MAP3K7
(TAK1 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/11/19 09:13 UTC 版)
MAP3K7（mitogen-activated protein kinase kinase kinase 7）またはTAK1（TGF-beta activated kinase 1）は、ヒトではMAP3K7遺伝子にコードされる酵素である[3]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135341 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Kondo, M.; Osada, H.; Uchida, K.; Yanagisawa, K.; Masuda, A.; Takagi, K.; Takahashi, T.; Takahashi, T. (1998-02-09). “Molecular cloning of human TAK1 and its mutational analysis in human lung cancer”. International Journal of Cancer 75 (4): 559–563. doi:10.1002/(sici)1097-0215(19980209)75:4<559::aid-ijc11>3.0.co;2-4. ISSN 0020-7136. PMID 9466656.
- ^ Mihaly, S. R.; Ninomiya-Tsuji, J.; Morioka, S. (2014-11). “TAK1 control of cell death”. Cell Death and Differentiation 21 (11): 1667–1676. doi:10.1038/cdd.2014.123. ISSN 1476-5403. PMC 4211365. PMID 25146924.
- ^ “MAP3K7 mitogen-activated protein kinase kinase kinase 7 [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2022年11月19日閲覧。
- ^ Scarneo, Scott A.; Yang, Kelly W.; Roques, Jose R.; Dai, Alanna; Eibschutz, Liesl S.; Hughes, Philip; Haystead, Timothy A. J. (2020-05-26). “TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades”. Oncotarget 11 (21): 1961–1970. doi:10.18632/oncotarget.27606. ISSN 1949-2553. PMC 7260121. PMID 32523651.
- ^ Scarneo, Scott A.; Eibschutz, Liesl S.; Bendele, Phillip J.; Yang, Kelly W.; Totzke, Juliane; Hughes, Philip; Fox, David A.; Haystead, Timothy A. J. (2019-12-17). “Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice”. Arthritis Research & Therapy 21 (1): 292. doi:10.1186/s13075-019-2073-x. ISSN 1478-6362. PMC 6918687. PMID 31847895.
- ^ Scarneo, Scott A.; Mansourati, Antoine; Eibschutz, Liesl S.; Totzke, Juliane; Roques, Jose R.; Loiselle, David; Carlson, David; Hughes, Philip et al. (2018-11-19). “Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion”. Scientific Reports 8 (1): 17058. doi:10.1038/s41598-018-35189-7. ISSN 2045-2322. PMC 6242965. PMID 30451876.
- ^ a b “ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction”. J. Biol. Chem. 275 (42): 32747–32752. (October 2000). doi:10.1074/jbc.M003042200. PMID 10921914.
- ^ a b c d “The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway”. Nature 398 (6724): 252–256. (March 1999). Bibcode: 1999Natur.398..252N. doi:10.1038/18465. PMID 10094049.
- ^ “Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation”. J. Biol. Chem. 274 (15): 10641–10648. (April 1999). doi:10.1074/jbc.274.15.10641. PMID 10187861.
- ^ a b “Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1”. FEBS Lett. 474 (2–3): 141–145. (June 2000). doi:10.1016/s0014-5793(00)01588-x. PMID 10838074.
- ^ a b c “Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling”. EMBO J. 22 (23): 6277–6288. (December 2003). doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
- ^ “TAK1 is a ubiquitin-dependent kinase of MKK and IKK”. Nature 412 (6844): 346–351. (July 2001). Bibcode: 2001Natur.412..346W. doi:10.1038/35085597. PMID 11460167.
- ^ a b c “TAB3, a new binding partner of the protein kinase TAK1”. Biochem. J. 378 (Pt 1): 27–34. (February 2004). doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
- ^ “Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling”. J. Biol. Chem. 278 (47): 47089–47097. (November 2003). doi:10.1074/jbc.M306002200. PMID 12975377.
- ^ a b “TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway”. Mol. Cell 5 (4): 649–658. (April 2000). doi:10.1016/s1097-2765(00)80244-0. PMID 10882101.
- ^ a b “Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway”. Mol. Cell. Biol. 21 (7): 2475–2484. (April 2001). doi:10.1128/MCB.21.7.2475-2484.2001. PMC 86880. PMID 11259596.
- ^ “BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6”. J. Biol. Chem. 275 (23): 17647–17652. (June 2000). doi:10.1074/jbc.M908622199. PMID 10748100.
- ^ “Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7”. Genes Cells 6 (12): 1091–1099. (December 2001). doi:10.1046/j.1365-2443.2001.00483.x. PMID 11737269.
- ^ “Regulation of the TAK1 signaling pathway by protein phosphatase 2C”. J. Biol. Chem. 276 (8): 5753–5759. (February 2001). doi:10.1074/jbc.M007773200. PMID 11104763.
- ^ Unutmaz, Derya, ed (2008). “TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL”. PLOS ONE 3 (12): e4064. Bibcode: 2008PLoSO...3.4064W. doi:10.1371/journal.pone.0004064. PMC 2603309. PMID 19112497.
- ^ “The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner”. Nat. Cell Biol. 10 (10): 1199–1207. (October 2008). doi:10.1038/ncb1780. PMID 18758450.
[続きの解説]
「MAP3K7」の続きの解説一覧
- 1 MAP3K7とは
- 2 MAP3K7の概要
- 3 シグナル伝達
- 4 関連文献
- 5 外部リンク
- MAP3K7のページへのリンク
