016/S0021-9258(18)54535-X. PMID 1657988 .
- ^ “Primary structure, neural-specific expression, and dendritic location of human BC200 RNA”. The Journal of Neuroscience 13 (6): 2382–2390. (June 1993). doi:10.1523/JNEUROSCI.13-06-02382.1993. PMC 6576500. PMID 7684772 .
- ^ “Dendritic location of neural BC1 RNA”. Proceedings of the National Academy of Sciences of the United States of America 88 (6): 2093–2097. (March 1991). Bibcode: 1991PNAS...88.2093T. doi:10.1073/pnas.88.6.2093. PMC 51175. PMID 1706516 .
- ^ “Activity-dependent regulation of dendritic BC1 RNA in hippocampal neurons in culture”. The Journal of Cell Biology 141 (7): 1601–1611. (June 1998). doi:10.1083/jcb.141.7.1601. PMC 1828539. PMID 9647652 .
- ^ “Dendritic BC1 RNA in translational control mechanisms”. The Journal of Cell Biology 171 (5): 811–821. (December 2005). doi:10.1083/jcb.200506006. PMC 1828541. PMID 16330711 .
- ^ “The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum”. The Journal of Neuroscience 27 (33): 8885–8892. (August 2007). doi:10.1523/JNEUROSCI.0548-07.2007. PMC 6672174. PMID 17699670 .
- ^ “Role of a neuronal small non-messenger RNA: behavioural alterations in BC1 RNA-deleted mice”. Behavioural Brain Research 154 (1): 273–289. (September 2004). doi:10.1016/j.bbr.2004.02.015. PMID 15302134.
- ^ “An inside job for siRNAs”. Molecular Cell 31 (3): 309–312. (August 2008). doi:10.1016/j.molcel.2008.07.008. PMC 2675693. PMID 18691963 .
- ^ “An endogenous small interfering RNA pathway in Drosophila”. Nature 453 (7196): 798–802. (June 2008). Bibcode: 2008Natur.453..798C. doi:10.1038/nature07007. PMC 2895258. PMID 18463631 .
- ^ a b “Intersection of the RNA interference and X-inactivation pathways”. Science 320 (5881): 1336–1341. (June 2008). Bibcode: 2008Sci...320.1336O. doi:10.1126/science.1157676. PMC 2584363. PMID 18535243 .
- ^ “Epigenetics in development”. Developmental Dynamics 236 (4): 1144–1156. (April 2007). doi:10.1002/dvdy.21094. PMID 17304537.
- ^ a b “Genome-wide maps of chromatin state in pluripotent and lineage-committed cells”. Nature 448 (7153): 553–560. (August 2007). Bibcode: 2007Natur.448..553M. doi:10.1038/nature06008. PMC 2921165. PMID 17603471 .
- ^ “Chromatin architecture and nuclear RNA”. Proceedings of the National Academy of Sciences of the United States of America 86 (1): 177–181. (January 1989). Bibcode: 1989PNAS...86..177N. doi:10.1073/pnas.86.1.177. PMC 286427. PMID 2911567 .
- ^ “RNA is an integral component of chromatin that contributes to its structural organization”. PLOS ONE 2 (11): e1182. (November 2007). Bibcode: 2007PLoSO...2.1182R. doi:10.1371/journal.pone.0001182. PMC 2063516. PMID 18000552 .
- ^ “Integration of external signaling pathways with the core transcriptional network in embryonic stem cells”. Cell 133 (6): 1106–1117. (June 2008). doi:10.1016/j.cell.2008.04.043. PMID 18555785.
- ^ a b c “Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs”. Cell 129 (7): 1311–1323. (June 2007). doi:10.1016/j.cell.2007.05.022. PMC 2084369. PMID 17604720 .
- ^ a b “Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax”. Science 311 (5764): 1118–1123. (February 2006). Bibcode: 2006Sci...311.1118S. doi:10.1126/science.1117705. PMID 16497925.
- ^ “Oplr16 serves as a novel chromatin factor to control stem cell fate by modulating pluripotency-specific chromosomal looping and TET2-mediated DNA demethylation”. Nucleic Acids Research 48 (7): 3935–3948. (2020). doi:10.1093/nar/gkaa097. PMC 7144914. PMID 32055844 .
- ^ “Transcriptional interference: an unexpected layer of complexity in gene regulation”. Journal of Cell Science 120 (Pt 16): 2755–2761. (August 2007). doi:10.1242/jcs.007633. PMID 17690303.
- ^ “Point mutations in the WD40 domain of Eed block its interaction with Ezh2”. Molecular and Cellular Biology 18 (10): 5634–5642. (October 1998). doi:10.1128/MCB.18.10.5634. PMC 109149. PMID 9742080 .
- ^ “Antisense transcription in the mammalian transcriptome”. Science 309 (5740): 1564–1566. (September 2005). Bibcode: 2005Sci...309.1564R. doi:10.1126/science.1112009. PMID 16141073.
- ^ a b c “Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA”. Nature 451 (7175): 202–206. (January 2008). Bibcode: 2008Natur.451..202Y. doi:10.1038/nature06468. PMC 2743558. PMID 18185590 .
- ^ “Silencing by imprinted noncoding RNAs: is transcription the answer?”. Trends in Genetics 23 (6): 284–292. (June 2007). doi:10.1016/j.tig.2007.03.018. PMC 2847181. PMID 17445943 .
- ^ “The Air noncoding RNA: an imprinted cis-silencing transcript”. Cold Spring Harbor Symposia on Quantitative Biology 69: 55–66. (2004). doi:10.1101/sqb.2004.69.55. PMC 2847179. PMID 16117633 .
- ^ “LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids”. Human Molecular Genetics 8 (7): 1209–1217. (July 1999). doi:10.1093/hmg/8.7.1209. PMID 10369866.
- ^ “Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes”. Genes & Development 20 (10): 1268–1282. (May 2006). doi:10.1101/gad.1416906. PMC 1472902. PMID 16702402 .
- ^ a b “Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes”. Nature Genetics 36 (12): 1296–1300. (December 2004). doi:10.1038/ng1467. PMID 15516932.
- ^ “The non-coding Air RNA is required for silencing autosomal imprinted genes”. Nature 415 (6873): 810–813. (February 2002). Bibcode: 2002Natur.415..810S. doi:10.1038/415810a. PMID 11845212.
- ^ “Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes”. Genes & Development 15 (18): 2361–2366. (September 2001). doi:10.1101/gad.206201. PMC 312779. PMID 11562346 .
- ^ “Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes”. The EMBO Journal 21 (23): 6560–6570. (December 2002). doi:10.1093/emboj/cdf655. PMC 136958. PMID 12456662 .
- ^ a b “X inactivation Xplained”. Current Opinion in Genetics & Development 17 (5): 387–393. (October 2007). doi:10.1016/j.gde.2007.08.001. PMID 17869504.
- ^ “The region 3′ to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene”. The EMBO Journal 23 (3): 594–604. (February 2004). doi:10.1038/sj.emboj.7600071. PMC 1271805. PMID 14749728 .
- ^ “Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals”. Nature 393 (6685): 599–601. (June 1998). Bibcode: 1998Natur.393..599C. doi:10.1038/31275. PMID 9634239.
- ^ “Telomere length, stem cells and aging”. Nature Chemical Biology 3 (10): 640–649. (October 2007). doi:10.1038/nchembio.2007.38. PMID 17876321.
- ^ a b “Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II”. Nature Cell Biology 10 (2): 228–236. (February 2008). doi:10.1038/ncb1685. PMID 18157120.
- ^ a b “Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends”. Science 318 (5851): 798–801. (November 2007). Bibcode: 2007Sci...318..798A. doi:10.1126/science.1147182. PMID 17916692.
- ^ “Asynchronous replication, mono-allelic expression, and long range Cis-effects of ASAR6”. PLOS Genetics 9 (4): e1003423. (April 2013). doi:10.1371/journal.pgen.1003423. PMC 3617217. PMID 23593023 .
- ^ “ASAR15, A cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15”. PLOS Genetics 11 (1): e1004923. (January 2015). doi:10.1371/journal.pgen.1004923. PMC 4287527. PMID 25569254 .
- ^ “Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6”. RNA 26 (6): 724–738. (June 2020). doi:10.1261/rna.073114.119. PMC 7266157. PMID 32144193 .
- ^ “The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements”. Biomolecules 11 (4): 550. (April 2021). doi:10.3390/biom11040550. PMC 8069526. PMID 33918762 .
- ^ “BC200 RNA in normal human neocortex, non-Alzheimer dementia (NAD), and senile dementia of the Alzheimer type (AD)”. Neurochemical Research 17 (6): 591–597. (June 1992). doi:10.1007/bf00968788. PMID 1603265.
- ^ “Primate brain-specific cytoplasmic transcript of the Alu repeat family”. Molecular and Cellular Biology 7 (9): 3324–3327. (September 1987). doi:10.1128/MCB.7.9.3324. PMC 367971. PMID 2444875 .
- ^ a b “Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1”. DNA and Cell Biology 25 (3): 135–141. (March 2006). doi:10.1089/dna.2006.25.135. PMID 16569192.
- ^ “A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas”. Oncogene 26 (6): 851–858. (February 2007). doi:10.1038/sj.onc.1209846. PMID 16878148.
- ^ “Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer”. Oncogene 23 (39): 6684–6692. (August 2004). doi:10.1038/sj.onc.1207880. PMID 15221013.
- ^ “Accumulation of miR-155 and BIC RNA in human B cell lymphomas”. Proceedings of the National Academy of Sciences of the United States of America 102 (10): 3627–3632. (March 2005). Bibcode: 2005PNAS..102.3627E. doi:10.1073/pnas.0500613102. PMC 552785. PMID 15738415 .
- ^ “Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues”. The American Journal of Pathology 150 (4): 1297–1305. (April 1997). PMC 1858164. PMID 9094986 .
- ^ “Long noncoding RNAs in patients with acute myocardial infarction”. Circulation Research 115 (7): 668–677. (September 2014). doi:10.1161/CIRCRESAHA.115.303836. PMID 25035150.
- ^ “Identification and regulation of the long non-coding RNA Heat2 in heart failure”. Journal of Molecular and Cellular Cardiology 126: 13–22. (January 2019). doi:10.1016/j.yjmcc.2018.11.004. PMID 30445017.
- ^ “Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS”. The Journal of Biological Chemistry 280 (25): 24159–24167. (June 2005). doi:10.1074/jbc.M501704200. PMID 15855153 .
- ^ “Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction”. Journal of Human Genetics 51 (12): 1087–1099. (2006). doi:10.1007/s10038-006-0070-9. PMID 17066261.
- ^ “A common allele on chromosome 9 associated with coronary heart disease”. Science 316 (5830): 1488–1491. (June 2007). Bibcode: 2007Sci...316.1488M. doi:10.1126/science.1142447. PMC 2711874. PMID 17478681 .
- ^ “Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF”. Cancer Research 67 (8): 3963–3969. (April 2007). doi:10.1158/0008-5472.CAN-06-2004. PMID 17440112.
- ^ “Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p”. Human Molecular Genetics 17 (6): 806–814. (March 2008). doi:10.1093/hmg/ddm352. PMID 18048406.
- ^ a b “Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus”. Arteriosclerosis, Thrombosis, and Vascular Biology 29 (10): 1671–1677. (October 2009). doi:10.1161/ATVBAHA.109.189522. PMID 19592466.
- ^ “INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis”. PLOS ONE 4 (4): e5027. (April 2009). Bibcode: 2009PLoSO...4.5027L. doi:10.1371/journal.pone.0005027. PMC 2660422. PMID 19343170 .
- ^ “SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease”. Human Molecular Genetics 13 (19): 2221–2231. (October 2004). doi:10.1093/hmg/ddh245. PMID 15294872.
- ^ “Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase”. Nature Medicine 14 (7): 723–730. (July 2008). doi:10.1038/nm1784. PMC 2826895. PMID 18587408 .
- ^ “Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease”. Nature Genetics 34 (2): 157–165. (June 2003). doi:10.1038/ng1157. PMID 12730694.
- ^ “Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination”. Proceedings of the National Academy of Sciences of the United States of America 116 (34): 17121–17126. (August 2019). doi:10.1073/pnas.1822046116. PMID 31399544.
- 1 長鎖ノンコーディングRNAとは
- 2 長鎖ノンコーディングRNAの概要
- 3 長鎖ノンコーディングRNAの同定ツール
- 4 翻訳
- 5 老化と疾患
- 6 関連項目
- lncRNAのページへのリンク