LKB1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/25 14:27 UTC 版)
LKB1（liver kinase B1）またはSTK11（serine/threonine kinase 11）、renal carcinoma antigen NY-REN-19は、ヒトではSTK11遺伝子にコードされるプロテインキナーゼである[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118046 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003068 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase”. Nature Genetics 18 (1): 38–43. (January 1998). doi:10.1038/ng0198-38. PMID 9425897.
- ^ “Regulation of LKB1 expression by sex hormones in adipocytes”. International Journal of Obesity 36 (7): 982–5. (July 2012). doi:10.1038/ijo.2011.172. PMID 21876548.
- ^ “LKB1 expression is inhibited by estradiol-17β in MCF-7 cells”. The Journal of Steroid Biochemistry and Molecular Biology 127 (3–5): 439–43. (November 2011). doi:10.1016/j.jsbmb.2011.06.005. PMID 21689749.
- ^ a b “Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways”. PLOS ONE 8 (2): e56567. (2013-02-22). doi:10.1371/journal.pone.0056567. PMC 3579833. PMID 23451056.
- ^ “Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss”. Oncotarget 5 (24): 12738–52. (December 2014). doi:10.18632/oncotarget.2818. PMC 4350354. PMID 25436981.
- ^ “LKB1 catalytically deficient mutants enhance cyclin D1 expression”. Cancer Research 67 (12): 5622–7. (June 2007). doi:10.1158/0008-5472.CAN-07-0762. PMID 17575127.
- ^ “Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis”. Nature Genetics 15 (1): 87–90. (January 1997). doi:10.1038/ng0197-87. PMID 8988175.
- ^ “A serine/threonine kinase gene defective in Peutz-Jeghers syndrome”. Nature 391 (6663): 184–7. (January 1998). Bibcode: 1998Natur.391..184H. doi:10.1038/34432. PMID 9428765.
- ^ “Gene symbol: STK11. Disease: Peutz-Jeghers Syndrome”. Human Genetics 124 (3): 300. (October 2008). doi:10.1007/s00439-008-0551-3. PMID 18846624.
- ^ “Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung”. Cancer Research 62 (13): 3659–62. (July 2002). PMID 12097271.
- ^ “A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome”. Oncogene 26 (57): 7825–32. (December 2007). doi:10.1038/sj.onc.1210594. PMID 17599048.
- ^ “Distribution of somatic mutations in STK11”. Catalogue of Somatic Mutations in Cancer. Wellcome Trust Genome Campus, Hinxton, Cambridge. 2009年11月11日閲覧。
- ^ “Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization”. Cancer Biology & Therapy 6 (10): 1627–31. (October 2007). doi:10.4161/cbt.6.10.4787. PMID 17921699.
- ^ PDB: 2WTK; “Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation”. Science 326 (5960): 1707–11. (December 2009). Bibcode: 2009Sci...326.1707Z. doi:10.1126/science.1178377. PMC 3518268. PMID 19892943.
- ^ a b “Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability”. The Biochemical Journal 370 (Pt 3): 849–57. (March 2003). doi:10.1042/BJ20021813. PMC 1223241. PMID 12489981.
- ^ “Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase”. PLOS ONE 9 (2): e89604. (February 2014). Bibcode: 2014PLoSO...989604Y. doi:10.1371/journal.pone.0089604. PMC 3934923. PMID 24586906.
- ^ “Analysis of the LKB1-STRAD-MO25 complex”. Journal of Cell Science 117 (Pt 26): 6365–75. (December 2004). doi:10.1242/jcs.01571. PMID 15561763.
- ^ “Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD”. The EMBO Journal 22 (12): 3062–72. (June 2003). doi:10.1093/emboj/cdg292. PMC 162144. PMID 12805220.
- ^ “LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest”. The Journal of Biological Chemistry 276 (35): 32415–8. (August 2001). doi:10.1074/jbc.C100207200. PMID 11445556.
- ^ “LKB1 catalytic activity contributes to estrogen receptor alpha signaling”. Molecular Biology of the Cell 20 (11): 2785–95. (June 2009). doi:10.1091/mbc.e08-11-1138. PMC 2688557. PMID 19369417.
[続きの解説]
L.K.B. 1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/06/17 10:10 UTC 版)
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