補助抑制因子とは - わかりやすく解説 Weblio辞書

コリプレッサー

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/09/27 16:40 UTC 版)

分子生物学においてコリプレッサー（英: corepressor）は、遺伝子の発現を抑制する分子である^[1]。原核生物ではコリプレッサーは低分子であるが、真核生物ではコリプレッサーはタンパク質である。コリプレッサーはDNAに直接結合しないが、リプレッサーに結合することで間接的に遺伝子発現を調節する。

出典

^ Privalsky, Martin L., ed (2001) (英語). Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression. Current Topics in Microbiology and Immunology. 254. Berlin, Heidelberg: Springer Berlin Heidelberg. doi:10.1007/978-3-662-10595-5. ISBN 978-3-642-08709-7
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^ Microbiology: An Evolving Science (Second ed.). New York: W. W. Norton & Company. (2010). ISBN 978-0-393-93447-2
^ Jenster G (August 1998). “Coactivators and corepressors as mediators of nuclear receptor function: an update”. Mol. Cell. Endocrinol. 143 (1–2): 1–7. doi:10.1016/S0303-7207(98)00145-2. PMID 9806345.
^ Lazar MA (2003). “Nuclear receptor corepressors”. Nucl Recept Signal 1: e001. doi:10.1621/nrs.01001. PMC 1402229. PMID 16604174.
^ “Corepressors: custom tailoring and alterations while you wait”. Nucl Recept Signal 3 (Oct 21): e003. (2005). doi:10.1621/nrs.03003. PMC 1402215. PMID 16604171.
^ “TcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins”. Nucleic Acids Res. 39 (Database issue): D106–10. (January 2011). doi:10.1093/nar/gkq945. PMC 3013796. PMID 20965969.
^ ^a ^b ^c ^d ^e Bolander, Franklyn F. (2004), “Hormonally Regulated Transcription Factors” (英語), Molecular Endocrinology (Elsevier): pp. 387–443, doi:10.1016/b978-012111232-5/50013-0, ISBN 978-0-12-111232-5 2020年10月25日閲覧。
^ Chinnadurai, G (February 2002). “CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis” (英語). Molecular Cell 9 (2): 213–224. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595.
^ ^a ^b ^c Kammer, Gary M. (2004), “Estrogen, Signal Transduction, and Systemic Lupus Erythematosus: Molecular Mechanisms” (英語), Principles of Gender-Specific Medicine (Elsevier): pp. 1082–1092, doi:10.1016/b978-012440905-7/50375-3, ISBN 978-0-12-440905-7 2020年10月25日閲覧。
^ Kadamb, Rama; Mittal, Shilpi; Bansal, Nidhi; Batra, Harish; Saluja, Daman (August 2013). “Sin3: Insight into its transcription regulatory functions” (英語). European Journal of Cell Biology 92 (8–9): 237–246. doi:10.1016/j.ejcb.2013.09.001. PMID 24189169.
^ ^a ^b Rosenfeld, M. G. (2006-06-01). “Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response” (英語). Genes & Development 20 (11): 1405–1428. doi:10.1101/gad.1424806. ISSN 0890-9369. PMID 16751179.
^ ^a ^b ^c ^d Battaglia, Sebastiano; Maguire, Orla; Campbell, Moray J. (2010). “Transcription factor co-repressors in cancer biology: roles and targeting” (英語). International Journal of Cancer 126 (11): 2511–9. doi:10.1002/ijc.25181. PMC 2847647. PMID 20091860.
^ ^a ^b Christian, Mark; White, Roger; Parker, Malcolm G. (August 2006). “Metabolic regulation by the nuclear receptor corepressor RIP140” (英語). Trends in Endocrinology & Metabolism 17 (6): 243–250. doi:10.1016/j.tem.2006.06.008. PMID 16815031.
^ ^a ^b ^c Ogawa, S.; Lozach, J.; Jepsen, K.; Sawka-Verhelle, D.; Perissi, V.; Sasik, R.; Rose, D. W.; Johnson, R. S. et al. (2004-10-05). “A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation” (英語). Proceedings of the National Academy of Sciences 101 (40): 14461–14466. Bibcode: 2004PNAS..10114461O. doi:10.1073/pnas.0405786101. ISSN 0027-8424. PMC 521940. PMID 15452344.
^ Jepsen, Kristen; Hermanson, Ola; Onami, Thandi M; Gleiberman, Anatoli S; Lunyak, Victoria; McEvilly, Robert J; Kurokawa, Riki; Kumar, Vivek et al. (September 2000). “Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development” (英語). Cell 102 (6): 753–763. doi:10.1016/S0092-8674(00)00064-7. PMID 11030619.
^ Privalsky, Martin L. (March 2004). “The Role of Corepressors in Transcriptional Regulation by Nuclear Hormone Receptors”. Annual Review of Physiology 66 (1): 315–360. doi:10.1146/annurev.physiol.66.032802.155556. ISSN 0066-4278. PMID 14977406.
^ ^a ^b ^c ^d Tiacci, E.; Grossmann, V.; Martelli, M. P.; Kohlmann, A.; Haferlach, T.; Falini, B. (2011-12-30). “The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia”. Haematologica 97 (1): 3–5. doi:10.3324/haematol.2011.057901. ISSN 0390-6078. PMC 3248923. PMID 22210327.
^ ^a ^b ^c Grossmann, Vera; Tiacci, Enrico; Holmes, Antony B.; Kohlmann, Alexander; Martelli, Maria Paola; Kern, Wolfgang; Spanhol-Rosseto, Ariele; Klein, Hans-Ulrich et al. (2011-12-01). “Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype”. Blood 118 (23): 6153–6163. doi:10.1182/blood-2011-07-365320. ISSN 0006-4971. PMID 22012066.
^ ^a ^b Li, Meng; Collins, Roxane; Jiao, Yuchen; Ouillette, Peter; Bixby, Dale; Erba, Harry; Vogelstein, Bert; Kinzler, Kenneth W. et al. (2011-11-24). “Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia”. Blood 118 (22): 5914–5917. doi:10.1182/blood-2011-05-356204. ISSN 0006-4971. PMC 3228503. PMID 21989985.
^ Pagan, Julia K.; Arnold, Jeremy; Hanchard, Kim J.; Kumar, Raman; Bruno, Tiziana; Jones, Mathew J. K.; Richard, Derek J.; Forrest, Alistair et al. (2007-03-22). “A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP”. Journal of Biological Chemistry 282 (20): 15248–15257. doi:10.1074/jbc.m700246200. ISSN 0021-9258. PMID 17379597.
^ Vaiopoulos, Aristeidis G.; Kostakis, Ioannis D.; Athanasoula, Kalliopi Ch.; Papavassiliou, Athanasios G. (June 2012). “Targeting transcription factor corepressors in tumor cells” (英語). Cellular and Molecular Life Sciences 69 (11): 1745–1753. doi:10.1007/s00018-012-0986-5. ISSN 1420-682X. PMID 22527719.
^ ^a ^b ^c Cerchietti, Leandro C.; Ghetu, Alexandru F.; Zhu, Xiao; Da Silva, Gustavo F.; Zhong, Shijun; Matthews, Marilyn; Bunting, Karen L.; Polo, Jose M. et al. (April 2010). “A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo” (英語). Cancer Cell 17 (4): 400–411. doi:10.1016/j.ccr.2009.12.050. PMC 2858395. PMID 20385364.
^ ^a ^b ^c Cerchietti, Leandro C.; Yang, Shao Ning; Shaknovich, Rita; Hatzi, Katerina; Polo, Jose M.; Chadburn, Amy; Dowdy, Steven F.; Melnick, Ari (2009-04-09). “A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo” (英語). Blood 113 (15): 3397–3405. doi:10.1182/blood-2008-07-168773. ISSN 0006-4971. PMC 2668844. PMID 18927431.
^ Parekh, Samir; Privé, Gilbert; Melnick, Ari (January 2008). “Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas” (英語). Leukemia & Lymphoma 49 (5): 874–882. doi:10.1080/10428190801895345. ISSN 1042-8194. PMC 2748726. PMID 18452090.
^ ^a ^b Yasui, Takeshi; Yamamoto, Takeshi; Sakai, Nozomu; Asano, Kouhei; Takai, Takafumi; Yoshitomi, Yayoi; Davis, Melinda; Takagi, Terufumi et al. (September 2017). “Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design” (英語). Bioorganic & Medicinal Chemistry 25 (17): 4876–4886. doi:10.1016/j.bmc.2017.07.037. PMID 28760529.
^ Sena, Paola; Mariani, Francesco; Benincasa, Marta; De Leon, Maurizio Ponz; Di Gregorio, Carmela; Mancini, Stefano; Cavani, Francesco; Smargiassi, Alberto et al. (January 2014). “Morphological and quantitative analysis of BCL6 expression in human colorectal carcinogenesis” (英語). Oncology Reports 31 (1): 103–110. doi:10.3892/or.2013.2846. ISSN 1021-335X. PMID 24220798.
^ Sun, Naihui; Zhang, Liang; Zhang, Chongguang; Yuan, Yuan (December 2020). “miR-144-3p inhibits cell proliferation of colorectal cancer cells by targeting BCL6 via inhibition of Wnt/β-catenin signaling” (英語). Cellular & Molecular Biology Letters 25 (1): 19. doi:10.1186/s11658-020-00210-3. ISSN 1425-8153. PMC 7079415. PMID 32206063.
^ Deb, Dhruba; Rajaram, Satwik; Larsen, Jill E.; Dospoy, Patrick D.; Marullo, Rossella; Li, Long Shan; Avila, Kimberley; Xue, Fengtian et al. (2017-06-01). “Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non–Small Cell Lung Cancers” (英語). Cancer Research 77 (11): 3070–3081. doi:10.1158/0008-5472.CAN-15-3052. ISSN 0008-5472. PMC 5489259. PMID 28377453.
^ Sun, Chengcao; Li, Shujun; Yang, Cuili; Xi, Yongyong; Wang, Liang; Zhang, Feng; Li, Dejia (February 2016). “MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6” (英語). Biochemical and Biophysical Research Communications 471 (1): 82–88. doi:10.1016/j.bbrc.2016.01.175. PMID 26845350.
^ Venteclef, N.; Jakobsson, T.; Ehrlund, A.; Damdimopoulos, A.; Mikkonen, L.; Ellis, E.; Nilsson, L.-M.; Parini, P. et al. (2010-02-15). “GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR in the hepatic acute phase response” (英語). Genes & Development 24 (4): 381–395. doi:10.1101/gad.545110. ISSN 0890-9369. PMC 2816737. PMID 20159957.
^ Yoon, Chong-Hyeon; Kwon, Yong-Jin; Lee, Sang-Won; Park, Yong-Beom; Lee, Soo-Kon; Park, Min-Chan (January 2013). “Activation of Liver X Receptors Suppresses Inflammatory Gene Expressions and Transcriptional Corepressor Clearance in Rheumatoid Arthritis Fibroblast Like Synoviocytes” (英語). Journal of Clinical Immunology 33 (1): 190–199. doi:10.1007/s10875-012-9799-4. ISSN 0271-9142. PMID 22990668.
^ ^a ^b Lee, Eun-Jung; Kwon, Jeong-Eun; Park, Min-Jung; Jung, Kyung-Ah; Kim, Da-Som; Kim, Eun-Kyung; Lee, Seung Hoon; Choi, Jong Young et al. (August 2017). “Ursodeoxycholic acid attenuates experimental autoimmune arthritis by targeting Th17 and inducing pAMPK and transcriptional corepressor SMILE” (英語). Immunology Letters 188: 1–8. doi:10.1016/j.imlet.2017.05.011. PMID 28539269.
^ Sarkar, Sujata; Fox, David A. (May 2010). “Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis” (英語). Rheumatic Disease Clinics of North America 36 (2): 345–366. doi:10.1016/j.rdc.2010.02.006. PMID 20510238.

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