プロテアーゼ活性化受容体3 機能

ウィキペディア

プロテアーゼ活性化受容体3

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/09/05 14:15 UTC 版)

機能

PAR3はGタンパク質と共役した7回膜貫通受容体ファミリーに属する。また、プロテアーゼ活性化受容体ファミリーのメンバーでもあり、トロンビンによって活性化される。PAR3は細胞外のN末端領域のタンパク質分解切断によって活性化され、新たに形成されたN末端がテザードリガンドとして受容体を活性化する。PAR3はトロンビンによるPAR4の切断と活性化のコファクターとしても機能する。

関連文献

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• “PAR3 is a cofactor for PAR4 activation by thrombin”. Nature 404 (6778): 609–13. (2000). Bibcode: 2000Natur.404..609N. doi:10.1038/35007085. PMID 10766244. 
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• “The pattern of expression of protease-activated receptors (PARs) during early trophoblast development”. J. Pathol. 200 (1): 47–52. (2003). doi:10.1002/path.1338. PMID 12692840. 
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• “Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1)”. Life Sci. 73 (3): 301–10. (2003). doi:10.1016/S0024-3205(03)00269-8. PMID 12757837. 

関連項目

• プロテアーゼ活性化受容体