MAP2K1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/11/19 03:50 UTC 版)
MAP2K1（mitogen-activated protein kinase kinase 1）またはMEK1は、ヒトではMAP2K1遺伝子にコードされるタンパク質である[5][6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169032 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004936 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5”. Cytogenet Cell Genet 78 (3–4): 301–3. (Mar 1998). doi:10.1159/000134677. PMID 9465908.
- ^ “Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2”. J Biol Chem 268 (15): 11435–9. (Jun 1993). doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.
- ^ “Entrez Gene: MAP2K1 mitogen-activated protein kinase kinase 1”. 2022年11月19日閲覧。
- ^ “MAP2K1 - My Cancer Genome”. 2022年11月19日閲覧。
- ^ a b “Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis”. PLOS Biol. 8 (10): e1000520. (2010). doi:10.1371/journal.pbio.1000520. PMC 2957403. PMID 20976044.
- ^ a b c Yeung, K; Janosch P; McFerran B; Rose D W; Mischak H; Sedivy J M; Kolch W (May 2000). “Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein”. Mol. Cell. Biol. (UNITED STATES) 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC 85596. PMID 10757792.
- ^ a b Wunderlich, W; Fialka I; Teis D; Alpi A; Pfeifer A; Parton R G; Lottspeich F; Huber L A (Feb 2001). “A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment”. J. Cell Biol. (United States) 152 (4): 765–76. doi:10.1083/jcb.152.4.765. PMC 2195784. PMID 11266467.
- ^ a b Schaeffer, H J; Catling A D; Eblen S T; Collier L S; Krauss A; Weber M J (Sep 1998). “MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade”. Science (UNITED STATES) 281 (5383): 1668–71. Bibcode: 1998Sci...281.1668S. doi:10.1126/science.281.5383.1668. PMID 9733512.
- ^ Nantel, A; Mohammad-Ali K; Sherk J; Posner B I; Thomas D Y (Apr 1998). “Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases”. J. Biol. Chem. (UNITED STATES) 273 (17): 10475–84. doi:10.1074/jbc.273.17.10475. PMID 9553107.
- ^ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997). “Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells”. J. Biol. Chem. (UNITED STATES) 272 (5): 2620–8. doi:10.1074/jbc.272.5.2620. PMID 9006895.
- ^ Butch, E R; Guan K L (Feb 1996). “Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2”. J. Biol. Chem. (UNITED STATES) 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. PMID 8626767.
- ^ Yung, Y; Yao Z; Hanoch T; Seger R (May 2000). “ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK”. J. Biol. Chem. (UNITED STATES) 275 (21): 15799–808. doi:10.1074/jbc.M910060199. PMID 10748187.
- ^ Zheng, C F; Guan K L (Nov 1993). “Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases”. J. Biol. Chem. (UNITED STATES) 268 (32): 23933–9. doi:10.1016/S0021-9258(20)80474-8. PMID 8226933.
- ^ Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (Dec 2000). “A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways”. J. Biol. Chem. (UNITED STATES) 275 (51): 39815–8. doi:10.1074/jbc.C000403200. PMID 11044439.
- ^ Ito, M; Yoshioka K; Akechi M; Yamashita S; Takamatsu N; Sugiyama K; Hibi M; Nakabeppu Y et al. (Nov 1999). “JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway”. Mol. Cell. Biol. (UNITED STATES) 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
- ^ Sanz-Moreno, Victoria; Casar Berta; Crespo Piero (May 2003). “p38α Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels”. Mol. Cell. Biol. (United States) 23 (9): 3079–90. doi:10.1128/MCB.23.9.3079-3090.2003. PMC 153192. PMID 12697810.
- ^ Robinson, Fred L; Whitehurst Angelique W; Raman Malavika; Cobb Melanie H (Apr 2002). “Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1”. J. Biol. Chem. (United States) 277 (17): 14844–52. doi:10.1074/jbc.M107776200. PMID 11823456.
- ^ Xu Be, Be; Stippec S; Robinson F L; Cobb M H (Jul 2001). “Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking”. J. Biol. Chem. (United States) 276 (28): 26509–15. doi:10.1074/jbc.M102769200. PMID 11352917.
- ^ Chen, Z; Cobb M H (May 2001). “Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2”. J. Biol. Chem. (United States) 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.
- ^ Karandikar, M; Xu S; Cobb M H (Dec 2000). “MEKK1 binds raf-1 and the ERK2 cascade components”. J. Biol. Chem. (UNITED STATES) 275 (51): 40120–7. doi:10.1074/jbc.M005926200. PMID 10969079.
[続きの解説]
「MAP2K1」の続きの解説一覧
- 1 MAP2K1とは
- 2 MAP2K1の概要
- 3 機能
- 4 関連文献
- 5 外部リンク
- MAP2K1のページへのリンク
