ヘッジホッグシグナル伝達経路
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/02/22 09:34 UTC 版)
ヘッジホッグシグナル伝達経路（- でんたつけいろ、英：Hedgehog signaling pathway）は、ヘッジホッグタンパク質を中心としたシグナル伝達経路である。 発生している胚では頭側・尾側、右側・左側などの位置が決定されそれに基づいてそれぞれ異なった発生過程をたどり、 またいくつかの分節を形成しそれぞれが異なった形に発達する。胚が正常に発生できるようにおのおのの細胞は「ヘッジホッグシグナル伝達経路」に基づいてこのような正しい位置情報を獲得する。すなわち、胚では場所に応じて異なった濃度のヘッジホッグシグナルを構成するタンパク質が見られるのである。 発生過程のみならず成体においてもこのシグナル伝達経路は働いている。 ここに異常が生じると、基底細胞癌のような疾患を発症する[1]。
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- ^ 臨床試験番号 NCT00636610 研究名 "A Study of GDC-0449 (Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer" - ClinicalTrials.gov
- ^ 臨床試験番号 NCT00607724 研究名 "GDC-0449 in Treating Patients With Locally Advanced or Metastatic Solid Tumors" - ClinicalTrials.gov
[続きの解説]
「ヘッジホッグシグナル伝達経路」の続きの解説一覧
- 1 ヘッジホッグシグナル伝達経路とは
- 2 ヘッジホッグシグナル伝達経路の概要
- 3 ショウジョウバエ
- 4 脊椎動物
- 5 関連項目
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