アカデシン
(AICAR から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2018/09/27 13:04 UTC 版)
アカデシン(Acadesine、国際一般名)、5-アミノイミダゾール-4-カルボキシアミド-1-β-D-リボフラノシド(5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside)、AICA-リボシド(AICA-riboside)またはAICARは、AMP活性化プロテインキナーゼのアクチベーターであり[1]、急性リンパ性白血病の治療に用いられている[2]。また糖尿病等の他の病気の治療への活用も期待されている[3]。
- ^ Favero, Carlita B.; Mandell, James W. (2007). “A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation”. Brain Research 1168: 1-10. doi:10.1016/j.brainres.2007.06.087. PMC 2000700. PMID 17706943.
- ^ Cronstein, BN; Kamen, BA (2007). “5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls?”. Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 29 (12): 805-7. doi:10.1097/MPH.0b013e31815bbb83. PMID 18090925.
- ^ Cuthbertson, Daniel J.; Babraj, John A.; Mustard, Kirsteen J.W.; Towler, Mhairi C.; Green, Kevin A.; Wackerhage, Henning; Leese, Graeme P.; Baar, Keith et al. (2007). “5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men”. Diabetes 56 (8): 2078–2084. doi:10.2337/db06-1716. ISSN 0012-1797.
- ^ http://www.reuters.com/article/pressRelease/idUS115105+11-May-2009+PRN20090511[リンク切れ]
- ^ http://www.sec.gov/Archives/edgar/data/310158/000095012310074336/y83714e10vq.htm#002
- ^ Ferris, James P.; Devadas, Balekadru; Huang, Chun Hsien; Ren, Wu Yen (1985). “Nucleosides from carbohydrate adducts of diaminomaleonitrile. A novel synthesis of 5-amino-1-(.beta.-D-ribofuranosyl)imidazole-4-carboxamide and 5-amino-1-(.beta.-D-ribopyranosyl)imidazole-4-carboxamide”. The Journal of Organic Chemistry 50 (6): 747. doi:10.1021/jo00206a004.
- ^ Corton JM, Gillespie JG, Hawley SA, Hardie DG (April 1995). “5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?”. Eur. J. Biochem. 229 (2): 558-65. doi:10.1111/j.1432-1033.1995.0558k.x. PMID 7744080.
- ^ Kim JE, Kim YW, Lee IK, Kim JY, Kang YJ, Park SY (March 2008). “AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression”. J. Pharmacol. Sci. 106 (3): 394-403. doi:10.1254/jphs.FP0071857. PMID 18360094.
- ^ Lemieux K, Konrad D, Klip A, Marette A (September 2003). “The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle”. FASEB J. 17 (12): 1658-65. doi:10.1096/fj.02-1125com. PMID 12958172.
- ^ Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM (August 2008). “AMPK and PPARδ agonists are exercise mimetics”. Cell 134 (3): 405-15. doi:10.1016/j.cell.2008.06.051. PMC 2706130. PMID 18674809.
- ^ WADA 2009 Prohibited List Archived 2009年2月3日, at the Wayback Machine.
- ^ Benkimoun, P. (2009). “Police find range of drugs after trawling bins used by Tour de France cyclists”. BMJ 339 (oct13 3): b4201–b4201. doi:10.1136/bmj.b4201. ISSN 0959-8138.
[続きの解説]
「アカデシン」の続きの解説一覧
- 1 アカデシンとは
- 2 アカデシンの概要
- AICARのページへのリンク
