唾液検査
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/01/01 04:27 UTC 版)
唾液検査または唾液学は、内分泌や免疫、炎症、感染などの状態を示すマーカーを特定するため、研究室において唾液の分析を行う検査手法である。唾液は、コルチゾールなどのステロイドホルモンや、遺伝物質であるRNA、酵素や抗体などのタンパク質、また、一酸化窒素の状態(「心血管疾患」の「一酸化窒素：心筋保護の唾液中バイオマーカー」項も参照)を示すバイオマーカーである唾液中亜硝酸塩や、天然代謝物など、様々な物質の分析に有用な体液である。 唾液検査はクッシング病や無排卵、HIV、癌、寄生虫、性腺機能低下症、アレルギーを含む多くの病気や病状の検査・診断に利用される。また、アメリカ合衆国政府により行われる宇宙飛行士の概日リズムの変化の測定や、軍のサバイバル訓練中の兵士に対するホルモン動態の検査にも唾液検査が使用されている[1][2]。
- ^ “Hormone profiles in humans experiencing military survival training”. Biol. Psychiatry 47 (10): 891–901. (May 2000). doi:10.1016/s0006-3223(99)00307-8. PMID 10807962.
- ^ “Melatonin and cortisol assessment of circadian shifts in astronauts before flight”. J. Pineal Res. 18 (3): 141–7. (April 1995). doi:10.1111/j.1600-079x.1995.tb00152.x. PMID 7562371.
- ^ Granger Douglas A., Kivlighan Katie T., Fortunato Christine, Harmon Amanda G., Hibel Leah C., Schwartz Eve B., Whembolua Guy-Lucien (2007). “Integration of Salivary Biomarkers into Developmental and Behaviorally-oriented Research: Problems and Solutions for Collecting Specimens”. Physiology & Behavior 92 (4): 583–90. doi:10.1016/j.physbeh.2007.05.004. PMID 17572453.
- ^ Johnson, M.D., James; Johnson, Esq., Henry James, eds (1836). The Medico-chirurgical Review and Journal of Practical Medicine. 24. Richard & George S. Wood. p. 231; 233.
- ^ Nicholson, William (1808). A Dictionary of Practical and Theoretical Chemistry: With Its Application to the Arts and Manufactures, and to the Explanation of the Phaenomena of Nature... : with Plates and Tables. Richard Phillips. p. 2 R 2
- ^ Nicolas de Blégny (1685). Zodiacus Medico-Gallicus, sive miscellaneorum curiosorum, medico-physicorum sylloge. 5. Chouët. p. 149
- ^ a b c d e Wong DT (March 2006). “Salivary diagnostics powered by nanotechnologies, proteomics and genomics”. J Am Dent Assoc 137 (3): 313–21. doi:10.14219/jada.archive.2006.0180. PMID 16570464.
- ^ Shirtcliff Elizabeth A., Granger Douglas A., Schwartz Eve, Curran Mary J. (2001). “Use of Salivary Biomarkers in Biobehavioral Research: Cotton-based Sample Collection Methods Can Interfere with Salivary Immunoassay Results”. Psychoneuroendocrinology 26 (2): 165–73. doi:10.1016/s0306-4530(00)00042-1. PMID 11087962.
- ^ “Salimetrics Salivary Research”. 2015年12月29日閲覧。
- ^ a b Takai, Noriyasu; Yamaguchi, M.; Aragaki, T.; Eto, K.; Uchihashi, K.; Nishikawa, Y. (2004). “Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults”. Archives of Oral Biology 49 (12): 963–968. doi:10.1016/j.archoralbio.2004.06.007. PMID 15485637.
- ^ a b Groschl, Michael (November 2008). “Current status of salivary hormone analysis”. Clinical Chemistry 54 (11): 1759–1769. doi:10.1373/clinchem.2008.108910. PMID 18757583.
- ^ Westenberg, P. M.; Bokhorst, C. L.; Miers, A. C.; Sumter, S. R.; Kallen, V. L.; van Pelt, J.; Blöte, A. W. (October 2009). “A prepared speech in front of a pre-recorded audience: subjective, physiological, and neuroendocrine responses to the Leiden Public Speaking Task”. Biological Psychology 82 (2): 116–124. doi:10.1016/j.biopsycho.2009.06.005. PMID 19576261.
- ^ Granger, Douglas A., L. A. Serbin, A. Schwartzman, P. Lehoux, and J. Cooperman. "Children's Salivary Cortisol, Internalizing Behaviour Problems, and Family Environment: Results from the Concordia Longitudinal Risk Project." Int. J. Behav. Dev. 22 (1998): 707-28. Web.
- ^ Rohleder, Nicolas; Nater, U. M.; Wolf, J. M.; Ehlert, U.; Kirschbaum, C. (December 2004). “Psychosocial stress-induced activation of salivary alpha amylase: an indicator of sympathetic activity?”. Annals of the New York Academy of Sciences 1032 (1): 258–263. Bibcode: 2004NYASA1032..258R. doi:10.1196/annals.1314.033. PMID 15677423.
- ^ Granger Douglas A., Kivlighan Kate T. (2006). “Salivary α-amylase Response to Competition: Relation to Gender, Previous Experience, and Attitudes”. Psychoneuroendocrinology 31 (6): 703–14. doi:10.1016/j.psyneuen.2006.01.007. PMID 16624493.
- ^ Nicolson, Nancy A. (2008). L.J. Luecken and L.C. Gallo. ed. Measurement of Cortisol. In: Handbook of Psychological Research Methods in Health Psychology. Sage Publications. pp. 37–74
- ^ a b Klimes-Dougan B., Hastings P., Granger D., Barbara U., Zahn-Waxler C. (2001). “Adrenocortical activity in at-risk and normally developing adolescents: Individual differences in salivary cortisol basal levels, diunal variation, and responses to social challenges”. Development and Psychopathology 13 (3): 695–719. doi:10.1017/s0954579401003157. PMID 11523855.
- ^ a b c d e f g h i j k l m Kudielka, B., Hellhammer, D. H., & Wust, S. (2009, January). Why do we respond so differently? reviewing determinants of human salivary cortisol responses to challenge.
- ^ “The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline”. J. Clin. Endocrinol. Metab. 93 (5): 1526–40. (May 2008). doi:10.1210/jc.2008-0125. PMC 2386281. PMID 18334580.
- ^ Raff H (October 2009). “Utility of salivary cortisol measurements in Cushing's syndrome and adrenal insufficiency”. J. Clin. Endocrinol. Metab. 94 (10): 3647–55. doi:10.1210/jc.2009-1166. PMID 19602555.
- ^ “Evaluation of plasma, salivary, and urinary cortisol levels for diagnosis of Cushing's syndrome”. Endocr. J. 57 (4): 331–7. (2010). doi:10.1507/endocrj.k09e-340. PMID 20139634.
- ^ “Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders”. Clin. Biochem. 41 (9): 688–92. (June 2008). doi:10.1016/j.clinbiochem.2008.01.015. PMID 18280810.
- ^ “Utility of salivary melatonin measurements in the assessment of the pineal physiology in newborn infants”. Clin. Biochem. 43 (10–11): 868–72. (July 2010). doi:10.1016/j.clinbiochem.2010.04.059. PMID 20433823.
- ^ “Measuring melatonin in humans”. J Clin Sleep Med 4 (1): 66–9. (February 2008). doi:10.5664/jcsm.27083. PMC 2276833. PMID 18350967.
- ^ “Salivary sex hormone measurement in a national, population-based study of older adults”. J Gerontol B Psychol Sci Soc Sci 64 Suppl 1: i94–105. (November 2009). doi:10.1093/geronb/gbn028. PMC 2763516. PMID 19204073.
- ^ Boothby LA, Doering PL (August 2008). “Bioidentical hormone therapy: a panacea that lacks supportive evidence”. Curr. Opin. Obstet. Gynecol. 20 (4): 400–7. doi:10.1097/GCO.0b013e3283081ae9. PMID 18660693.
- ^ McBane, SE (2008). “Easing vasomotor symptoms: Besides HRT, what works?”. Journal of the American Academy of Physicians Assistants 21 (4): 26–31. doi:10.1097/01720610-200804000-00012. PMID 18468366.
- ^ Fugh-Berman, A; Bythrow J (2007). “Bioidentical hormones for menopausal hormone therapy: variation on a theme”. Journal of General Internal Medicine 22 (7): 1030–4. doi:10.1007/s11606-007-0141-4. PMC 2219716. PMID 17549577.
- ^ “Biochemical evaluation in human saliva with special reference to ovulation detection”. Indian J Dent Res 21 (2): 165–8. (2010). doi:10.4103/0970-9290.66625. PMID 20657081.
- ^ “Salivary steroid assays for assessing variation in endocrine activity”. J. Steroid Biochem. 19 (1A): 265–72. (July 1983). doi:10.1016/S0022-4731(83)80035-1. PMID 6887863.
- ^ “Saliva as a medium for investigating intra- and interindividual differences in sex hormone levels in premenopausal women”. Cancer Epidemiol. Biomarkers Prev. 10 (1): 59–64. (January 2001). PMID 11205490.
- ^ Voss HF (January 1999). “Saliva as a fluid for measurement of estriol levels”. Am. J. Obstet. Gynecol. 180 (1 Pt 3): S226–31. doi:10.1016/s0002-9378(99)70706-4. PMID 9914623.
- ^ “Free testosterone, luteinizing hormone/follicle stimulating hormone ratio and pelvic sonography in relation to skin manifestations in patients with polycystic ovary syndrome”. Saudi Med J 28 (7): 1039–43. (July 2007). PMID 17603706.
- ^ “Measurements of salivary progesterone throughout the menstrual cycle in women suffering from unexplained infertility reveal high frequency of luteal phase defects”. Fertil. Steril. 54 (2): 211–6. (August 1990). doi:10.1016/s0015-0282(16)53691-7. PMID 2116329.
- ^ “Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS: Method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism”. J. Chromatogr. B 877 (25): 2615–23. (September 2009). doi:10.1016/j.jchromb.2008.10.051. PMID 19010090.
- ^ “Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism”. Clin. Endocrinol. 67 (5): 656–62. (November 2007). doi:10.1111/j.1365-2265.2007.02937.x. PMID 17953627.
- ^ “Validation of salivary testosterone as a screening test for male hypogonadism”. Aging Male 9 (3): 165–9. (September 2006). doi:10.1080/13685530600907993. PMID 17050116.
- ^ “Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer”. Gastroenterology 138 (3): 949–57.e1–7. (March 2010). doi:10.1053/j.gastro.2009.11.010. PMC 2831159. PMID 19931263.
- ^ “Biomarkers of pancreatic cancer”. Pancreatology 11 Suppl 2 (2): 14–9. (2011). doi:10.1159/000323479. PMID 21464582.
- ^ “Altered biochemical parameters in the saliva of patients with breast cancer”. Tohoku J. Exp. Med. 214 (2): 89–96. (February 2008). doi:10.1620/tjem.214.89. PMID 18285665.
- ^ “The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study”. Clin. Cancer Res. 6 (6): 2363–70. (June 2000). PMID 10873088.
- ^ “A preliminary study of CA15-3, c-erbB-2, epidermal growth factor receptor, cathepsin-D, and p53 in saliva among women with breast carcinoma”. Cancer Invest. 18 (2): 101–9. (2000). doi:10.3109/07357900009038240. PMID 10705871.
- ^ “Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer”. Anal. Chim. Acta 681 (1–2): 41–8. (November 2010). doi:10.1016/j.aca.2010.09.030. PMID 21035601.
- ^ “Salivary analysis of oral cancer biomarkers”. Br. J. Cancer 101 (7): 1194–8. (October 2009). doi:10.1038/sj.bjc.6605290. PMC 2768098. PMID 19789535.
- ^ a b “Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection”. Clin. Cancer Res. 15 (17): 5473–7. (September 2009). doi:10.1158/1078-0432.CCR-09-0736. PMC 2752355. PMID 19706812.
- ^ “Serum circulating human mRNA profiling and its utility for oral cancer detection”. J. Clin. Oncol. 24 (11): 1754–60. (April 2006). doi:10.1200/JCO.2005.03.7598. PMID 16505414.
- ^ “Salivary glucose concentration and excretion in normal and diabetic subjects”. J. Biomed. Biotechnol. 2009: 430426. (2009). doi:10.1155/2009/430426. PMC 2686806. PMID 19503844.
- ^ “Spectroscopic characterization of the inclusion complex of a luteinizing hormone-releasing hormone agonist, buserelin acetate, with dimethyl-beta-cyclodextrin”. Chem. Pharm. Bull. 45 (2): 378–83. (February 1997). doi:10.1248/cpb.45.378. PMID 9118452.
- ^ “Chromogranin A detection in saliva of type 2 diabetes patients”. Bosn J Basic Med Sci 10 (1): 2–8. (February 2010). doi:10.17305/bjbms.2010.2725. PMC 5596606. PMID 20192923.
- ^ “Association of salivary lysozyme and C-reactive protein with metabolic syndrome”. J. Clin. Periodontol. 37 (9): 805–11. (September 2010). doi:10.1111/j.1600-051X.2010.01605.x. PMC 2923268. PMID 20666873.
- ^ “An evaluation of the performance of OraQuick ADVANCE Rapid HIV-1/2 Test in a high-risk population attending genitourinary medicine clinics in East London, UK”. Int J STD AIDS 19 (10): 665–7. (October 2008). doi:10.1258/ijsa.2008.008132. PMID 18824617.
- ^ “Field evaluation of diagnostic accuracy of an oral fluid rapid test for HIV, tested at point-of-service sites in rural Zimbabwe”. AIDS Patient Care STDs 23 (7): 571–6. (July 2009). doi:10.1089/apc.2008.0225. PMC 2856437. PMID 19530953.
- ^ U.S. Food & Drug Administration. Vaccines, Blood & Biologics. Complete List of Donor Screening Assays for Infectious Agents and HIV Diagnostic Assays. https://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/BloodDonorScreening/InfectiousDisease/ucm080466.htm
- ^ “Evaluation of saliva specimens as an alternative sampling method to detect hepatitis B surface antigen”. J. Clin. Lab. Anal. 25 (2): 134–41. (2011). doi:10.1002/jcla.20447. PMC 6647618. PMID 21438008.
- ^ “Importance of the cutoff ratio for detecting antibodies against hepatitis A virus in oral fluids by enzyme immunoassay”. J. Virol. Methods 173 (2): 169–74. (May 2011). doi:10.1016/j.jviromet.2011.01.014. PMID 21295610.
- ^ “Comparison between serum and saliva for the detection of hepatitis A virus RNA”. J. Virol. Methods 148 (1–2): 74–80. (March 2008). doi:10.1016/j.jviromet.2007.10.020. PMID 18160140.
- ^ “Detection of HCV salivary antibodies by a simple and rapid test”. J. Virol. Methods 133 (1): 1–5. (April 2006). doi:10.1016/j.jviromet.2005.09.009. PMID 16360219.
- ^ “Diagnosis of amebic liver abscess and amebic colitis by detection of Entamoeba histolytica DNA in blood, urine, and saliva by a real-time PCR assay”. J. Clin. Microbiol. 48 (8): 2798–801. (August 2010). doi:10.1128/JCM.00152-10. PMC 2916621. PMID 20534800.
- ^ “Detection of IgA anti-Entamoeba histolytica in the patients' saliva”. J Egypt Soc Parasitol 34 (3 Suppl): 1095–104. (December 2004). PMID 15658064.
- ^ “Diagnosis of intestinal amebiasis using salivary IgA antibody detection”. J. Infect. Dis. 162 (6): 1360–4. (December 1990). doi:10.1093/infdis/162.6.1360. PMID 2230266.
- ^ “Performance of a Western immunoblot assay to detect specific anti-Toxoplasma gondii IgG antibodies in human saliva”. J. Parasitol. 91 (3): 561–3. (June 2005). doi:10.1645/GE-423R. PMID 16108547.
- ^ Acosta E (1990). “Antibodies to the metacestode of Taenia solium in the saliva from patients with neurocysticercosis”. J. Clin. Lab. Anal. 4 (2): 90–4. doi:10.1002/jcla.1860040204. PMID 2313474.
- ^ “Detection and evaluation of salivary antibodies to Helicobacter pylori in dyspeptic patients”. Int. J. Clin. Pract. 59 (4): 433–6. (April 2005). doi:10.1111/j.1368-5031.2005.00495.x. PMID 15853860.
- ^ “Rapid diagnosis of Helicobacter pylori infection in dyspeptic patients using salivary secretion: a non-invasive approach”. Singapore Med J 46 (5): 224–8. (May 2005). PMID 15858691.
- ^ “Changes in saliva protein composition in patients with periodontal disease”. Acta Odontol Latinoam 22 (2): 105–12. (2009). PMID 19839486.
- ^ “Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis”. J. Clin. Periodontol. 37 (6): 487–93. (June 2010). doi:10.1111/j.1600-051X.2010.01563.x. PMID 20507371.
- ^ a b “One-step homogeneous C-reactive protein assay for saliva”. J. Immunol. Methods 373 (1–2): 19–25. (October 2011). doi:10.1016/j.jim.2011.07.013. PMID 21821037.
- ^ “Novel aspects of dietary nitrate and human health”. Annu Rev Nutr 33: 129–59. (2013). doi:10.1146/annurev-nutr-071812-161159. PMID 23642194.
- ^ Hezel M; Weitzberg E (2013) The oral microbiome and nitric oxide homoeostasis. Oral Dis. Jun 28. doi: 10.1111/odi.12157. [Epub ahead of print]
- ^ Lundberg JO, Weitzberg E, Cole JA, Benjamin N. Nitrate, bacteria and human health (2004) Nat Rev Microbiol. 2:593-602. Erratum in: Nat Rev Microbiol. 2:681.
- ^ “Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans”. J Appl Physiol 107 (4): 1144–55. (2009). doi:10.1152/japplphysiol.00722.2009. PMID 19661447.
- ^ “Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits”. Eur J Nutr 50 (5): 293–303. (2011). doi:10.1007/s00394-011-0192-5. PMC 3489477. PMID 21626413.
- ^ http://berkeleytest.com/plant-based.html
- ^ “Effects of dietary nitrate on blood pressure in healthy volunteers”. N Engl J Med 355 (26): 2792–3. (2006). doi:10.1056/nejmc062800. PMID 17192551.
- ^ a b “Turning DASH Strategy into Reality for Improved Cardio Wellness Outcomes: Part II” (2013年7月25日). 2021年12月31日閲覧。
- ^ “Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers”. Nitric Oxide 22 (2): 136–40. (2010). doi:10.1016/j.niox.2009.10.007. PMID 19887114.
- ^ “Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite”. Hypertension 51 (3): 784–90. (2008). doi:10.1161/HYPERTENSIONAHA.107.103523. PMC 2839282. PMID 18250365.
- ^ Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ, Ahluwalia A (2010) Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO" Hypertension 56(2):274-81. doi: 10.1161/HYPERTENSIONAHA.110.153536. Erratum in: Hypertension. 2010 Sep;56(3):e37-9.
- ^ “Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential”. Hypertension 61 (5): 1091–102. (2013). doi:10.1161/HYPERTENSIONAHA.111.00933. PMID 23589565.
- ^ “Physiological role for nitrate-reducing oral bacteria in blood pressure control”. Free Radic Biol Med 55: 93–100. (2013). doi:10.1016/j.freeradbiomed.2012.11.013. PMC 3605573. PMID 23183324.
- ^ “Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age”. Clin. Exp. Allergy 32 (9): 1293–8. (September 2002). doi:10.1046/j.1365-2222.2002.01470.x. PMID 12220466.
- ^ “A search for biomarkers as diagnostic tools for food allergy: a pilot study in peanut-allergic patients”. Int. Arch. Allergy Immunol. 155 (1): 23–30. (2011). doi:10.1159/000318654. PMID 21109745.
- ^ “Saliva secretory IgA antibodies against molds and mycotoxins in patients exposed to toxigenic fungi”. Immunopharmacol Immunotoxicol 25 (4): 595–614. (November 2003). doi:10.1081/IPH-120026444. PMID 14686801.
- ^ a b “Saliva as a diagnostic medium”. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 153 (2): 103–10. (June 2009). doi:10.5507/bp.2009.017. PMID 19771133.
- ^ “Simple diagnostic tests to detect toxic alcohol intoxications”. Transl Res 152 (4): 194–201. (October 2008). doi:10.1016/j.trsl.2008.07.002. PMC 2615242. PMID 18940722.
- ^ “Saliva as an alternative specimen for alcohol determination in the human body”. Pol J Pharmacol 54 (2): 161–5. (2002). PMID 12139114.
- ^ J Anal Toxicol. 2011 Jan;35(1):32-9. Oral fluid is a viable alternative for monitoring drug abuse: detection of drugs in oral fluid by liquid chromatography-tandem mass spectrometry and comparison to the results from urine samples from patients treated with Methadone or Buprenorphine. Vindenes V, Yttredal B, Oiestad EL, Waal H, Bernard JP, Mørland JG, Christophersen AS. Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, P.O. 4404, Nydalen, 0403 Oslo, Norway.
- ^ “Salivary sex hormones during the menstrual cycle”. Endocr. J. 56 (3): 521–3. (2009). doi:10.1507/endocrj.k09e-020. PMID 19194049.
- ^ Greenspan’s Basic & Clinical Endocrinology, 8th Ed. Saliva Testing directly measures active steroid hormone levels. 2007.
- ^ J Clin Endocrinol Metab. 2010 Dec;95(12):5141-3. Standardization of hormonal assays for the 21st century. Wartofsky L, Handelsman DJ.
- ^ “Current developments in salivary diagnostics”. Biomark Med 4 (1): 171–89. (February 2010). doi:10.2217/bmm.09.68. PMC 2857781. PMID 20387312.
[続きの解説]
唾液検査と同じ種類の言葉
- 唾液検査のページへのリンク
