ULK1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/05/06 23:52 UTC 版)
ULK1（unc-51 like autophagy activating kinase 1）は、ヒトではULK1遺伝子によってコードされる酵素である[5][6]。オートファジーに関与するキナーゼであり、特にアミノ酸の除去に対して応答する。ヒトにはULK1とともにULK2と呼ばれるホモログが存在する。両者の比較研究は多くは行われていないが、いくつかの差異が存在することが記載されている[7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000177169 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029512 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment”. Genomics 51 (1): 76–85. (July 1998). doi:10.1006/geno.1998.5340. PMID 9693035.
- ^ “Entrez Gene: ULK1 unc-51-like kinase 1 (C. elegans)”. 2022年2月20日閲覧。
- ^ “Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes”. Autophagy 9 (12): 2103–14. (December 2013). doi:10.4161/auto.26563. PMC 4028344. PMID 24135897.
- ^ a b c d “Structure and function of the ULK1 complex in autophagy”. Current Opinion in Cell Biology 39: 61–8. (April 2016). doi:10.1016/j.ceb.2016.02.010. PMC 4828305. PMID 26921696.
- ^ a b “Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors”. ACS Chemical Biology 10 (1): 257–61. (January 2015). doi:10.1021/cb500835z. PMC 4301081. PMID 25551253.
- ^ “ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase”. Nature Cell Biology 15 (7): 741–50. (July 2013). doi:10.1038/ncb2757. PMC 3885611. PMID 23685627.
- ^ “AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1”. Nature Cell Biology 13 (2): 132–41. (February 2011). doi:10.1038/ncb2152. PMC 3987946. PMID 21258367.
- ^ “Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates”. PLoS Genetics 11 (2): e1004987. (2015). doi:10.1371/journal.pgen.1004987. PMC 4344198. PMID 25723488.
- ^ a b Okazaki, N.; Yan, J.; Yuasa, S.; Ueno, T.; Kominami, E.; Masuho, Y.; Koga, H.; Muramatsu, M. (2000-12-28). “Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation”. Brain Research. Molecular Brain Research 85 (1-2): 1–12. doi:10.1016/s0169-328x(00)00218-7. ISSN 0169-328X. PMID 11146101.
- ^ Ewing, Rob M.; Chu, Peter; Elisma, Fred; Li, Hongyan; Taylor, Paul; Climie, Shane; McBroom-Cerajewski, Linda; Robinson, Mark D. et al. (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology 3: 89. doi:10.1038/msb4100134. ISSN 1744-4292. PMC 1847948. PMID 17353931.
- ^ a b Tomoda, Toshifumi; Kim, Jee Hae; Zhan, Caixin; Hatten, Mary E. (2004-03-01). “Role of Unc51.1 and its binding partners in CNS axon outgrowth”. Genes & Development 18 (5): 541–558. doi:10.1101/gad.1151204. ISSN 0890-9369. PMC 374236. PMID 15014045.
- ^ “AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1”. Nature Cell Biology 13 (2): 132–41. (February 2011). doi:10.1038/ncb2152. PMC 3987946. PMID 21258367.
- ^ “Posttranslational modification of autophagy-related proteins in macroautophagy”. Autophagy 11 (1): 28–45. (2015-01-02). doi:10.4161/15548627.2014.984267. PMC 4502723. PMID 25484070.
- ^ “Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes”. Scientific Reports 10 (1): 19068. (November 2020). doi:10.1038/s41598-020-76227-7. PMC 7642411. PMID 33149253.
- ^ “Ulk1 over-expression in human gastric cancer is correlated with patients' T classification and cancer relapse”. Oncotarget 8 (20): 33704–33712. (May 2017). doi:10.18632/oncotarget.16734. PMC 5464904. PMID 28410240.
- ^ “Neuronal autophagy and neurodevelopmental disorders”. Experimental Neurobiology 22 (3): 133–42. (September 2013). doi:10.5607/en.2013.22.3.133. PMC 3807000. PMID 24167408.
- ^ “Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease”. Inflammatory Bowel Diseases 17 (6): 1392–7. (June 2011). doi:10.1002/ibd.21486. PMID 21560199.
- ^ “Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates”. Molecular Cell 59 (2): 285–97. (July 2015). doi:10.1016/j.molcel.2015.05.031. PMC 4530630. PMID 26118643.
[続きの解説]
- ULK1のページへのリンク
