エフ‐ジー‐エフ【FGF】
読み方：えふじーえふ
《fibroblast growth factor》線維芽細胞増殖因子。このうち、ヒト塩基性線維芽細胞増殖因子は褥瘡(じょくそう)、皮膚潰瘍の治療剤として利用されている。
線維芽細胞増殖因子
(f g = f から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/03 03:20 UTC 版)
線維芽細胞増殖因子（せんいがさいぼうぞうしょくいんし、英: Fibroblast growth factors、FGF[1]）は、血管新生、創傷治癒、胚発生に関係する成長因子の一種。FGFはヘパリン結合性タンパク質で、細胞表面のプロテオグリカンの一種ヘパラン硫酸と相互作用を持つことがFGFのシグナル伝達に不可欠なことが明らかになっている。FGFは広範囲な細胞や組織の増殖や分化の過程において重要な役割を果たしている。
- ^ G. ルバーニ「“陰の血管”を育てて心臓病を治す」『日経サイエンス』第47巻第6号、日経サイエンス社、2017年、72頁。
- ^ Finklestein S.P., Plomaritoglou A. (2001). “Growth factors”. In Miller L.P., Hayes R.L., eds. Co-edited by Newcomb J.K.. Head Trauma: Basic, Preclinical, and Clinical Directions. New York: Wiley. pp. 165–187. ISBN 0-471-36015-5
- ^ Blaber M, DiSalvo J, Thomas KA (February 1996). “X-ray crystal structure of human acidic fibroblast growth factor”. Biochemistry 35 (7): 2086–94. doi:10.1021/bi9521755. PMID 8652550.
- ^ Ornitz DM, Itoh N (2001). “Fibroblast growth factors”. Genome Biol. 2 (3): reviews3005.1–reviews3005.12. doi:10.1186/gb-2001-2-3-reviews3005. PMC 138918. PMID 11276432.
- ^ Itoh N, Ornitz DM (November 2004). “Evolution of the Fgf and Fgfr gene families”. Trends Genet. 20 (11): 563–569.
- ^ Olsen SK, Garbi M. et al. (2003). “Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs”. J. Biol. Chem. 278 (36): 34226–36. doi:10.1074/jbc.M303183200. PMID 12815063.
- ^ Itoh N, Ornitz DM (January 2008). “Functional evolutionary history of the mouse Fgf gene family”. Dev. Dyn. 237 (1): 18–27. doi:10.1002/dvdy.21388. PMID 18058912.
- ^ a b Koga C, Adati N, Nakata K, Mikoshiba K, Furuhata Y, Sato S, Tei H, Sakaki Y, Kurokawa T (August 1999). “Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis”. Biochemical and Biophysical Research Communications 261 (3): 756–65. doi:10.1006/bbrc.1999.1039. PMID 10441498.
- ^ Kirikoshi H, Sagara N, Saitoh T, Tanaka K, Sekihara H, Shiokawa K, Katoh M (August 2000). “Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22”. Biochemical and Biophysical Research Communications 274 (2): 337–43. doi:10.1006/bbrc.2000.3142. PMID 10913340.
- ^ David Sutherland; Christos Samakovlis; Mark A Krasnow (1996). “branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching”. Cell 87 (6): 1091-1101. doi:10.1016/S0092-8674(00)81803-6. PMID 8978613.
- ^ Fukumoto S (March 2008). “Actions and mode of actions of FGF19 subfamily members”. Endocr. J. 55 (1): 23–31. doi:10.1507/endocrj.KR07E-002. PMID 17878606.
- ^ Armelin HA (September 1973). “Pituitary extracts and steroid hormones in the control of 3T3 cell growth”. Proc. Natl. Acad. Sci. U.S.A. 70 (9): 2702–6. Bibcode: 1973PNAS...70.2702A. doi:10.1073/pnas.70.9.2702. PMC 427087. PMID 4354860.
- ^ Gospodarowicz D (1974). “Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth”. Nature 249 (453): 123–7. Bibcode: 1974Natur.249..123G. doi:10.1038/249123a0. PMID 4364816.
- ^ Arese M, Chen Y., et al. (1999). “Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals”. Mol. Biol. Cell 10 (5): 1429–44. PMC 25296. PMID 10233154.
- ^ Vlodavsky I, Korner G, Ishai-Michaeli R, Bashkin P, Bar-Shavit R, Fuks Z (1990). “Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis”. Cancer Metastasis Rev 9 (3): 203–26. doi:10.1007/BF00046361. PMID 1705486.
- ^ Green PJ, Walsh FS, Doherty P (1996). “Promiscuity of fibroblast growth factor receptors”. BioEssays 18 (8): 639–46. doi:10.1002/bies.950180807. PMID 8760337.
- ^ Böttcher RT, Niehrs C. (2005). “Fibroblast growth factor signaling during early vertebrate development”. Endocr. Rev. 26 (1): 63–77. doi:10.1210/er.2003-0040. PMID 15689573.
- ^ Amaya E, Musci T.J. and Kirschner M.W. (1991). “Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos”. Cell 66 (2): 257–270. doi:10.1016/0092-8674(91)90616-7. PMID 1649700.
- ^ Borland C.Z., Schutzman J.L. and Stern M.J. (2001). “Fibroblast growth factor signaling in Caenorhabditis elegans”. BioEssays 23 (12): 1120–1130. doi:10.1002/bies.10007. PMID 11746231.
- ^ Coumoul X. and Deng C.X. (2003). “Roles of FGF receptors in mammalian development and congenital diseases”. Birth Defects Res C Embryo Today 69 (4): 286–304. doi:10.1002/bdrc.10025. PMID 14745970.
- ^ Sutherland D, Samakovlis C . and Krasnow M.A. (1996). “Branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching”. Cell 87 (6): 1091–1101. doi:10.1016/S0092-8674(00)81803-6. PMID 8978613.
- ^ Vlodavsky Cao R, Bråkenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P, Cao Y (2003). “Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2”. Nature Med 9 (5): 604–13. doi:10.1038/nm848. PMID 12669032.
- ^ http://www.ncbi.nlm.nih.gov/pubmed/12845521, Reuss B, von Bohlen und Halbach O. 2003. Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res 313: 139-157.
- ^ http://www.ncbi.nlm.nih.gov/pubmed/20581332, Zechel S, Werner S, Unsicker K, von Bohlen und Halbach O. 2010. Expression and functions of fibroblast growth factor 2 (FGF-2) in hippocampal formation. Neuroscientist 16: 357-373.
- ^ Murzin AG, Lesk AM, Chothia C (January 1992). “beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors”. J. Mol. Biol. 223 (2): 531–43. doi:10.1016/0022-2836(92)90668-A. PMID 1738162.
- ^ Eriksson AE, Cousens LS, Weaver LH, Matthews BW (April 1991). “Three-dimensional structure of human basic fibroblast growth factor”. Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3441–5. Bibcode: 1991PNAS...88.3441E. doi:10.1073/pnas.88.8.3441. PMC 51463. PMID 1707542.
- ^ Gimenez-Gallego G, Rodkey J, Bennett C, Rios-Candelore M, DiSalvo J, Thomas K (December 1985). “Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies”. Science 230 (4732): 1385–8. Bibcode: 1985Sci...230.1385G. doi:10.1126/science.4071057. PMID 4071057.
- ^ 宮尾佳伸「フィブラスト」『ファルマシア』第37巻第8号、2001年、738-739頁、doi:10.14894/faruawpsj.37.8_738。
[続きの解説]
「線維芽細胞増殖因子」の続きの解説一覧
- 1 線維芽細胞増殖因子とは
- 2 線維芽細胞増殖因子の概要
- 3 機能
- 4 構造
- f g = fのページへのリンク
