CD4 CD4の概要

CD4
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT, 2KLU, 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6, 2QAD, 3B71, 3CD4, 3JWD, 3JWO, 3LQA, 3O2D, 3S5L, 3T0E, 4JM2, 1WBR, 3S4S, 4H8W, 4P9H, 4Q6I, 4R2G, 4R4H, 4RQS, 3J70, 5A7X, 5A8H, 5CAY
識別子
記号	CD4, CD4mut, CD4 molecule, OKT4D, IMD79
外部ID	OMIM: 186940 MGI: 88335 HomoloGene: 513 GeneCards: CD4
遺伝子の位置 (ヒト)
染色体	12番染色体 (ヒト)
終点	6,820,799 bp
遺伝子の位置 (マウス)
染色体	6番染色体 (マウス)
終点	124,865,184 bp
遺伝子オントロジー
分子機能	• 膜貫通シグナル伝達受容体活性; • virus receptor activity; • protein homodimerization activity; • zinc ion binding; • extracellular matrix structural constituent; • 酵素結合; • immunoglobulin binding; • 血漿タンパク結合; • coreceptor activity; • interleukin-16 binding; • interleukin-16 receptor activity; • MHC class II protein binding; • identical protein binding; • protein tyrosine kinase binding; • シグナル伝達受容体活性; • プロテインキナーゼ結合; • 受容体結合;
細胞の構成要素	• endoplasmic reticulum lumen; • integral component of membrane; • early endosome; • 膜; • cell surface; • endoplasmic reticulum membrane; • 脂質ラフト; • T cell receptor complex; • external side of plasma membrane; • 細胞膜; • clathrin-coated vesicle membrane; • integral component of plasma membrane;
生物学的プロセス	• transmembrane receptor protein tyrosine kinase signaling pathway; • defense response to Gram-negative bacterium; • positive regulation of protein kinase activity; • mitigation of host defenses by virus; • positive regulation of calcium-mediated signaling; • シグナル伝達; • helper T cell enhancement of adaptive immune response; • T cell selection; • エストラジオールへの反応; • induction by virus of host cell-cell fusion; • adaptive immune response; • response to vitamin D; • T cell differentiation; • 細胞表面受容体シグナル伝達経路; • positive regulation of T cell proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • enzyme linked receptor protein signaling pathway; • T cell activation; • positive regulation of T cell activation; • maintenance of protein location in cell; • サイトカイン産生; • T cell receptor signaling pathway; • 免疫系プロセス; • positive regulation of calcium ion transport into cytosol; • regulation of T cell activation; • 免疫応答; • 細胞接着; • viral process; • fusion of virus membrane with host plasma membrane; • membrane organization; • positive regulation of protein phosphorylation; • positive regulation of kinase activity; • interleukin-15-mediated signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of MAPK cascade; • positive regulation of monocyte differentiation; • positive regulation of transcription, DNA-templated; • positive regulation of viral entry into host cell; • regulation of calcium ion transport; • positive regulation of ERK1 and ERK2 cascade; • cellular response to granulocyte macrophage colony-stimulating factor stimulus; • サイトカイン媒介シグナル伝達経路; • macrophage differentiation;
	出典:Amigo / QuickGO
オルソログ
	920
	12504
	ENSG00000010610
	ENSMUSG00000023274
	P01730
	P06332
NM_000616; NM_001195014; NM_001195015; NM_001195016; NM_001195017;
	NM_001382705; NM_001382706; NM_001382707; NM_001382714
	NM_013488
NP_000607; NP_001181943; NP_001181944; NP_001181945; NP_001181946;
	NP_001369634; NP_001369635; NP_001369636; NP_001369643
	NP_038516
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

CD4陽性T細胞はヒトの免疫系において必要不可欠な白血球である。しばしばCD4細胞、Th細胞、T4細胞と呼ばれることもある（以下CD4細胞）。この細胞の主要な役割はCD8陽性T細胞（いわゆるキラーT細胞、もしくは細胞傷害性T細胞、以下CD8細胞）などの他の免疫系細胞にシグナルを送ることであり、このことからCD4細胞はヘルパー細胞と呼ばれる。CD4細胞がシグナルを送ると、CD8細胞はそれを受けて感染細胞を破壊しこれを殺す。無治療のHIV-1感染患者や臓器移植前の免疫抑制状態のようにCD4細胞が枯渇すると、健常者では発現しない感染症の病原体に感染し易くなる（日和見感染）。

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010610 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023274 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Alain Bernard (1984) (英語). Leucocyte typing: human leucocyte differentiation antigens detected by monoclonal antibodies: specification, classification, nomenclature: [report on the first international references workshop sponsored by INSERM, WHO and IUIS]. Berlin: Springer. pp. pages 45–48. ISBN 0-387-12056-4
^ Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM (June 1986). “The gene encoding the T-cell surface protein T4 is located on human chromosome 12”. Proc. Natl. Acad. Sci. U.S.A. 83 (12): 4399–402. doi:10.1073/pnas.83.12.4399. PMC 323740. PMID 3086883.
^ Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (April 1996). “A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13”. Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.
^ Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA (June 1998). “Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody”. Nature 393 (6686): 648–59. doi:10.1038/31405. PMID 9641677.
^ Bofill M, Janossy G, Lee CA, MacDonald-Burns D, Phillips AN, Sabin C, Timms A, Johnson MA, Kernoff PB (May 1992). “Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis”. Clin. Exp. Immunol. 88 (2): 243–52. PMC 1554313. PMID 1349272.
^ Kumarasen Cooper; Anthony S-Y. Leong (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 65. ISBN 1-84110-100-1
^ Zamani M, Tabatabaiefar MA, Mosayyebi S, Mashaghi A, Mansouri P (July 2010). “Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population”. Clin. Exp. Dermatol. 35 (5): 521–4. doi:10.1111/j.1365-2230.2009.03667.x. PMID 19843086.

[前の解説]

[続きの解説]

「CD4」の続きの解説一覧

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000010610 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023274 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[isbn0-387-12056-4-5] Alain Bernard (1984) (英語). Leucocyte typing: human leucocyte differentiation antigens detected by monoclonal antibodies: specification, classification, nomenclature: [report on the first international references workshop sponsored by INSERM, WHO and IUIS]. Berlin: Springer. pp. pages 45–48. ISBN 0-387-12056-4

[pmid3086883-6] Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM (June 1986). “The gene encoding the T-cell surface protein T4 is located on human chromosome 12”. Proc. Natl. Acad. Sci. U.S.A. 83 (12): 4399–402. doi:10.1073/pnas.83.12.4399. PMC 323740. PMID 3086883.

[pmid8723724-7] Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (April 1996). “A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13”. Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.

[pmid9641677-8] Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA (June 1998). “Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody”. Nature 393 (6686): 648–59. doi:10.1038/31405. PMID 9641677.

[pmid1349272-9] Bofill M, Janossy G, Lee CA, MacDonald-Burns D, Phillips AN, Sabin C, Timms A, Johnson MA, Kernoff PB (May 1992). “Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis”. Clin. Exp. Immunol. 88 (2): 243–52. PMC 1554313. PMID 1349272.

[isbn1-84110-100-1-10] Kumarasen Cooper; Anthony S-Y. Leong (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 65. ISBN 1-84110-100-1

[pmid19843086-11] Zamani M, Tabatabaiefar MA, Mosayyebi S, Mashaghi A, Mansouri P (July 2010). “Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population”. Clin. Exp. Dermatol. 35 (5): 521–4. doi:10.1111/j.1365-2230.2009.03667.x. PMID 19843086.

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CD4 CD4の概要

CD4

急上昇のことば

「CD4」の関連用語