インターロイキン-21
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/01/01 08:13 UTC 版)
薬剤開発
複数の炎症性疾患に対して抗IL-21抗体が開発されている(Clinicaltrials.gov entries)。
関連文献
- “Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses”. Immunology 112 (2): 177–82. (June 2004). doi:10.1111/j.1365-2567.2004.01886.x. PMC 1782493. PMID 15147560 .
- “Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation”. Nature Reviews. Immunology 5 (9): 688–98. (September 2005). doi:10.1038/nri1688. PMID 16138102.
- “Interleukin-21: a new modulator of immunity, infection, and cancer”. Cytokine & Growth Factor Reviews 18 (3–4): 223–32. (2007). doi:10.1016/j.cytogfr.2007.04.003. PMID 17509926.
- “Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation”. The Journal of Biological Chemistry 271 (17): 10334–40. (April 1996). doi:10.1074/jbc.271.17.10334. PMID 8626603.
- “Cytokines: IL-21 joins the gamma(c)-dependent network?”. Current Biology 11 (5): R175-7. (March 2001). doi:10.1016/S0960-9822(01)00087-2. PMID 11267886.
- “Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex”. Journal of Immunology 167 (1): 1–5. (July 2001). doi:10.4049/jimmunol.167.1.1. PMID 11418623.
- “IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response”. Journal of Immunology 169 (7): 3600–5. (October 2002). doi:10.4049/jimmunol.169.7.3600. PMID 12244150.
- “Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain”. Biochemical and Biophysical Research Communications 300 (2): 291–6. (January 2003). doi:10.1016/S0006-291X(02)02836-X. PMID 12504082.
- “IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells”. Journal of Immunology 170 (11): 5464–9. (June 2003). doi:10.4049/jimmunol.170.11.5464. PMID 12759422.
- “Interleukin-21 inhibits dendritic cell activation and maturation”. Blood 102 (12): 4090–8. (December 2003). doi:10.1182/blood-2003-03-0669. PMID 12893770.
- “IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors”. European Journal of Immunology 33 (12): 3439–47. (December 2003). doi:10.1002/eji.200324533. PMID 14635054.
- “Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells”. Journal of Immunology 172 (9): 5154–7. (May 2004). doi:10.4049/jimmunol.172.9.5154. PMID 15100251.
- “IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells”. Journal of Leukocyte Biology 76 (2): 416–22. (August 2004). doi:10.1189/jlb.1003488. PMID 15178704.
- “[Cloning and expression of human interleukin-21 cDNA in E.coli]”. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology 20 (4): 406–9. (July 2004). PMID 15207081.
- “Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6”. Journal of Immunology 173 (9): 5361–71. (November 2004). doi:10.4049/jimmunol.173.9.5361. PMID 15494482.
- “NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression”. Proceedings of the National Academy of Sciences of the United States of America 102 (6): 2016–21. (February 2005). Bibcode: 2005PNAS..102.2016M. doi:10.1073/pnas.0409512102. PMC 548571. PMID 15684054 .
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138684 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027718 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d “Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function”. Nature 408 (6808): 57–63. (November 2000). Bibcode: 2000Natur.408...57P. doi:10.1038/35040504. PMID 11081504.
- ^ “Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration”. Journal of Immunology 179 (9): 5886–96. (November 2007). doi:10.4049/jimmunol.179.9.5886. PMID 17947662.
- ^ a b “Entrez Gene: IL21 interleukin 21”. 2021年7月23日閲覧。
- ^ Parrish-Novak, Julia; Foster, Donald C.; Holly, Richard D.; Clegg, Christopher H. (2002-11). “Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses”. Journal of Leukocyte Biology 72 (5): 856–863. ISSN 0741-5400. PMID 12429707 .
- ^ “T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells”. Journal of Immunology 173 (1): 68–78. (July 2004). doi:10.4049/jimmunol.173.1.68. PMID 15210760.
- ^ “IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner”. The Journal of Biological Chemistry 282 (48): 34605–10. (November 2007). doi:10.1074/jbc.M705100200. PMC 2323680. PMID 17884812 .
- ^ “Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells”. The Journal of Experimental Medicine 196 (7): 969–77. (October 2002). doi:10.1084/jem.20020620. PMC 2194031. PMID 12370258 .
- ^ “Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions”. Immunity 44 (1): 167–178. (January 2016). doi:10.1016/j.immuni.2015.12.011. PMID 26795249.
- ^ “IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production”. Journal of Immunology 178 (5): 2827–34. (March 2007). doi:10.4049/jimmunol.178.5.2827. PMID 17312126.
- ^ “Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha”. Blood 112 (8): 3339–47. (October 2008). doi:10.1182/blood-2008-01-134783. PMID 18684866.
- ^ “Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain”. Proceedings of the National Academy of Sciences of the United States of America 97 (21): 11439–44. (October 2000). doi:10.1073/pnas.200360997. PMC 17218. PMID 11016959 .
- ^ “Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex”. Journal of Immunology 167 (1): 1–5. (July 2001). doi:10.4049/jimmunol.167.1.1. PMID 11418623.
- ^ a b “The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3”. Biochemistry 41 (27): 8725–31. (July 2002). doi:10.1021/bi0202023. PMID 12093291.
- ^ “A critical role for IL-21 in regulating immunoglobulin production”. Science 298 (5598): 1630–4. (November 2002). Bibcode: 2002Sci...298.1630O. doi:10.1126/science.1077002. PMID 12446913 .
- ^ “IL-21 administration into the nostril alleviates murine allergic rhinitis”. Journal of Immunology 179 (10): 7157–65. (November 2007). doi:10.4049/jimmunol.179.10.7157. PMID 17982108.
- ^ “IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice”. Journal of Immunology 179 (12): 8554–61. (December 2007). doi:10.4049/jimmunol.179.12.8554. PMID 18056403.
- ^ “IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response”. Journal of Immunology 175 (4): 2261–9. (August 2005). doi:10.4049/jimmunol.175.4.2261. PMID 16081794.
- ^ “IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21”. Journal of Immunology 173 (2): 900–9. (July 2004). doi:10.4049/jimmunol.173.2.900. PMID 15240677.
- ^ “IL-21: roles in immunopathology and cancer therapy”. Tissue Antigens 74 (6): 467–79. (December 2009). doi:10.1111/j.1399-0039.2009.01382.x. PMID 19845910.
- ^ “Immunology. A chronic need for IL-21”. Science 324 (5934): 1525–6. (June 2009). doi:10.1126/science.1176487. PMID 19541985.
- ^ “Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)”. Blood 109 (9): 3873–80. (May 2007). doi:10.1182/blood-2006-09-045278. PMC 1874576. PMID 17192392 .
- ^ a b c “HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function”. Journal of Virology 85 (2): 733–41. (January 2011). doi:10.1128/JVI.02030-10. PMC 3020027. PMID 21047960 .
- ^ a b “IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication”. Journal of Leukocyte Biology 87 (5): 857–67. (May 2010). doi:10.1189/jlb.1009701. PMID 20103765.
- ^ “Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers”. Journal of Virology 85 (5): 2316–24. (March 2011). doi:10.1128/JVI.01476-10. PMC 3067790. PMID 21159862 .
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