CD163
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/12/03 02:39 UTC 版)
CD163（cluster of differentiation 163）は、ヒトではCD163遺伝子にコードされるタンパク質である[5]。CD163は、ヘモグロビン-ハプトグロビン複合体に対する高親和性のスカベンジャー受容体であり[6]、ハプトグロビンが存在しない場合にはヘモグロビン単体に対しても低い親和性を有する[7]。また、CD163は単球/マクロファージ系統のマーカーである[8]。CD163は、グラム陽性菌・陰性菌に対する自然免疫系のセンサーとして機能する[9][10]。CD163は1987年に発見された[11]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000177575 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008845 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Entrez Gene: CD163 CD163 molecule”. 2023年12月2日閲覧。
- ^ “Identification of the haemoglobin scavenger receptor” (英語). Nature 409 (6817): 198–201. (January 2001). Bibcode: 2001Natur.409..198K. doi:10.1038/35051594. PMID 11196644.
- ^ “CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin”. Blood 107 (1): 373–80. (January 2006). doi:10.1182/blood-2005-03-1014. PMID 16189277.
- ^ “CD163: a specific marker of macrophages in paraffin-embedded tissue samples”. American Journal of Clinical Pathology 122 (5): 794–801. (November 2004). doi:10.1309/QHD6YFN81KQXUUH6. PMID 15491976.
- ^ “The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria”. Blood 113 (4): 887–92. (January 2009). doi:10.1182/blood-2008-07-167064. PMID 18849484.
- ^ “Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy”. Molecular Immunology 47 (7–8): 1650–60. (April 2010). doi:10.1016/j.molimm.2010.02.008. PMID 20299103.
- ^ “Scavenger receptor CD163 and its biological functions”. Acta Medica 52 (2): 57–61. (2009). PMID 19777868.
- ^ a b “The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage”. Journal of Neurochemistry 121 (5): 785–92. (June 2012). doi:10.1111/j.1471-4159.2012.07716.x. PMC 3412209. PMID 22380637.
- ^ “Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family”. Biochemical and Biophysical Research Communications 256 (1): 110–3. (March 1999). doi:10.1006/bbrc.1999.0294. PMID 10066432.
- ^ “Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163”. Journal of Leukocyte Biology 88 (6): 1201–5. (December 2010). doi:10.1189/jlb.0410235. PMID 20807704.
- ^ Tornai, Tamas; Vitalis, Zsuzsanna; Sipeki, Nora; Dinya, Tamas; Tornai, David; Antal‐Szalmas, Peter; Karanyi, Zsolt; Tornai, Istvan et al. (2016). “Macrophage activation marker, soluble CD163, is an independent predictor of short-term mortality in patients with cirrhosis and bacterial infection” (英語). Liver International 36 (11): 1628–1638. doi:10.1111/liv.13133. hdl:2437/223046. ISSN 1478-3231. PMID 27031405.
- ^ “Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma”. Clinical Cancer Research 19 (3): 731–42. (February 2013). doi:10.1158/1078-0432.CCR-12-2693. PMID 23224400.
- ^ “Soluble CD163”. Scandinavian Journal of Clinical and Laboratory Investigation 72 (1): 1–13. (February 2012). doi:10.3109/00365513.2011.626868. PMID 22060747.
- ^ “Hemoglobin-induced neuronal degeneration in the hippocampnus after neonatal intraventricular hemorrhage.”. Brain Research 1635: 86–94. (15 March 2016). doi:10.1016/j.brainres.2015.12.060. PMC 4801173. PMID 26772987.
- ^ “CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons.”. Translational Stroke Research 8 (6): 612–616. (April 6, 2017). doi:10.1007/s12975-017-0535-5. PMID 28386733.
- ^ “CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage.”. Stroke 48 (5): 1369–1375. (May 1, 2017). doi:10.1161/STROKEAHA.117.016850. PMC 5404936. PMID 28360115.
- ^ O'Reilly, Vincent (September 2016). “Urinary Soluble CD163 in Active Renal Vasculitis”. J Am Soc Nephrol 27 (9): 2906–2916. doi:10.1681/ASN.2015050511. PMC 5004645. PMID 26940094.
- ^ “Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages”. The Journal of Biological Chemistry 289 (2): 778–88. (January 2014). doi:10.1074/jbc.m113.520213. PMC 3887204. PMID 24275664.
- ^ “Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption”. Antioxidants & Redox Signaling 18 (17): 2254–63. (June 2013). doi:10.1089/ars.2012.4605. PMID 22793784.
- ^ “Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function”. PLOS Pathogens 13 (2): e1006206. (February 2017). doi:10.1371/journal.ppat.1006206. PMC 5322883. PMID 28231264.
- ^ “Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C”. European Journal of Immunology 31 (4): 999–1009. (April 2001). doi:10.1002/1521-4141(200104)31:4<999::AID-IMMU999>3.0.CO;2-R. PMID 11298324.
[続きの解説]
「CD163」の続きの解説一覧
- 1 CD163とは
- 2 CD163の概要
- 3 動物研究
- 4 外部リンク
- CD163のページへのリンク
