β2-ミクログロブリン
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/01/28 03:52 UTC 版)
β2-ミクログロブリンもしくはβ2-マイクログロブリン(英: beta-2 microglobulin)は、MHCクラスI分子の構成要素である。MHCクラスI分子は赤血球を除く全ての有核細胞に存在している[5][6]。ヒトでは、β2-ミクログロブリンはB2M遺伝子にコードされている[6][7][8]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166710、ENSG00000273686 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060802 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Entrez Gene: Beta-2-microglobulin”. 2023年1月22日閲覧。
- ^ a b “The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit”. Journal of Immunology 139 (9): 3132–8. (November 1987). PMID 3312414 .
- ^ “The complete amino acid sequence of beta 2-microglobulin”. Biochemistry 12 (24): 4811–22. (November 1973). doi:10.1021/bi00748a001. PMID 4586824.
- ^ “Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin”. Proceedings of the National Academy of Sciences of the United States of America 78 (11): 6613–7. (November 1981). Bibcode: 1981PNAS...78.6613S. doi:10.1073/pnas.78.11.6613. PMC 349099. PMID 6171820 .
- ^ Singh, Ram Raj; Yang, Jun-Qi; Kim, Peter J.; Halder, Ramesh C. (2013-03-27). “Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus”. Arthritis Research & Therapy 15 (2): R47. doi:10.1186/ar4206. ISSN 1478-6362. PMC 3672782. PMID 23531237 .
- ^ “Chapter 3: Iron, Heme, and Hemoglobin”. Hematology: A Pathophysiologic Approach (1st ed.). (2011). pp. 17–25. ISBN 978-0-323-04311-3
- ^ del Val, M.; Hengel, H.; Häcker, H.; Hartlaub, U.; Ruppert, T.; Lucin, P.; Koszinowski, U. H. (1992-09-01). “Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment”. The Journal of Experimental Medicine 176 (3): 729–738. doi:10.1084/jem.176.3.729. ISSN 0022-1007. PMC 2119349. PMID 1324970 .
- ^ Zijlstra, M.; Bix, M.; Simister, N. E.; Loring, J. M.; Raulet, D. H.; Jaenisch, R. (1990-04-19). “Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells”. Nature 344 (6268): 742–746. doi:10.1038/344742a0. ISSN 0028-0836. PMID 2139497 .
- ^ Morgan, C. J.; Gelfand, M.; Atreya, C.; Miranker, A. D. (2001-06-01). “Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation”. Journal of Molecular Biology 309 (2): 339–345. doi:10.1006/jmbi.2001.4661. ISSN 0022-2836. PMID 11371157 .
- ^ “Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects”. Medical Journal, Armed Forces India 53 (4): 251–254. (October 1997). doi:10.1016/S0377-1237(17)30746-3. PMC 5531080. PMID 28769505 .
- ^ Pignone M, Nicoll D; McPhee SJ (2004). Pocket guide to diagnostic tests (4th ed.). New York: McGraw-Hill. pp. 191. ISBN 0-07-141184-4
- ^ “Chapter 111: Plasma Cell Disorders”. Harrison's Principles of Internal Medicine (18th ed.). McGraw-Hill Professional. (2011). pp. 936–44. ISBN 978-0-07-174889-6
- ^ “MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management”. Hematology. American Society of Hematology. Education Program 2005: 340–5. (2005). doi:10.1182/asheducation-2005.1.340. PMID 16304401.
- ^ “Serum levels of beta 2 microglobulin and interleukin-6 to differentiate monoclonal gammopathy of undetermined significance”. Blood 80 (9): 2433–4. (November 1992). doi:10.1182/blood.V80.9.2433.2433. PMID 1421418.
- 1 β2-ミクログロブリンとは
- 2 β2-ミクログロブリンの概要
- 3 構造と機能
- 4 臨床的意義
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