重鎖抗体
(IgNAR から転送)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/03/22 02:32 UTC 版)
重鎖抗体(じゅうさこうたい、英: heavy-chain antibody)は、2本の重鎖のみで構成され、通常の抗体に含まれる2本の軽鎖を持たない抗体である。
- ^ a b Harmsen, M. M.; Haard, H. J. (2007). “Properties, production, and applications of camelid single-domain antibody fragments”. Applied Microbiology and Biotechnology 77 (1): 13–22. doi:10.1007/s00253-007-1142-2. PMC 2039825. PMID 17704915 .
- ^ a b Hamers-Casterman, C; Atarhouch, T; Muyldermans, S; Robinson, G; Hamers, C; Songa, EB; Bendahman, N; Hamers, R (3 June 1993). “Naturally occurring antibodies devoid of light chains”. Nature 363 (6428): 446–8. Bibcode: 1993Natur.363..446H. doi:10.1038/363446a0. PMID 8502296.
- ^ Greenberg, A.S.; Avila, D.; Hughes, M.; Hughes, A.; McKinney, E.C.; Flajnik, M.F. (1995). “A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks”. Nature 374 (6518): 168–173. Bibcode: 1995Natur.374..168G. doi:10.1038/374168a0. PMID 7877689.
- ^ a b Stanfield, R.; Dooley, H.; Flajnik, M.; Wilson, I. (2004). “Crystal structure of a shark single-domain antibody V region in complex with lysozyme”. Science 305 (5691): 1770–1773. Bibcode: 2004Sci...305.1770S. doi:10.1126/science.1101148. PMID 15319492.
- ^ Flajnik, M. F.; Dooley, H. (2009). The Generation and Selection of Single-Domain, V Region Libraries from Nurse Sharks. Methods in Molecular Biology. 562. pp. 71–82. doi:10.1007/978-1-60327-302-2_6. ISBN 978-1-60327-301-5. PMID 19554288
- ^ Conrath, K. E.; Wernery, U.; Muyldermans, S.; Nguyen, V. K. (2003). “Emergence and evolution of functional heavy-chain antibodies in Camelidae”. Developmental and Comparative Immunology 27 (2): 87–103. doi:10.1016/S0145-305X(02)00071-X. PMID 12543123.
- ^ Ghannam, A., Kumari, S., Muyldermans, S., & Abbady, A. Q. (2015). Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses. Plant Molecular Biology, 1-15.
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