Amyloid Precursor Proteinとは？ わかりやすく解説

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エー‐ピー‐ピー【APP】

読み方：えーぴーぴー

《amyloid precursor protein》⇒アミロイド前駆体蛋白質


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アミロイド前駆体タンパク質

(Amyloid Precursor Protein から転送)

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/10/31 04:28 UTC 版)

アミロイド前駆体タンパク質（アミロイドぜんくたいタンパクしつ、英: amyloid precursor protein、略称: APP）またはアミロイドβ前駆体タンパク質は、多くの組織で発現している内在性膜タンパク質で、神経細胞のシナプスに濃縮されている。主要な機能は未知であるが、シナプス形成[5]、神経可塑性（英語版）[6]、抗菌活性[7]、鉄排出[8]の調節因子であると示唆されている。APPは、タンパク質分解によって形成されるアミロイドβ（Aβ）の前駆体として最もよく知られている。Aβは37–49アミノ酸残基からなるポリペプチドで、アミロイド型のAβはアルツハイマー病患者の脳に存在するアミロイド斑の主要な構成要素である。


出典
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142192 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022892 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ a b “Synapse formation and function is modulated by the amyloid precursor protein”. The Journal of Neuroscience 26 (27): 7212–21. (Jul 2006). doi:10.1523/JNEUROSCI.1450-06.2006. PMID 16822978. 
  6. ^ “Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory”. Progress in Neurobiology 70 (1): 1–32. (May 2003). doi:10.1016/S0301-0082(03)00089-3. PMID 12927332. 
  7. ^ “The antimicrobial protection hypothesis of Alzheimer's disease”. Alzheimer's & Dementia 14 (12): 1602-1614. (2018). doi:10.1016/j.jalz.2018.06.3040. PMID 30314800. 
  8. ^ a b “Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease”. Cell 142 (6): 857–67. (Sep 2010). doi:10.1016/j.cell.2010.08.014. PMC 2943017. PMID 20817278. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943017/. 
  9. ^ “Origins of amyloid-β”. BMC Genomics 14 (1): 290. (April 2013). doi:10.1186/1471-2164-14-290. PMC 3660159. PMID 23627794. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660159/. 
  10. ^ “Genomic organization of the human amyloid beta-protein precursor gene”. Gene 87 (2): 257–63. (Mar 1990). doi:10.1016/0378-1119(90)90310-N. PMID 2110105. 
  11. ^ “Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]”. Nature Genetics 5 (1): 22–30. (Sep 1993). doi:10.1038/ng0993-22. PMID 8220418. 
  12. ^ “Expression of APP pathway mRNAs and proteins in Alzheimer's disease”. Brain Research 1161: 116–23. (Aug 2007). doi:10.1016/j.brainres.2007.05.050. PMID 17586478. 
  13. ^ Ewald, Collin Y.; Li, Chris (2012-04-01). “Caenorhabditis elegans as a model organism to study APP function” (英語). Experimental Brain Research 217 (3–4): 397–411. doi:10.1007/s00221-011-2905-7. ISSN 0014-4819. PMC 3746071. PMID 22038715. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746071/. 
  14. ^ a b c d “The amyloid precursor protein: beyond amyloid”. Molecular Neurodegeneration 1 (1): 5. (2006). doi:10.1186/1750-1326-1-5. PMC 1538601. PMID 16930452. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538601/. 
  15. ^ “Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease”. Nature 349 (6311): 704–6. (Feb 1991). doi:10.1038/349704a0. PMID 1671712. 
  16. ^ “A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease”. Science 254 (5028): 97–9. (Oct 1991). doi:10.1126/science.1925564. PMID 1925564. 
  17. ^ “Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene”. Nature 353 (6347): 844–6. (Oct 1991). doi:10.1038/353844a0. PMID 1944558. 
  18. ^ “Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production”. Nature 360 (6405): 672–4. (Dec 1992). doi:10.1038/360672a0. PMID 1465129. 
  19. ^ “A mutation in APP protects against Alzheimer's disease and age-related cognitive decline”. Nature 488 (7409): 96–9. (Aug 2012). doi:10.1038/nature11283. PMID 22801501. 
  20. ^ a b PDB 1RW6; “The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain”. Molecular Cell 15 (3): 343–53. (Aug 2004). doi:10.1016/j.molcel.2004.06.037. PMID 15304215. 
  21. ^ “Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein”. Proceedings of the National Academy of Sciences of the United States of America 107 (12): 5381–6. (Mar 2010). doi:10.1073/pnas.0911326107. PMC 2851805. PMID 20212142. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851805/. ; see also PDB ID 3KTM
  22. ^ “Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system”. The Journal of Neuroscience 13 (7): 3136–42. (Jul 1993). PMID 8331390. 
  23. ^ “Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein”. Nature Structural Biology 6 (4): 327–31. (Apr 1999). doi:10.1038/7562. PMID 10201399. ; see also PDB ID 1MWP
  24. ^ a b “Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions”. Journal of Molecular Biology 367 (1): 148–61. (Mar 2007). doi:10.1016/j.jmb.2006.12.041. PMID 17239395. ; See also 2007 PDB IDs 2FJZ, 2FK2, 2FKL.
  25. ^ “Proteolytic processing and cell biological functions of the amyloid precursor protein”. Journal of Cell Science 113 (11): 1857–70. (Jun 2000). PMID 10806097. 
  26. ^ “TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity”. Nature 440 (7088): 1208–12. (Apr 2006). doi:10.1038/nature04667. PMID 16641999. 
  27. ^ “Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts”. The Journal of Cell Biology 160 (1): 113–23. (Jan 2003). doi:10.1083/jcb.200207113. PMC 2172747. PMID 12515826. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172747/. 
  28. ^ “Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes”. The Journal of Biological Chemistry 279 (43): 44945–54. (Oct 2004). doi:10.1074/jbc.M407986200. PMC 1201506. PMID 15322084. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201506/. 
  29. ^ “Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts”. Current Biology 11 (16): 1288–93. (Aug 2001). doi:10.1016/S0960-9822(01)00394-3. PMID 11525745. 
  30. ^ “Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration”. Annual Review of Neuroscience 26 (1): 565–97. (2003). doi:10.1146/annurev.neuro.26.041002.131334. PMID 12730322. 
  31. ^ “No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice”. Neuroscience 90 (4): 1207–16. (1999). doi:10.1016/S0306-4522(98)00645-9. PMID 10338291. 
  32. ^ “Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice”. NeuroReport 18 (10): 1083–7. (2007). doi:10.1097/WNR.0b013e3281e72b18. PMID 17558301. 
  33. ^ “Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies”. Journal of Neuropathology and Experimental Neurology 67 (8): 773–83. (Aug 2008). doi:10.1097/NEN.0b013e318180ec47. PMC 3334532. PMID 18648325. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334532/. 
  34. ^ a b “Somatic APP gene recombination in Alzheimer's disease and normal neurons”. Nature 563 (7733): 639–645. (November 2018). doi:10.1038/s41586-018-0718-6. PMC 6391999. PMID 30464338. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391999/. 
  35. ^ “A peptide zipcode sufficient for anterograde transport within amyloid precursor protein”. Proceedings of the National Academy of Sciences of the United States of America 103 (44): 16532–7. (Oct 2006). doi:10.1073/pnas.0607527103. PMC 1621108. PMID 17062754. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621108/. 
  36. ^ “Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon”. Physical Biology 9 (5): 055005. (Oct 2012). doi:10.1088/1478-3975/9/5/055005. PMC 3625656. PMID 23011729. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625656/. 
  37. ^ “Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease”. Biochemical Society Transactions 36 (Pt 6): 1282–7. (Dec 2008). doi:10.1042/BST0361282. PMC 2746665. PMID 19021541. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746665/. 
  38. ^ “A synthetic peptide with the putative iron binding motif of amyloid precursor protein (APP) does not catalytically oxidize iron”. PLOS ONE 7 (8): e40287. (2012). doi:10.1371/journal.pone.0040287. PMC 3419245. PMID 22916096. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419245/. 
  39. ^ “The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain”. PLOS ONE 8 (8): e72177. (2013). doi:10.1371/journal.pone.0072177. PMC 3747053. PMID 23977245. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747053/. 
  40. ^ “sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin”. EMBO Reports 15 (7): 809–15. (Jul 2014). doi:10.15252/embr.201338064. PMC 4196985. PMID 24867889. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196985/. 
  41. ^ “Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropin”. Biochemical and Biophysical Research Communications 364 (3): 522–7. (Dec 2007). doi:10.1016/j.bbrc.2007.10.021. PMID 17959150. 
  42. ^ “Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells”. The Journal of Biological Chemistry 284 (35): 23806–17. (Aug 2009). doi:10.1074/jbc.M109.026328. PMC 2749153. PMID 19542221. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749153/. 
  43. ^ “Opioid and progesterone signaling is obligatory for early human embryogenesis”. Stem Cells and Development 18 (5): 737–40. (Jun 2009). doi:10.1089/scd.2008.0190. PMC 2891507. PMID 18803462. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891507/. 
  44. ^ “The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes”. Stem Cell Research & Therapy 1 (4): 28. (2010). doi:10.1186/scrt28. PMC 2983441. PMID 20836886. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983441/. 
  45. ^ “DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3”. The Journal of Neuroscience 23 (17): 6914–27. (Jul 2003). PMID 12890786. 
  46. ^ “Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition”. The Journal of Biological Chemistry 279 (19): 20539–45. (May 2004). doi:10.1074/jbc.M311993200. PMID 14871891. 
  47. ^ a b c “Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms”. The Journal of Neuroscience 22 (17): 7340–51. (Sep 2002). doi:10.1523/JNEUROSCI.22-17-07340.2002. PMID 12196555. 
  48. ^ a b “The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein”. Molecular and Cellular Biology 16 (11): 6229–41. (Nov 1996). doi:10.1128/mcb.16.11.6229. PMC 231626. PMID 8887653. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231626/. 
  49. ^ a b “Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism”. The Journal of Biological Chemistry 278 (49): 49448–58. (Dec 2003). doi:10.1074/jbc.M306024200. PMID 12972431. 
  50. ^ “Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein”. The Journal of Biological Chemistry 274 (4): 2243–54. (Jan 1999). doi:10.1074/jbc.274.4.2243. PMID 9890987. 
  51. ^ “X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein”. Biochemical and Biophysical Research Communications 255 (3): 663–7. (Feb 1999). doi:10.1006/bbrc.1999.0265. PMID 10049767. 
  52. ^ “Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins”. The Journal of Biological Chemistry 272 (10): 6399–405. (Mar 1997). doi:10.1074/jbc.272.10.6399. PMID 9045663. 
  53. ^ “Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein”. Proceedings of the National Academy of Sciences of the United States of America 93 (20): 10832–7. (Oct 1996). doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38241/. 
  54. ^ “Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein”. Neuroscience Letters 261 (3): 143–6. (Feb 1999). doi:10.1016/S0304-3940(98)00995-1. PMID 10081969. 
  55. ^ “Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein”. The Journal of Biological Chemistry 273 (50): 33556–60. (Dec 1998). doi:10.1074/jbc.273.50.33556. PMID 9837937. 
  56. ^ “APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein”. The Journal of Biological Chemistry 271 (19): 11339–46. (May 1996). doi:10.1074/jbc.271.19.11339. PMID 8626687. 
  57. ^ “PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein”. Proceedings of the National Academy of Sciences of the United States of America 95 (25): 14745–50. (Dec 1998). doi:10.1073/pnas.95.25.14745. PMC 24520. PMID 9843960. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24520/. 
  58. ^ “Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria”. The Journal of Biological Chemistry 278 (16): 14461–8. (Apr 2003). doi:10.1074/jbc.M209684200. PMID 12529377. 
  59. ^ “Human bleomycin hydrolase regulates the secretion of amyloid precursor protein”. FASEB Journal 14 (12): 1837–47. (Sep 2000). doi:10.1096/fj.99-0938com. PMID 10973933. 
  60. ^ “Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation”. The Journal of Biological Chemistry 279 (23): 24343–54. (Jun 2004). doi:10.1074/jbc.M401925200. PMID 15037614. 
  61. ^ “Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein”. The Journal of Biological Chemistry 273 (17): 10485–95. (Apr 1998). doi:10.1074/jbc.273.17.10485. PMID 9553108. 
  62. ^ “CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV”. The EMBO Journal 21 (7): 1524–34. (Apr 2002). doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125364/. 
  63. ^ “Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function”. Journal of Neurochemistry 76 (5): 1411–20. (Mar 2001). doi:10.1046/j.1471-4159.2001.00144.x. PMID 11238726. 
  64. ^ “Binding of gelsolin, a secretory protein, to amyloid beta-protein”. Biochemical and Biophysical Research Communications 258 (2): 241–6. (May 1999). doi:10.1006/bbrc.1999.0623. PMID 10329371. 
  65. ^ “An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease”. Nature 389 (6652): 689–95. (Oct 1997). doi:10.1038/39522. PMID 9338779. 
  66. ^ “Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc”. The Journal of Biological Chemistry 277 (19): 16798–804. (May 2002). doi:10.1074/jbc.M110286200. PMID 11877420. 
  67. ^ “Interaction of reelin with amyloid precursor protein promotes neurite outgrowth”. The Journal of Neuroscience 29 (23): 7459–73. (Jun 2009). doi:10.1523/JNEUROSCI.4872-08.2009. PMC 2759694. PMID 19515914. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759694/. 

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